A portable medical ventilator using pulse flow from an oxygen concentrator to gain higher oxygen concentration includes a positive pressure source to deliver pressurized air to the patient and a negative pressure source to trigger the oxygen concentrator. A patient circuit attached to a patient interface mask connects the ventilator to the patient. The ventilator includes a controller module that is configured to generate a signal to the negative pressure device to trigger the concentrator to initiate one or more pulses of oxygen from the oxygen concentrator. The oxygen pulses are delivered to the patient interface directly through multi-tube or a multi lumen patient circuit. The oxygen does not mix with air in the ventilator or in the patient circuit and bypasses the leaks in the patient circuit and/or patient interface.

Described herein are methods which involve minimizing or eliminating the occurrence of delayed negative effects that may arise from exposure to reduced oxygen partial pressure. An amount of supplemental oxygen, which substantially mimics a target oxygen partial pressure, is administered to an individual that is exposed to a reduced oxygen partial pressure environment, to compensate for the reduced oxygen partial pressure. The target partial pressure may be selected such that the individual experiences substantially no change in the oxygen partial pressure. Individuals receiving the supplemental oxygen may be healthy, have special sensitivities, or have a pre-existing neurological condition.

There is a ventilator for mechanical ventilation during a breathing cycle including an inhalation cycle and an exhalation cycle. The ventilator is configurable to be in fluid communication with a supply of a first fluid. The ventilator includes an inhalation pathway and an exhalation pathway. A first fluid injector is in fluid communication with the supply of the first fluid for injecting the first fluid. The inhalation pathway receives the first fluid injected by the first fluid injector. A controller is operatively connected with the first fluid injector and programmed to selectively actuate the first fluid injector to inject the first fluid, which is received within the inhalation pathway such that an inhalation pressure in the inhalation pathway is within a predetermined range during the inhalation cycle.

A system for providing a NO-containing gas flow to treat a biological object. The system includes a nozzle receptacle for receiving NO-rich air from a plasma-generated NO source, tubing coupled to the nozzle for directing the NO-rich air to a scrubber, the scrubber configured to receive a solvent for absorbing NO2, tubing coupled between the scrubber and a gas mixer for directing scrubbed NO-rich air to the gas mixer, where the gas mixer is coupled to a source of atmospheric air for selectively mixing the scrubbed NO-rich air with the atmospheric air to create diluted NO-containing air; and a manifold for distributing the diluted NO-containing air to a plurality of patient locations.

Resuscitation/ventilation systems that include a pressure chamber or cylinder may use a piston articulated within the pressure chamber or shaft to push air and/or a mixture of gas and air into and out of an airway circuit for the purpose of providing mechanical ventilation and/or artificial respiration to a patient. In some cases, the pressure chamber or cylinder may be resident within a canister that fits with a body. The canister may include a motor that moves a shaft connected to the piston up and down, or in and out, within the pressure chamber or cylinder and this movement of the piston may cause a vacuum within the airway circuit and/or the pushing of air or gas out of the airway circuit into a patient’s lung(s).

Described herein are improved assisted ventilation interfaces along with methods and uses thereof. The interfaces comprises a hood embodiment with altered design aspects to decrease or even avoid the risk of leakage and potential viral transmittance along with providing other benefits. In one aspect, the patient interface comprises a hood with a free-breathing valve and an integral viral filter. The free-breathing valve and viral filter may be separate to or integral to the exhaust port. In a further embodiment multiple branches may be used from the exhaust port with multiple viral filters. In a further embodiment, an internal pressure gauge may be used. In a further embodiment dual air sources may be used.

A system for delivering oxygen to a substantially stationary patient without coupling a device to the body of the patient is disclosed. The system includes a source of oxygen coupled to a delivery system wherein the delivery system has a pump configured to pressurize oxygen and an elongate hollow member operatively coupled to the pump. The elongate hollow member has a proximal end and a distal end and is constructed to receive oxygen in its proximal end and deliver oxygen to the patient out the distal end. The length and diameter of the elongate member, the flow of oxygen through the elongate member, and the distance from the distal end of the elongate member to the face of the patient are optimized to collimate a stream of oxygen such that when the stream of oxygen reaches the patients face it envelops the face of the patient.

The present disclosure provides a ventilator that includes a first gas path, comprising a first pressurized gas source adaptor and a first flow adjustment device connected in sequence; a second gas path, comprising a second pressurized gas source adaptor and a second flow adjustment device connected in sequence; a third gas path, comprising a third pressurized gas source adaptor; a first inhalation branch for delivering inhalation gas to a patient; a second inhalation branch for delivering inhalation gas to the patient, including a gas compression device; a switching device, including a first mixing mode connecting the first gas path and the second gas path to the first inhalation branch, and a second mixing mode connecting the first gas path and the third gas path to the second inhalation branch; and an exhalation branch for managing exhaled air of the patient.

Medical gas delivery devices are provided. A garment or another object may include a hose assembly configured to couple the garment or the object to a medical gas source. The garment or the object can be configured to deliver a medical gas to a patient. Additionally, medical gas delivery devices configured to be removably coupled to a garment or another object are provided.

Devices for delivering a controlled concentration of an agent are provided. The device includes a reservoir for the agent and a flow control portion operably connected to the reservoir. The device also includes a valve for releasing the agent from the flow control portion and a pump for flowing air to mix with the agent released by the valve and for flowing the agent and air mixture out of the device. Methods of delivering a vaporized agent to a subject are also provided. The methods include storing a liquid agent in a reservoir of a device and flowing the agent into a flow control chamber to change the agent to a gas. The methods also include mixing the agent in gas form with air and flowing the agent and air mixture out of the device to be delivered to a subject.