An apparatus (1) for supplying a gas mixture to a patient, having a gas inlet line (30) with a gas inlet orifice (30a) that splits into a first gas line (31) and a second gas line (32); at least one permeation module (33) arranged on the second gas line (32), the said permeation module (33) having a feed port (33a) in fluidic communication with the second gas line (32), a retentate port (33b) and a permeate port (33c); a third gas line (34) in fluidic communication with the retentate port (33b) of the permeation module (33); a fourth gas line (35) in fluidic communication with the permeate port (33c) of the permeation module (33), and coupling fluidically to the said first gas line (31); and a source (360) of air in fluidic communication with the first gas line (31) and the fourth gas line (35).

Systems and methods are provided for anesthetic agent level sensing. In one embodiment, a system for an inductive level sensor for an anesthetic vaporizer includes a measurement target positioned around a rod that extends within a chamber configured to hold liquid anesthetic agent, the rod configured to be at least partially submerged in the liquid anesthetic agent and the measurement target configured to slide vertically along a length of the rod and rest on a surface of the liquid anesthetic agent, and a strip of inductive transmitter coils and receiver coils positioned external to the chamber, a length of the strip aligned with the length of the rod, the transmitter coils configured to generate a magnetic field that surrounds the rod and the measurement target and the receiver coils configured to sense changes in the generated magnetic field at a vertical location of the measurement target on the rod.

Systems and methods for producing nitric oxide (NO) to be used in medical applications are provided. In some embodiments, systems and methods are provided for a NO generator that is capable of generating a desired concentration of NO to be provided to a respiratory system for inhalation by a patient.

In one embodiment, the present invention provides a system to deliver at least one therapeutic gas to a spontaneously breathing patient, wherein the rate of delivery of the at least one therapeutic gas exceeds the patient's inspiratory flow rate, and the amount of the at least one therapeutic gas that is wasted is minimized or eliminated.

A method of treating a human subject which is effected by inhalation of gaseous nitric oxide, the method comprising a first treatment period comprising administering gNO by inhalation over a period of about at least 5 days, wherein the first treatment period is followed by a second treatment period comprising administering gNO by inhalation over a period of at least 3 months. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.

A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities.

Various methods and systems are provided for controlling a supply of medical gas to a gas delivery system, such as an anesthesia machine, via a medical gas delivery module. In one example, a method includes supplying a medical gas from a pipeline gas supply source to a gas delivery system via a first conduit, measuring a quality of the medical gas in the first conduit, comparing the measured quality to an allowable range, switching to an alternative gas supply source for supplying the medical gas to the gas delivery system and communicating a pipeline gas supply fault in response to the measured quality being outside of the allowable range, and continuing supplying the medical gas to the gas delivery system from the pipeline gas supply source in response to the measured quality being inside of the allowable range.