Devices, methods, and systems are provided for occluding a collateral flow channel between a target lung compartment and an adjacent lung compartment. A video-assisted thoracoscopic device is inserted into a thoracic cavity of a patient and positioned at a fissure between a target lung compartment and an adjacent lung compartment. A collateral flow channel between the target lung compartment and the adjacent lung compartment is then identified using the video-assisted thoracoscopic device and an agent is injected into the collateral flow channel, thereby reducing the collateral flow channel.

An endobronchial blocker includes an operation box, an extension tube, a ballon, an inflation module, and an elbow module. The extension tube is connected to the operation box. The extension tube has a first passageway and at least one second passageway therein. The ballon is disposed on one end of the extension tube and is in communication with the first passageway. The ballon is in a deflated state during movement. The inflation module is connected to the first passage for supplying a gas to the ballon. The elbow module is assembled to the operation box and includes a pulling means and a control handle. When in use, the control handle is operated to move the pulling means, enabling the extension tube to bend or straighten, thereby reducing the risk of surgical interruption due to poor quality of the left/right lung respiration.