A system and process for an oxygen flow control system for supplemental oxygen is provided, including a system with an optical flow sensor and 3-way solenoid that operate to detect inhalation and deliver a microburst of oxygen that is electronically controlled based on one or more parameters.

Disclosed herein are methods, systems, and devices for controlling a gas mixture within a mechanical ventilator. According to one embodiment, a computer implemented method includes receiving first peripheral arterial oxygen saturation (SpO.sub.2) data from a pulse oximeter via a pulse oximeter interface, wherein the pulse oximeter is configured to monitor a patient receiving invasive ventilation; determining a first mode of operation for a ventilator mechanism, wherein the ventilator mechanism is configured to provide at least a portion of the invasive ventilation; determining first partial pressure of oxygen (PaO.sub.2) data stored in a first lookup table using the first SpO.sub.2 data, wherein the first lookup table is derived from a sigmoid shaped oxyhemoglobin dissociation curve; determining first fraction of inspired oxygen in air (FiO.sub.2) data for setting a mixture in a gas blender in the ventilator mechanism based on the first PaO.sub.2 data and a variable offset; and providing the FiO.sub.2 data to the ventilator mechanism.

Systems and methods for calibrating oxygen sensors in ventilators are provided. An oxygen sensor is coupled in flow communication with a first oxygen gas source. A calibration circuit including a second oxygen gas source is coupled in flow communication with the oxygen sensor and a third oxygen gas source is coupled in flow communication with the oxygen sensor. A controller is configured to determine a calibration curve for the oxygen sensor via the calibration circuit by measuring the second oxygen gas source and the third oxygen gas source. Based on the calibration curve, an oxygen concentration value of the first oxygen gas source is measured and distributed.

An oxygen concentrator may have a compressor to feed a feed gas for sieve bed(s) via a first manifold, an accumulator to receive enriched air from the bed(s) via a second manifold. It may include an outer housing for the manifolds, the compressor, and the accumulator. The housing may include an access portal to a compartment therein, for removably receiving the bed(s) as a canister assembly. The first manifold may be adjacent to the compartment and have inlet coupling(s) for removably coupling respectively with inlet(s) of the canister assembly. The inlet coupling(s) may each have a first central axis. The second manifold may be adjacent to the compartment and have outlet coupling(s) for removably coupling respectively with outlet(s) of the canister assembly. The outlet coupling(s) may each having a second central axis. The first and second central axes may form any one of an obtuse, acute, or right angle.

A ventilation adjustment method and a high-frequency ventilation system, which ensure stable and accurate oxygen concentration control within an oxygen concentration setting range, are disclosed. The ventilation adjustment method includes: determining a first gas flow rate control value and a second gas flow rate control value according to a target output flow rate and an oxygen concentration setting value; determining whether the first gas flow rate control value falls into a first dead zone range and whether the second gas flow rate control value falls into a second dead zone range; if the first gas flow rate control value falls into the first dead zone range, maintaining a first gas flow rate controller turned on in an expiratory phase; and if the second gas flow rate control value falls into the second dead zone range, maintaining a second gas flow rate controller turned on in the expiratory phase.

An environment control system utilizes oxygen and humidity control devices that are coupled with an enclosure to independently control the oxygen concentration and the humidity level within the enclosure. An oxygen depletion device may be an oxygen depletion electrolyzer cell that reacts with oxygen within the cell and produces water through electrochemical reactions. A desiccating device may be g, a dehumidification electrolyzer cell, a desiccator, a membrane desiccator or a condenser. A controller may control the amount of voltage and/or current provided to the oxygen depletion electrolyzer cell and therefore the rate of oxygen reduction and may control the amount of voltage and/or current provided to the dehumidification electrolyzer cell and therefore the rate of humidity reduction. The oxygen level may be determined by the measurement of voltage and a limiting current of the oxygen depletion electrolyzer cell. The enclosure may be a food or artifact enclosure.

The invention provides new systems/methods for providing oxygen to chronically ill patients, such as COPD patients, through a more efficient portable oxygen concentrator (“POC”) that at least sometimes delivers an enriched airflow having a significantly lower overall oxygen concentration than that administered by typical POCs. In aspects, the methods/systems of the present invention are configured to automatically switch from pulse delivery to continuous delivery, from continuous delivery to pulse delivery, or any combination thereof, at least once per day, when certain conditions occur. Methods/system can comprise the ability to switch between mode(s) comprising delivery of a moderately enriched oxygen airflow (MEOA) and mode(s) comprising delivery of intensively enriched oxygen airflow, highly enriched oxygen airflow, or both, and back again, based on one or more parameters.

An oxygen concentrator includes one or more adsorbent sieve beds operable to remove nitrogen from air to produce concentrated oxygen gas at respective outlets thereof, a product tank fluidly coupled to the respective outlets of the sieve bed(s), a compressor operable to pressurize ambient air, one or more sieve bed flow paths from the compressor to respective inlets of the sieve bed(s), a bypass flow path from the compressor to the product tank that bypasses the sieve bed(s), and a valve unit operable to selectively allow flow of pressurized ambient air from the compressor along the one or more sieve bed flow paths and along the bypass flow path in response to a control signal. The valve unit may be controlled in response to a command issued by a ventilator based on a calculated or estimated total flow of gas and entrained air or % FiO.sub.2 of a patient.

The present disclosure provides generally for a therapeutic oral device for sleep apnea and associated methods for using the device. According to the present disclosure, the device may comprise a hard palate portion, mouth guard portion, and a tongue retainer portion. The hard palate portion may comprise one or more materials. The hard palate portion may also comprise a composite of materials, including but not limited to embedded materials. The mouth guard portion may comprise one or more components that provide stability and maintain the position of the therapeutic oral device within the mouth. The tongue retainer portion may comprise an airway and a predetermined length. A method of use may comprise the utilization of one or more incremental oral devices to overcome a gag reflex. When the oral device is formed from a mold, the mouth guard portion and the hard palate portion may be custom fit to the dimensions of the intended mouth.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.