Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.

Disclosed is a dry powder inhaler for delivering medicament from at least one blister pack, each blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhaler comprises: a housing for accommodating unused and used portions of the at least one blister pack together with a dispensing mechanism for simultaneously opening at least two blister pockets at a time; and a manifold component through which air can be drawn in use of the inhaler. The manifold component comprises: first and second air inlet openings for receiving external air; a first air outlet opening for providing the external air to a first opened blister pocket and a first medicament inlet opening for receiving air-entrained medicament from the first opened blister pocket, the first air outlet opening and the first medicament inlet opening being arranged side-by-side to enable simultaneous communication with the first opened blister pocket; a second air outlet opening for providing the external air to a second opened blister pocket and a second medicament inlet opening for receiving air-entrained medicament from the second opened blister pocket, the second air outlet opening and the second medicament inlet opening being arranged side-by-side to enable simultaneous communication with the second opened blister pocket; and a medicament outlet opening for delivery of the air-entrained medicament from the first and second opened blister pockets to the user, the first and second medicament inlet openings being fluidly connected to the medicament outlet opening by a medicament delivery conduit formed in the manifold component. The first and second air inlet openings are fluidly connected to the first and second air outlet openings by respective first and second air conduits in the manifold component, wherein the air conduits are separately provided so that the external air from each of the first and second air inlet openings does not mix with the external air from the other of the first and second air inlet openings before reaching the first and second opened blister pockets.

A wearable wrist inhaler includes a wristband having a first end and a second end configured for wear about a user's wrist. An inhaler unit is coupled to the wristband displaced from the first end and the second end, the inhaler unit including a housing having a plurality of walls defining an interior area and an outlet port in communication with the interior area. A watch assembly is positioned atop the housing of the inhaler unit, the watch assembly energized by a battery and includes a display configured to indicate a time of day. A dosage chamber including a medicament is positioned in the interior area of the housing. A dispensing assembly is communication with the inhaler medicament that is configured to dispense an individual portion of the medicament via the outlet port upon demand by a user.

A dry powder inhaler (10) having a chamber (26) divided into first and second blister compartments (28, 30) for storing unused and used portions (34, 36) of a blister strip (12) is provided. A moveable dividing wall (32) separates the first and second blister compartments. One or more arcuate supporting surfaces (38, 40, 42) are disposed in either the first and/or the second blister compartments and these surfaces support the used or unused blister strip during successive actuations of the inhaler. Use of the arcuate supporting surfaces facilities compact coils of unused and used portions of blister strip, thereby reducing the size of the chamber required for the inhaler.

Disclosed are dry powder inhalers for delivering medicament to a user from a blister pack, the blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhalers comprise: a housing for accommodating unused and used portions of the blister pack together with a dispensing mechanism for selectively opening the blister pockets; and a manifold component through which air can be drawn in use of the inhaler. The manifold component comprises: a primary air inlet opening for receiving first external air; an air outlet opening for providing the external air from the primary air inlet opening into an opened blister pocket, the primary air inlet opening being fluidly connected to the air outlet opening by a primary air delivery conduit formed in the manifold component; a medicament inlet opening for receiving air-entrained medicament from the opened blister pocket, the air outlet opening and the medicament inlet opening being arranged side-by-side to enable simultaneous communication with the opened blister pocket; and a medicament outlet opening for delivery of the air-entrained medicament from the opened blister pocket to the user, the medicament inlet opening being fluidly connected to the medicament outlet opening by a medicament delivery conduit formed in the manifold component. The disclosed inhalers embodiments provide a variety of improvements to the design of the manifold component.

A medicament dispenser, and a method of assembling a medicament dispenser, for holding at least one elongate form medicament carrier having blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Disclosed is an elongate form medicament carrier and a medicament dispenser. The medicament carrier has a first end, a second end, and a central portion, and carrying multiple distinct medicament dose portions, the medicament dose portions consisting of a first set and a second set of medicament dose portions, the first set of medicament dose portions distributed in a first portion of the elongate form medicament carrier between the first end and the central portion of the elongate form medicament carrier and containing a medicament active, or a mixture of medicament actives, and the second set of medicament dose portions distributed in a second portion of the elongate form medicament carrier between the second end and the central portion of the elongate form medicament carrier and containing a medicament active, or a mixture of medicament actives, wherein the dose portions in the second set of medicament dose portions are different from the dose portions in the first set of medicament dose portions.