The method includes defining a cavity within a housing of a vapor-generating article, the vapor-generating article having a first end, a second end and a middle section, first inserting at least one portion of a retention medium within the housing between the first end and the middle section, and second inserting a first frangible capsule to be near or at least partially within the retention medium, the first frangible capsule including a first volatile substrate.

Provided is a Dry Powder Inhaler (DPI) arrangement comprising a DPI arranged in fluid communication with a spacer device (110) comprising a bag (112) and a body (118) including inlet (114) and opposed outlet (116), the inlet (114) and opposed outlet (116) being provided on, and integral with, the body (118). The body (118) and bag (112) combine to form chamber (120) for operatively receiving vaporised dry powder medication. The inlet (114) and outlet (116) each are in the form of a port that is in fluid flow communication with the chamber (120). The inlet (114) and outlet (116) define, and are separated by, a broad V-formation formed as part of the body (118). The body (118) further includes an elliptical lower perimeter (118.1) defining flange (118.2), for demountably receiving bag (112).

A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.

A dry powder inhaler (1) has a chamber (12) for housing a capsule and an inhalation channel (22), the chamber (12) is shaped in order to determine an agitated motion of the capsule in the chamber (12) during an inhalation of a user, the inhaler (1) comprises a capsule-piercing mechanism (30) arranged to pierce a capsule in the chamber (12) and a monitoring system (40) comprising an accelerometer (42) arranged on a printed circuit board (48) in order to measure mechanical oscillations determined at least by the agitated motion and by a flow of air through the chamber (12) and/or inhalation channel (22); a detection unit (44) arranged to detect an activation of the capsule-piercing mechanism (30); and an electronic processing unit (46) configured to receive signals from the detection unit (44) and from the accelerometer (42). Reception of a signal from the detection unit (44) triggers processing of signals from the accelerometer (42) by the electronic processing unit (46) in order to generate inhalation data.

A capsule (6) contains a liquid (28) to be supplied to an atomizer (20) and is mounted on or in an electronic smoking device (1). The capsule (6) has a controller (40) including a memory, which receives data from and transmits data to control electronics (14) of the electronic smoking device (1). A capacitor in the capsule (6) is charged by the electronic smoking device (1) and powers the controller (40) during intermediate intervals. Electrical contacts (26, 48) of the capsule are connected to electrical contacts (24, 46) of the electronic smoking device (1) to charge the capacitor and exchange data.

An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.

An aerosol-generating system is provided, including an aerosol-generating article and an aerosol-generating device. The aerosol-generating article includes a first compartment having a first one of a volatile delivery enhancing compound source and a medicament source; and a second compartment having a second one of the volatile delivery enhancing compound source and the medicament source. The aerosol-generating device includes a cavity configured to receive the first compartment and the second compartment; and an external heater positioned about a perimeter of the cavity. The aerosol-generating device is configured to heat the first compartment and the second compartment so that the first compartment has a lower temperature than the second compartment.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.