A delivery device is provided having a container containing a dose of greater than 40 mg of a powder and having at least one exit orifice for dispensing the dose from the container, a chamber adapted to receive the container in an operative configuration, at least one gas inlet by which gas may enter the chamber and at least one gas outlet by which gas and entrained powder may exit the chamber. The delivery device is operable to generate a gas flow through the chamber between the at least one gas inlet and the at least one gas outlet, which brings about orbital motion of the container within the chamber in that at least a central region of the container orbits a central axis of the chamber.

An apparatus for aerosolized powder delivery includes first and second chambers containing gas at first and second pressures, respectively, above atmospheric pressure. A powder is contained within the first or second chamber. The first chamber has a first external wall and a separating wall shared with the second chamber. The first external wall or the separating wall is configured to rupture if the pressure difference across it becomes equal to or greater than a threshold pressure difference. Specifically, the apparatus is configured so that the difference between the second pressure and atmospheric pressure is greater than the threshold pressure difference. Initially, the difference between the second and first pressures is less than the pressure difference required to rupture the separating wall, and the difference between the first pressure and atmospheric pressure is less than the pressure difference required to rupture the first external wall.

A hand operable inhalator for dispensing a powdery substance, in particular a pharmaceutical substance, with a supply chamber, a discharge channel and a dosing chamber, wherein the discharge channel protrudes into the supply chamber, and the dosing chamber and discharge channel can be moved relative to each other. In order to indicate an inhalator for dispensing a powdery substance that makes the dosing chamber advantageously fillable, the discharge channel can be rotated around a rotational axis, and that the dosing chamber can be filled while the discharge channel rotates. The inhalator can have a dosing chamber that can be moved from a closed into an open state and vice versa. The inhalator can have a discharge channel that incorporates a turbulence means, which has a helically running wall and is to carry a flow while discharging air provided with the substance.

A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.

The present invention provides in part dry powder inhaler (DPI) devices for dispensing dry powder and methods for using the same. The DPI devices feature exchangeable cartridges having drum mechanisms that prepare metered doses of dry powder, and are able to direct air in a turbulent manner sufficient to entrain and deagglomerate a dose of dry powder for delivery into a user's lungs. The DPI devices feature a reservoir of dry powder advanced by a plunger, as well as a gauge that advances with the plunger to indicate the amount of dry powder remaining in the reservoir.

The multi-chambered well dosage form and device disclosed herein can be single or multi dose capable for administration of pharmaceuticals of a range of particle sizes. The present dosage devices and systems provide for improved efficiency and patient ease of use owing to its compact size and simple design, low cost, and consistent, contamination free dosing of dry powder medicaments or other agents. The present disclosure provides a multi-chambered dosage form containing dry powder medical composition containing chamber well with an internal piercing device and one or more adjacent gas-filled chamber wells to aid the dispense of the powder contents to the user and in certain embodiments, without the requirement of an external energy sources common with active devices known in the art. Said methods, systems and devices provide increased ejection fraction and hence greater efficiency of drug delivery above that as provided by current devices.

A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.

The invention provides a method of testing an inhaler based on performing an optical analysis of a dry powder medicament plume discharged from the inhaler upon actuation. More particularly, embodiments of the invention comprise illuminating the dry powder plume with a source of electromagnetic radiation and capturing one or more images of a pattern of radiation reflected or diffracted by the illuminated plume. The images are subsequently processed to determine and/or analyse one or more geometric and/or dynamic characteristics of the plume.

A nebulizer and a method of breathing using the nebulizer is described. The nebulizer and breathing techniques are capable of delivering medicament into the sinus cavity of a user.

A fluid dispenser device with a main body (10); a reservoir (21) containing a dose of powder; a reservoir opening mechanism (80); a dispenser orifice (5); a movable support mechanism (50) to displace a reservoir (21) against the opening mechanism on actuation and displaceable between a non-dispensing position and a dispensing position, urged towards the dispensing position, and held in the non-dispensing position by a blocking mechanism (100). An inhalation trigger system (60) is provided that has a deformable air chamber (61) and a trigger element (600) that co-operates firstly with the air chamber (61) and secondly with the blocking mechanism. The fluid dispenser device further includes an electronic dose counter or indicator device (300) including a sensor (306) to detect displacement or deformation of a portion of the fluid dispenser device, generated while the user is inhaling or after the user has inhaled.