A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system, the gas delivery conduit includes a first connector adapted for connecting to the respiratory gases delivery system, a second connector adapted for connecting to a fitting of a patient interface, tubing fluidly connecting the first connector to the second connector where the first connector has a gas inlet adapted to receive the supplied respiratory gas, one of electrical contacts and temperature contacts integrated into the first connector. The gas delivery conduit further can include a sensing conduit integrated into the gas delivery conduit, where the first connector of the gas delivery conduit is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.

A method of treating a human subject which is effected by inhalation of gaseous nitric oxide, the method comprising a first treatment period comprising administering gNO by inhalation over a period of about at least 5 days, wherein the first treatment period is followed by a second treatment period comprising administering gNO by inhalation over a period of at least 3 months. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.

Oral gas catheters and methods of inducing gas in a patient orally. The oral gas catheter includes one or more delivery cannulas configured to be inserted into the patient's mouth with a distal end of the delivery cannula disposed adjacent the patient's laryngeal inlet, and a clip disposed on the delivery cannula. The clip is configured to secure the delivery cannula to a tooth of the patient. The oral gas catheter may have two such delivery cannulas and clips with the delivery cannulas coupled together by a coupler. The delivery cannulas are placed in an operative position in a patient's mouth and secured in the operative position by releasably securing the clips to the patient's teeth. The oral gas catheter makes it possible to bypass the nasal cavity and deliver oxygen or other gas directly adjacent the laryngeal entrance and into an anatomical dead space of the airway.

A patient valve for ventilating a patient with a ventilator, including a first valve element having at least one connection, wherein the at least one connection is oriented with the central axis thereof at an angle deviating from the vertical position in relation to the patient valve central axis, such that a shortened patient valve having a reduced dead space volume is supported.

Ventilation masks are disclosed herein including a mask body and a gas manifold coupled to the mask body to form a gas channel for directing a gas through a gas port to create a curtain effect gas flow within the patient cavity and form a gas curtain within the patient cavity and adjacent to at least one vent opening formed through the mask body, and a sampling cover couplable with the mask body to form a sampling channel between a sampling portal of the sampling cover and a sensing port, where the sampling portal is formed by a protrusion of the sampling cover that extends into the vent opening and can extend toward a patient cavity formed by an inner surface of the mask body.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

A method of method of high flow oxygen therapy (HFOT) and carbon dioxide (CO.sub.2) monitoring includes delivering high flow oxygen therapy (HFOT) via a central lumen of a nasal cannula, the nasal cannula comprising a proximal end, a distal end positioned within a pharynx region of a patient's airway, and the central lumen and a sampling lumen formed within a wall of the nasal cannula. The method also includes receiving sampled exhaled breath of the patient via the sampling lumen at a CO.sub.2 monitor, wherein the sampling lumen is configured to sample the exhaled breath at the pharynx region through the CO2-permeable membrane and direct the sampled exhaled breath to a CO.sub.2 monitor fluidly coupled to the sampling lumen and determining a level of CO.sub.2 in the exhaled breath using the CO.sub.2 monitor.

A high flow therapy system for delivering heated and humidified respiratory gas to an airway of a patient, the system including a respiratory gas flow pathway for delivering the respiratory gas to the airway of the patient by way of a non-sealing respiratory interface; wherein flow rate of the pressurized respiratory gas is controlled by a microprocessor.

A system for monitoring gas composition in a surgical cavity during an endoscopic surgical procedure includes an gas recirculation system including a main gas flow circuit for fluid communication with a surgical cavity. The system includes a sensor for monitoring a gas species in a gas flow from a surgical cavity of a patient. The sensor is positioned in a channel branching off from the main gas flow circuit coming from the surgical cavity.