Modular smoking devices that vaporize certain materials, such as tobacco or cannabis are disclosed. The technology provides for intelligent ignition, combustion, or vaporization of given material at the appropriate temperatures that prevent generation of harmful and unwanted byproducts. According to one embodiment, the modular smoking device comprises a self-contained combustion chamber to hold the material, a combustion mechanism integrated with the self-contained combustion chamber, and an energy source, such as a rechargeable battery, to power the combustion mechanism. The combustion mechanism is configured to provide targeted combustion of the material, where the active ingredients generated upon the combustion are consumed by inhaling a smoke or vapor resulting from the combustion or vaporization. The self-contained combustion chamber includes a lighterless combustion mechanism such as a piezoelectric lighter or a lighter sold under TESLA COIL LIGHTERS® that is designed to arc an electric discharge through the material in the self-contained combustion chamber.

An aerosol-generating system comprising: an aerosol-generating article (1), the aerosol-generating article comprising a single metered dose of an aerosol-forming substrate; an airflow pathway (108) arranged between an air inlet (110) and an air outlet (112); an aerosolisation chamber (116) arranged at a location along the airflow pathway (108) such that the airflow pathway passes through at least a portion of the aerosolisation chamber (116); and a flow controller (122, 124) for selectively controlling the flow of air through the airflow pathway (108), the flow controller (122, 124) having an open configuration in which air can flow into and out of the aerosolisation chamber (116) and a closed configuration in which air is substantially prevented from flowing into and out of the aerosolisation chamber (116); wherein the aerosolisation chamber (116) is configured to open to receive only one aerosol-generating article (1) at a time; wherein the aerosolisation chamber (116) is configured to close to contain the aerosol-generating article (1); the aerosol-generating system further comprising a heating element (118, 120) arranged to heat the aerosolisation chamber (116) when an aerosol-generating article (1) is received within the aerosolisation chamber (116); wherein the aerosol-generating system is configured to heat the aerosolisation chamber (116) containing the aerosol-generating article (1) only when the flow controller (122, 124) is in the closed configuration.

An aerosol provision system comprising: a substrate comprising aerosol generating medium, the substrate including a first surface and a second surface facing the first surface; a source of energy for heating arranged to face the second surface of the substrate, wherein the source of energy for heating is configured to cause heating of the aerosol generating medium to form an aerosol; and a movement mechanism arranged to enable movement of the aerosol generating medium relative to the source of energy for heating, wherein the aerosol generating medium is rotationally movable relative to the source of energy for heating such that portions of the aerosol generating medium are presented to the source of energy for heating, and wherein the aerosol generating medium is rotated around an axis at an angle to the first surface.

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.

This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an α-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.

A dry powder inhaler for pulmonary or nasal use, comprising at least an inhaler body (201) and a cartridge (203) with a plurality of powder compartments (205) each including one dose of a drug. The body (201) has an opening (204) shaped for receiving the cartridge (203) and the plastic body recess (215) and the detent (218) to allow a controlled advancement and turning movement of the cartridge (203) relative to the body (201) for sequentially delivering each of the plurality of unit doses filled into the cartridge compartments (205). The inhaler construction is suitable for filling the plurality of unit doses into the compartments (205) with the cartridge (203) assembled into the body (201). The invention affords a large dose inhaler of single-use and low cost that improves industrial filling and manufacturing cost for the delivery of high dosages of inhaled medicines.

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.

A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 μm, so as to target the pulmonary system of the user.

A unit dose capsule for use with a sonic generator includes a deformable membrane adapted to releasably engage the distal end of the elongate horn, a nozzle including at least one delivery opening; a nozzle including at least one delivery opening; and a reservoir containing a liquid composition disposed therebetween. When the unit dose capsule is engaged to the distal end of the elongate horn, the nozzle is disposed in an outwardly facing orientation, and the reservoir is in liquid communication with the at least one nozzle. The unit dose capsule can be included in a kit with a handheld misting device comprising a housing having a dispensing window arranged and configured to contain a sonic generator and a power source.