The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of the resulting mixture from the device. The mixing device comprises a syringe having an open end and outlet and containing a first component; and a cap with a fixed outer body and an expandable chamber contained therein, wherein said cap is removably attached to the outlet of the syringe and a cross-section of the cap is larger than a syringe cross-section and the cap is shorter than the syringe.

The invention inter alia relates to a dispense interface for an ejection device. The dispense interface comprises at least two inlets, at least one outlet, a body part, and a fluid channel arrangement within the body part configured to provide fluid communication between the at least two inlets and the at least one outlet; wherein each of the at least two inlets is formed from a tubelike fluid element; wherein each of the tubelike fluid elements is molded into the body part; and wherein each of the tubelike fluid elements provides at least a part of the fluid channel arrangement within said body part.

The invention relates to syringes for storing and mixing components.

A method for preparing a pre-filled multi-chamber injection system includes providing an injection system body, the injection system body defining an open proximal end, a body interior, and an open distal end. The method also includes introducing a first substance into a distal end of the body interior. The method further includes disposing a distal stopper member in the body interior, the distal stopper member and the injection system body defining proximal and distal chambers in the body interior. Moreover, the method includes introducing a second substance into the body interior. In addition, the method includes disposing a proximal stopper member in the body interior. The method also includes inserting an elongate member at least partially into the body interior, the elongate member having a plurality of flow channels for fluidly coupling the proximal and distal chambers. The method further includes coupling a plunger member to the proximal stopper member.

An injection device which includes a housing (12), a needle hub (38) slidable within the housing (12), a needle (40) having a distal end piercing tip (42) and a proximal end piercing tip (44), the needle hub (40) being moveable from a first position wherein the distal piercing tip (42) is within the housing to a second position wherein the distal end piercing tip (42) extends outwardly of housing (12), a first spring (23) biasing the needle hub (38) towards the first position, and a cartridge receiving member (48) mounted within the housing, and a plunger rod assembly (166), the plunger rod assembly (166) having a distal interior chamber (102) and a proximal interior chamber (103), the distal interior chamber (102) being designed to receive a cartridge (85) containing a liquid (89), the cartridge having a septum (87) and a plunger (88) to prevent exit of the liquid, and a second needle hub (91) located in the proximal chamber, a second hollow needle (92) mounted in the second needle hub, the second hollow needle having a distal piercing tip (94) and a proximal piercing tip (93), the second hollow needle being moveable from a first non piercing position to a second position whereby said distal piercing tip (94) will pierce the septum (87).

The invention inter alia relates to a dispense interface for an ejection device. The dispense interface comprises at least two inlets, at least one outlet, a body part, and a fluid channel arrangement within the body part configured to provide fluid communication between the at least two inlets and the at least one outlet; wherein each of the at least two inlets is formed from a tubelike fluid element; wherein each of the tubelike fluid elements is molded into the body part; and wherein each of the tubelike fluid elements provides at least a part of the fluid channel arrangement within said body part.

The invention is related to a dispense interface for a drug delivery device for delivering at least two drug agents, wherein the dispense interface is configured to be coupled to a cartridge holder of the drug delivery device, wherein the cartridge holder is configured to hold at least two cartridges, wherein the dispense interface comprises at least two inlet channels, each comprising a fluid inlet opening, wherein each fluid inlet opening is configured to receive fluid from a respective cartridge of the at least two cartridges when the dispense interface is axially coupled to the cartridge holder, an outlet channel comprising a fluid outlet opening, a valve structure configured to be selectively moved into any one of a plurality of positions, wherein in at least one position the valve structure selectively permits or prevents fluid flow from any of the at least two inlet channels to the outlet channel. The invention is further related to a drug delivery device for delivering at least two drug agents comprising a dispense interface of the aforementioned kind.

The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.

A portable dual chamber auto-injector configured to store a dry opioid antagonist medicament separately from a liquid component, wherein a user actuated mixing system comprising a movable component to create a fluidic pathway between the first and second chambers and release a portion of energy from a pre-stored energy to drive a displacement mechanism into the first chamber and displace the liquid component into the second chamber and solubilize the opioid antagonist. A needle assembly in fluid communication with the second chamber can be used to transfer the solubilized opioid antagonist.

An injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (7) containing a primary reservoir (11) containing a first medicament (1) and having a secondary reservoir (5, 17, 30) containing a second medicament (2) where the drug delivery device (7) has only one dose setter (12) for the primary reservoir (11) and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface (3, 16, 21, 31).