Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

A nasal ventilation mask having one or more attachment ports located adjacent to and overlying an upper lip of a patient when worn.

A control system controls fresh gas dispensing for an anesthesia device, with a patient gas-measuring unit, an anesthetic-dispensing unit, a user interface, and a fresh gas regulation unit. With a transition from deactivated assistance mode to activated assistance mode, a processing unit receives a measured signal, a fresh gas signal and an assistance signal and calculates an end tidal anesthetic concentration over time based on a current volume flow, a predefined volume flow and on a current end tidal anesthetic concentration and stores this as a preset curve. A fresh gas correction signal is output upon the determined current end tidal anesthetic concentration leaving a surrounding range of the preset curve. A predefined volume flow curve is changed as a function of the correction signal. The volume flow of fed fresh gas is increased when the surrounding range is undershot and is reduced when the surrounding range is exceeded.

The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NO.sub.2 to NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO2-to-NO reactor cartridge and/or a break-through of NO.sub.2, and providing an indication of the remaining useful life and/or break-through.

A process (10), with a computer program, a device (30) and a ventilation system (40) detect a leak in a patient gas module, which suctions and analyzes a continuous sample gas stream from a ventilated patient (20), in a ventilation system for ventilating a patient (20). The process includes a determination (12) of a first time curve of a carbon dioxide concentration in a breathing gas mixture of the patient (20) and the determination (14) of a second time curve of a concentration of another gas in the breathing gas mixture, which gas is different from carbon dioxide. The process (10) further includes a determination (16) of a statistical similarity indicator between the first time curve and the second time curve and the detection (18) of the leak based on the similarity indicator.

Systems and methods are provided for delivering anesthetic agent to a patient. In one embodiment, an anesthetic vaporizer includes a housing defining a sump, the sump configured to hold a self-contained supply of liquid anesthetic agent, a heating element electrically coupled to an electrical mating component, a gas inlet passage and a gas outlet passage, a manifold fluidically coupled to the gas inlet passage and the gas outlet passage, the manifold coupled to the housing and forming a gas-tight seal with the sump, and a quick disconnect pneumatic system coupled to the gas inlet passage and the gas outlet passage, sealing the gas inlet passage and the gas outlet passage from atmosphere.

A method of treating a human subject which is effected by inhalation of gaseous nitric oxide over a period of 8 day to about 28 days is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract. The disclosed method can be effected while monitoring one or more of on-site and off-site parameters such as vital signs, methemoglobin levels, pulmonary function parameters, blood chemistry and hematological parameters, blood coagulation parameters, inflammatory marker levels, liver and kidney function parameters and vascular endothelial activation parameters, such that no substantial deviation from a baseline in seen in one or more of the monitored parameters.

A system for tracking anesthetic agent in a vaporizer reservoir can include a mass flow sensor configured to measure a flow rate entering or exiting a vaporizer chamber, a gas pressure sensor configured to measure a pressure of a mixed gas provided from the vaporizer chamber, and a processor to calculate a remaining agent time based on at least the gas flow rate, the pressure of the mixed gas, and an anesthetic concentration in the mixed gas. The processor can also provide the remaining agent time for display to a clinician.

Methods and systems are provided for delivering anesthetic agent to a patient. In one embodiment, a liquid anesthetic agent container includes a base region, an interior of the base region configured to hold liquid anesthetic agent, an adapter region, and a capillary force vaporizer (CFV) housed in the adapter region. The adapter region includes a coupling end configured to couple to a patient breathing circuit to supply anesthetic agent vaporized by the CFV to a patient.

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.