An injectable device, comprising a hyaluronic acid-based composition, useful for long lasting facial sculpting and correction of facial features, for example, for augmenting and shaping the profile, including for example, the chin, jawline or the nose, in a human being is provided. Methods of treatment are also provided.

Methods of treating chin retrusion in a subject by increasing a glabella-subnasale-pogonion (G-Sn-Pog) facial angle of the subject are provided, which may include injecting a first volume of a dermal filler into a pogonion, injecting a second volume of a dermal filler into a mentum, and/or injecting a third volume of the dermal filler into a left pre-jowl sulcus and/or a right pre-jowl sulcus, wherein the G-Sn-Pog facial angle of the subject is increased by at least about 1° or more. Methods of treating chin retrusion are provided that may include injecting a first volume of a dermal filler into a pogonion, injecting a second volume of a dermal filler into a mentum, and/or injecting a third volume of the dermal filler into a left pre-jowl sulcus and/or a right pre jowl sulcus, wherein the chin retrusion of the subject is decreased by at least about 2 mm.

An injection system includes an injection system body defining a proximal opening at a proximal end thereof and a distal needle interface at a distal end thereof. The system also includes proximal and distal stopper members disposed in the injection system body, forming a proximal drug chamber between the proximal and distal stopper members and a distal drug chamber between the distal stopper member and the distal end of the injection system body. The system further includes a plunger member configured to be manually manipulated to insert the proximal stopper member relative to the injection system body. Moreover, the system includes a valve forming an openable barrier between the distal needle interface and at least a portion of the distal drug chamber. The valve is configured to allow flow from the portion of the distal drug chamber to the distal needle interface with increased pressure in the distal drug chamber.

The present invention provides novel medical devices for use in surgical procedures and methods for manufacturing novel medical devices. In some embodiments, the novel medical devices can include surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the surgical needles can be manufactured with one or more coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Novel methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided.

Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

An implantation needle for inserting a subcutaneously insertable element into a body tissue, a kit for inserting a subcutaneously insertable element into a body tissue and a method of manufacturing an implantation needle are described. The implantation needle comprises at least one covering comprising at least one pharmaceutical compound. The pharmaceutical compound is configured to remain at least partially in the body tissue after insertion of the subcutaneously insertable element.

A hybrid blunt cannula with puncture needle assembly that includes a barrel body having a sidewall, two opposing ends, defining and enclosing a barrel channel, and defining a button translation channel through the sidewall of the barrel body, a hub translatably disposed within the barrel channel, an outer cannula member with one end disposed within the hub and a second end for contacting an individual's skin, defining an eye thereon, an inner needle member of a substantially rigid material disposed within the outer cannula member and having a second inner needle free end that is of a sharp configuration, and having a button translatably coupled to the hub, disposed within the button translation channel, and operably configured to modulate the hub and outer cannular member independent of the inner needle member to cause the inner needle to translate through the second cannular end to puncture the individual's skin.

Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).

A facemask includes integrated actuating modules having sensors and other mechanisms. The facemask has one or more sockets into which various modules may be inserted. The facemask itself or the modules may include air filters and check valves to regulate airflow along or through the various modules. The modules may detect various substances either in the ambient air or the air exhaled by the wearer. The facemask also includes modules for measuring pulmonary and/or cardiovascular exertion, lung capacity and other physiological metrics. Other modules may provide supplements, vitamins or other substances such as tobacco smoke or vapor from vaporizers to the wearer. The modules may include microcontrollers in wireless communication with software applications on electronic devices so that the facemask may also serve as a cellular phone.

Some embodiments are directed to a needle assembly including at least N injection needles where N is at least four and a multiple of two. The needle assembly also includes a first liquid port adapted to be connected to an injection device, and N second liquid ports connected to one of the N injection needles. N/2 main liquid pathways each have an entrance connected to the first liquid port and an exit, further including N/2 secondary liquid pathways that have two extremities each opening on one of the N second liquid ports, and a mid portion connected to the exit of one of the main liquid pathways. The main liquid pathways and the secondary liquid pathways define N liquid flow paths between the first liquid port and the N second liquid ports dimensioned so a pressure drop between them is similar.