Described herein are syringe devices comprising a syringe including a therapeutic dose of at least one drug to be used in a drug or substance overdose. Also provided herein are compositions and methods of treating opioid overdose using high dose naloxone.

Described herein are syringe devices comprising a syringe including a therapeutic dose of at least one drug to be used in a drug or substance overdose. Also provided herein are compositions and methods of treating opioid overdose using high dose naloxone.

In a locking device for locking a plunger rod a plunger rod locking portion is provided for locking a plunger rod of a syringe after use and preventing re-use of the syringe. A chamber is formed inside the plunger rod locking portion for receiving the disc-shaped proximal end of the plunger rod after use of the syringe. The plunger rod locking portion comprises at least one positive locking device configured to positively lock the axial position of the plunger rod by positive-fit engagement with the disc-shaped proximal end of the plunger rod and retain the disc-shaped proximal end of the plunger rod inside the chamber. The locking device provides the functionality of a tamper-evident plunger rod locking device once a dose of medication has been injected by pushing the plunger rod forward, for preventing inadvertent re-use of the syringe.

A single-use syringe, comprising a barrel, and a first resilient unidirectionally-biased peripheral annulus formed inside the barrel; an upper plunger, having a dome shaped bottom mounted at a first end of the upper plunger, a first flange formed at a second end of the upper plunger with a second flange formed adjacent to it; a lower plunger having a second resilient unidirectionally-biased peripheral annulus formed near a top end of the lower plunger and a third resilient unidirectionally-biased peripheral annulus formed further inside the lower plunger, wherein a holding space is defined by a space between the second annulus and the third annulus, allowing the dome shaped bottom be inserted through the second annulus, held in the holding space, and pressed against the third annulus during a syringe unlocked state, and wherein a locking chamber is defined by a space between the third annulus and the lower plunger bottom end.

A syringe holder includes: a barrel body that holds a syringe; a holder opening; deformation promoting portions; and radial movement-restricting portions. The radial movement-restricting portions are provided close to the deformation promoting portions. Being brought into contact with first portions, the radial movement-restricting portions restrict the syringe from moving in a radial direction with respect to the barrel body.

Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.

An assembly (47) for a medication delivery device (1) has a body (2), a dose setting part (8) configured to be operated by a user for selecting a size of a dose, a piston rod (13) configured to be moved axially without rotating for dispensing a medication, and a drive member (12) being directly coupled to the piston rod (13) for driving the piston rod (13) in a dose dispensing operation, wherein the drive member (12) moves in a proximal direction in the dose setting operation. The medication delivery device (1) into which the assembly is incorporated may be a single-shot, variable-dose injection device, e.g., a syringe.

The present invention relates to a medicament delivery device comprising a housing, a biased medicament delivery member guard arranged movable in relation to the housing from a proximally extended position to a retracted position, a power pack comprising a plunger rod and a force element arranged to act on said plunger rod, which power pack is actuated by a release clip movable in relation to the housing and arranged to said plunger rod for releasably holding said plunger rod with the force element in a tensioned state; a rotator rotatably arranged inside said housing, which rotator is arranged with a guide element and a medicament delivery member guard lock element on its outer surface, wherein said medicament delivery member guard is arranged with release clip activation elements operably arranged to act on said release clip for releasing said plunger rod, and wherein said medicament delivery member guard is further arranged with a rotator activator element arranged to cooperate with said guide element for turning said rotator, upon movement of said medicament delivery member guard to the retracted position, and wherein, upon movement of said medicament delivery member guard back to the extended position, said rotator activator element will engage said medicament delivery member guard lock element and lock said medicament delivery member guard in a shielding position after removal of said medicament delivery device from a medicament delivery site.

Described herein are syringe devices comprising a syringe including a therapeutic dose of at least one drug to be used in a drug or substance overdose. Also provided herein are compositions and methods of treating opioid overdose using high dose naloxone.

A prefilled syringe includes a syringe barrel including: a liquid drug discharge portion on a distal end of the barrel, and an opening on a proximal end of the barrel; a cap; a gasket located in the syringe barrel; a plunger including: a shaft portion inserted in the syringe barrel from the opening, and a pressing portion located on a proximal end of the shaft portion and configured to be manually pushed by a user, the plunger being movable toward a distal direction by pushing the pressing portion to slide the gasket toward the liquid drug discharge portion; a liquid drug; an upraised portion located on an inner wall of the syringe barrel between the gasket and the opening; and a clicker.