An intravenous (IV) device assembly may include a catheter adapter and a needle guard residing within a bore of the catheter adapter. The needle guard may include a needle formed through a guard bore. The guard bore may include a first internal diameter along a first bore portion and a second internal diameter, smaller than the first bore portion, along a second bore portion. A clip may be coupled to the exterior surface of the needle guard. The clip may include a first arm, which may include a first end guard, and a second arm, which may include a second end guard. The clip may be slidable distally along the exterior surface of the needle guard to move from an open configuration to a closed configuration, thereby blocking distal motion of the needle within the needle guard.

The present invention provides a delivery device for administration of active agent (12) containing compositions into the suprachoroidal space or supraciliary space. The invention provides methods of treatment of an ocular disease or condition accordingly. The invention also provides active agent containing compositions for delivery into the suprachoroidal space or supraciliary space.

The invention relates to a needle delivery device comprising a device body; one or more skin pinching members attached to the device body, the skin pinching members being moveable to pinch a longitudinal fold of skin of a patient. The device also comprises e a drive mechanism configured to drive a needle out of the device body and along a needle path into the longitudinal fold of skin pinched between the pinching members, and subsequently withdraw the needle, the needle path extending substantially parallel to the surface of the patient.

A medical device may include a needle, including a plurality of links and a distal tip, reciprocally movable between a first configuration and a second configuration, and a conduit including a lumen extending through the needle, the conduit being coupled to the distal tip, wherein longitudinal movement of the conduit is configured to transition the needle between the first configuration and the second configuration.

A medical instrument having an aspiration and/or injection needle and handle device. The handle device provides audible and/or tactile feedback during the application of activation forces, thus enabling the user to determine where the distal end of the aspiration and/or injection needle is relative to a sheath. More than two grooves are present on a shaft of an activation handle of the handle device. An O-ring resides within a handle portion of the handle device. The O-ring seats and unseats within the grooves based on the amount of applied force.

An intravenous catheter assembly configured to provide two-stage visual indication during catheter insertion into a vein of a patient. The catheter insertion assembly including an insertion needle and a catheter coaxially positioned over the insertion needle to define an annular space between a radial wall of the insertion needle in a flexible wall of the catheter divided into a first axial chamber and a second axial chamber by a formed region of the flexible wall having a diameter configured to inhibit flow between the first axial chamber and the second axial chamber, thereby enabling blood to flow into the first axial chamber when the insertion needle and catheter are in an initial position, and enabling blood to flow into the second axial chamber when the insertion needle and catheter translate axially relative to one another.

The purpose of the present invention is to provide an injection needle and an injection device which are capable of adjusting the puncture depth of a needle. The present invention is equipped with: a needle; a needle base holding the needle such that the needle protrudes from the distal end side; and an adjuster provided on the outer periphery of the needle base so as to be movable in the axial direction of the needle base. By adjusting the axial-direction position of the adjuster, the protrusion length of the needle can be adjusted. Consequently, the puncture depth of the needle can be adjusted, and there is no need to prepare a plurality of type of injection needles having different protrusion lengths.

A device for local administration of pharmaceutical fluids. The device has at least one capillary with at least one opening in the region of its distal end, a hollow intermediate piece which is connected with the at least one capillary so as to allow the passage of liquid, a guide for directing the intermediate piece which comprises a distal support for resting on the patient, and a fixing element for fixing the intermediate piece to the guide. The fixing element allows fixing of the intermediate piece in various positions relative to the guide. Such fixation prevents displacement of the intermediate piece in relation to the guide. Also disclosed is a method for preparing such a device.

Blockchain environments may mix-and-match different encryption, difficulty, and/or proof-of-work schemes when mining blockchain transactions. Each encryption, difficulty, and/or proof-of-work scheme may be separate, stand-alone programs, files, or third-party services. Blockchain miners may be agnostic to a particular coin's or network's encryption, difficulty, and/or proof-of-work schemes, thus allowing any blockchain miner to process or mine data in multiple blockchains. GPUs, ASICs, and other specialized processing hardware components may be deterred by forcing cache misses, cache latencies, and processor stalls. Hashing, difficulty, and/or proof-of-work schemes require less programming code, consume less storage space/usage in bytes, and execute faster. Blockchain mining schemes may further randomize byte or memory block access, further improve cryptographic security.

A biologic composition responsive to inflammation has an allograft scaffold matrix for injection or implantation. The allograft scaffold matrix has donor quiescent and/or senescent cells. The donor quiescent and/or senescent cells react in response to signaling of inflammation from host cells or matrix. The reaction to signaling causes the donor quiescent and/or senescent cells to secrete anti-inflammatory cytokines and secrete exosomes to initiate regeneration of the area of the inflammation. The biologic composition further has a cryoprotectant. The cryoprotectant is a polyampholyte, preferably the polyampholyte is an ε-poly-L-lysine. The cryoprotectant is not DMSO or glycerol based. The cryoprotectant is suitable for direct implantation without washing from the allograft scaffold matrix in either a diluted or non-diluted state.