Systems are provided for a vaporizer gas mixer. The system includes a one-piece body; a gas inlet passage and a gas outlet passage; a first flow path fluidically coupled to the gas inlet passage and the gas outlet passage, the first flow path having a plurality of curves; and a second flow path fluidically coupled to the first flow path and a vaporizing chamber, wherein the first flow path and the second flow path merge after the gas inlet passage and before the plurality of curves. The second flow path includes curves extending in different planes.

Disclosed is a device for supplying therapeutic gas, notably NO/N.sub.2 or O.sub.2/N.sub.2O mixtures, including an internal passage with a valve for conveying and controlling the flow of therapeutic gas in the internal passage, a control unit controlling the valve, a graphic display for displaying choices that can be selected by a user, and a selector, such as touch-sensitive keys displayed on the graphic display for making a selection from among the selectable choices displayed on the graphic display. The control unit is configured to count a total number of patients treated by administration of the therapeutic gas from the selection, by a user, via the selector, of a first given choice corresponding to the start of a treatment by administering the therapeutic gas to a patient concerned.

An anesthetic dispensing device (100) includes a measuring unit (150) for determining an anesthetic concentration in an area of an outlet (142) of the anesthetic dispensing device. The measuring unit is configured to measure a first parameter (154) of a gas concentration-dependent characteristic between a mixer unit (140) and a second parameter (155) of the gas concentration-dependent characteristic in a second gas branch (120) or in an area of a breathing gas feed (112) of the anesthetic dispensing device by at least one sensor element (152). The measuring unit is further configured to determine the anesthetic concentration between the mixer unit and the outlet and to output a corresponding concentration signal (160) as a function of calibration information assigned to the second parameter and of the first parameter.

A filler device includes a distal housing comprising a distal inner port and a distal outer port; a proximal housing comprising a proximal inner port and a proximal outer port, the proximal housing being sealingly affixed to the distal housing to form an inspiratory pathway between the distal inner port and the proximal inner port and to form an expiratory pathway between the distal outer port and the proximal outer port that is fluidly sealed from the inspiratory pathway, the inspiratory pathway being laterally adjacent the expiratory pathway; and a first filter in the inspiratory pathway or in the expiratory pathway to filter gases flowing through the inspiratory pathway or the expiratory pathway.

Systems and methods for generating nitric oxide are disclosed. A nitric oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles.

A nasal ventilation mask having one or more attachment ports located adjacent to and overlying an upper lip of a patient when worn.

A method of ventilator control that includes receiving machine data from a mechanical ventilator and detecting one or more clinical events in the received machine data. The method further includes evaluating the machine data within the detected one or more clinical events for compliance with lung protective ventilation (LPV) recommendations. The method further includes at least one of producing a visual indication or a graphical display of the evaluated compliance with the LPV recommendations and controlling the mechanical ventilator based on the evaluated compliance with the LPV recommendations.

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.