A patient interface to deliver a flow of air at a positive pressure with respect to ambient air pressure to an entrance to the patient's airways to ameliorate sleep disordered breathing includes a frame assembly and a cushion assembly configured to removably and repeatably connect to the frame assembly. The frame assembly and the cushion assembly form at least part of a plenum chamber pressurizable to a therapeutic pressure. The cushion assembly comprises a one-piece construction including a seal-forming structure configured to form a seal with a region of a patients face surrounding the entrance to the patients airways and a frame connection structure configured to removably and repeatably connect the cushion assembly to the frame assembly. The seal-forming structure comprises a first elastomeric material and the frame connection structure comprises a second elastomeric material, the first elastomeric material comprising a lower durometer or hardness than the second elastomeric material.

Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.

A heat and moisture exchanger device comprising a housing containing a microcurrent-generating filter capable of generating a low level microcurrent. A microcurrent-generating filter can reduce the number of living or active microbes.

Embodiments of the present invention provide systems and methods for delivering respiratory treatment to a patient. For example, a treatment system may include a mechanism for delivering a positive pressure breath to a patient, and one or more limb flow control assemblies which modulate gas flow to and from the patient. Exemplary treatment techniques are embodied in anesthesia machines, mechanical ventilators, and manual ventilators.

A system and process for the recovery of at least one halogenated hydrocarbon from a gas stream. The recovery includes adsorption by exposing the gas stream to an adsorbent with a lattice structure having pore diameters with an average pore opening of between about 5 and about 50 angstroms. The adsorbent is then regenerated by exposing the adsorbent to a purge gas under conditions which efficiently desorb the at least one adsorbed halogenated hydrocarbon from the adsorbent. The at least one halogenated hydrocarbon (and impurities or reaction products) can be condensed from the purge gas and subjected to fractional distillation to provide a recovered halogenated hydrocarbon.

In a first embodiment, a ventilator has a housing with a first fixed port and a rotatable shutter configured to cooperate with the housing to enclose an interior of the housing. The shutter has a first orifice at a first radial distance from its axis of rotation. A stationary plate abuts the shutter and includes a first stationary orifice configured to at least partially align with the first orifice of the shutter over a first rotational distance of the shutter. In this way, the first orifice and the first stationary orifice form a first variable port. The stationary plate may have a second stationary orifice and the shutter may have a second orifice configured to at least partially align with the second stationary orifice over a second rotational distance of the shutter.

A respiratory device provides respiratory support to a patient. The respiratory device includes an expandable bag and a rigid valve housing. The expandable bag has an air inlet valve as well as a first and second sides that are bounded, respectively, by first and second rigid side panels. Each of the first and second rigid side panels includes a biasing member projection. The rigid valve housing is in fluid communication with the expandable bag. The rigid valve housing includes an adjustable tidal volume control device that interfaces with the biasing member projection of each of the first and second rigid side panels to set one of a plurality of predetermined tidal volumes for the expandable bag in an uncompressed or compressed configuration. The rigid valve housing additionally includes a patient breathing interface connection member.

Apparatus and methods are described, including a water trap (28) that includes an inlet portion (40), via which a mixture of gas and water is configured to enter the water trap, and an outlet portion (42), via which the gas is configured to exit the water trap, the inlet portion and the outlet portion being formed separately from one another and being coupled to one another, such as to form a tube (44) that defines a longitudinal axis and that defines an internal hollow volume through which the gas is configured to flow. A membrane filter (46) is disposed in a flat configuration within the tube, between the inlet portion and the outlet portion, such that the membrane filter is substantially parallel to the longitudinal axis of the tube, the membrane filter being configured to prevent the water from passing therethrough. Other applications are also described.

Introduced here is a self-contained face mask system with an automated liquid-droplet dispensing mechanism (ADM) for humidification. The enclosure of the self-contained mask system can be comprised of one or more layers of breathable fabric adapted to flexibly conform to the face of a user when worn to form a cavity that is adjacent the nostrils and mouth. The ADM of the face mask system can be comprised of a reservoir in which liquid is stored, a respiratory cycle detector, a timer and controller, and a droplet dispenser that controllably dispenses droplets of the liquid from the reservoir into the cavity for inhalation by the user. The ADM can be contained entirely within the face mask enclosure or supported on the surface of the face mask enclosure such that the self-contained mask system, when worn by a user, can be supported entirely by the head and neck of the user.

A ventilation system that includes a pressure source, a pneumatic path configured to receive gas from the pressure source and comprising a first pneumatic component coupled to a second pneumatic component. The first pneumatic component includes a first electrical conductor including a first electrical component having a first electrical characteristic. The second pneumatic component comprises a second electrical conductor including a second electrical component having a second electrical characteristic. The first electrical conductor is electrically connected with the second electrical conductor in an electric path. The system performs operations including determining a continuity of the electrical path; displaying a notification regarding the continuity of the electrical path; detecting the unique electrical characteristic of the electric path; and determining a pneumatic characteristic of the pneumatic path.