A rectal injection device and a method of operating a rectal injection device. In one embodiment, the device includes: (1) a handle having a trigger associated therewith, (2) an extension tube extending from the handle and terminating in a head, (3) at least two needles coupled to the head and configured to move relative thereto between a retracted position and a deployed position and (4) a pullrod coupling the trigger and the needles and configured to cause the needles to move.

The present invention concerns an injection device for delivering a substance to the skin of a subject. The injection device is suitable for precise and even distribution of the substance to the skin and minimizing waste of injectable substance. The injection device comprises multiple cannulas, is connectable to standard syringes and particularly useful in dermatological treatments.

Methods of actuating a needle array device can include causing fluid to move through flow channels to needle apertures that are spaced apart from an inflow aperture at different distances where flow channels that have approximately equal pathway lengths and where the fluid can reach tips of the needle apertures approximately simultaneously, which can provide an approximately equal dosage or fluid volume through the tips of the needle apertures.

A needle structure for injecting a filler and monitoring a blood backflow situation simultaneously includes a needle, a housing and a partitioning member. The needle includes a needle chamber and a needle opening connected to the needle chamber. The housing includes a housing chamber and a housing opening connected to the housing chamber, and the housing chamber is connected to the needle chamber to form a needle housing chamber. The partitioning member is disposed in the needle housing chamber. The needle housing chamber is separated into a first chamber and a second chamber by the partitioning member. The needle opening is separated into an injection opening and a blood backflow opening by the partitioning member. The first chamber is connected to the injection opening, and the blood backflow opening and the housing opening are connected by the second chamber.

A tissue penetrating system has a housing member, a plurality of penetrating members positioned in the housing member and a plurality of sample chambers. Each sample chamber is associated with a penetrating member. A tissue stabilizing member has a tissue interface surface configured to be applied to a tissue surface and provide for spontaneous flow of blood for sample capture. The tissue stabilizing member is coupled to the housing.

A pen needle assembly apparatus (60) includes a housing (30), a movable support (40) for supporting a pen needle (18), an ejector (80) for ejecting a used pen needle from the support, and an actuator (56). The support (40) is rotated relative to the housing (30) to index the pen needles to a position where the pen needle can be accessed and coupled to a delivery device (10). The used pen needle (18) is returned to the well (42) in the support and the support rotated toward the ejector (80) where the used pen needle is ejected to a compartment (50) in the housing for disposal. A cover (60) on the housing includes at least one opening (65) for accessing the pen needle when the support is rotated to position a pen needle relative to the opening in the cover.

Systems and methods for mitigating the formation of heterotopic ossification lesions by delivering a neuromuscular inhibitor employ a delivery device to distribute injection of the neuromuscular inhibitor. A delivery device for delivering the neuromuscular inhibitor can include an injector body, a device body for spacing the injector body from a target delivery location, and a plurality of needles; or can include an injector guide having multiple guide holes and an injector needle for delivering the neuromuscular inhibitor via the guide holes.

A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet along a path into the tissue site, and a manual switch for a user interface input.

A dispense mechanism for a drug delivery device for the delivery of a primary medicament in a primary cartridge and a secondary medicament in a secondary cartridge includes a primary drive member and a secondary drive member serve for driving a primary and a secondary lead screw. The primary drive member and the secondary drive member are configured to rotate during dose dispense. A coupling member serves for rotationally coupling the primary drive member to the secondary drive member and moves from a first position in which the primary drive member is rotationally decoupled from the secondary drive member into a second position in which the primary drive member is rotationally coupled to the secondary drive member during dose dispense. Rotation of the primary drive member moves the coupling member from the first position into the second position.

A closed-system grinding syringe (10, 110) is provided for liquefying and delivering a solid dosage form (20), including a barrel (22), a fluid port (30) disposed on a bottom wall (28) of the barrel (22), and a plunger (32). A head (36) of the plunger (32) is insertable into and moveable within the barrel (22) such that (a) a portion of the barrel (22) defines a closed-system syringe chamber (46) between the bottom barrel wall (28) and a lower surface (64) of the plunger head (36), and (b) a plunger-head annular seal (42) forms a fluid-tight seal between an outer surface (44) of the plunger head (36) and a cylindrical inner surface (26) of the barrel (22). A solid-dosage-form support disc (60, 360) is disposed below a bottom plunger wall (38) so as to define a grinding compartment (62) between the lower surface (64) of the bottom plunger wall (38) and an upper surface (66) of the solid-dosage-form support disc (60, 360), and is shaped so as to define a plurality of holes (68, 368) through the solid-dosage-form support disc (60, 360).