A system for aspirating thrombus includes an aspiration catheter including a supply lumen and an aspiration lumen each extending within an elongate shaft, and an opening at or near the distal end of the supply lumen, the opening configured to allow the injection of pressurized fluid into the aspiration lumen at or near the distal end of the aspiration lumen when the pressurized fluid is pumped through the supply lumen, a tubing set including tubing and having a distal end configured to couple to the aspiration lumen of the aspiration catheter and a proximal end configured to couple to a vacuum source, a tubing compression element configured to externally engage the tubing of the tubing set, and an activation interface configured to activate the tubing compression element to compress the tubing at a location between the proximal end of the tubing set and the distal end of the tubing set.

A system for aspirating thrombus including an aspiration catheter including a supply lumen and an aspiration lumen, the supply lumen having a proximal end and a distal end, the aspiration lumen having a proximal end and an open distal end. An opening at or adjacent the distal end of the supply lumen, in fluid communication with the interior of the aspiration lumen, is located proximally of the open distal end of the aspiration lumen. The opening is configured to create a jet when pressurized fluid is pumped through the supply lumen. A connector is hydraulically coupled to the proximal end of the aspiration lumen, the connector having an interior cavity, a proximal end and a distal end.

A method for removing thrombus from a patient, the method including providing an aspiration catheter having a supply lumen, an aspiration lumen, an opening at or adjacent a distal end of the supply lumen, and a connector hydraulically coupled to the aspiration lumen, the connector having an interior cavity. The method includes placing the aspiration catheter through an inner lumen of a guiding catheter and into the blood vessel, coupling the aspiration catheter to a fluid source and a vacuum source, causing an injection of fluid from the fluid source through the supply lumen via a first pump with the vacuum source actively coupled to the aspiration lumen, and determining that aspiration of the thrombus through the aspiration lumen is not occurring at a desired thrombus aspiration rate.

A system for aspirating thrombus including an aspiration catheter including a supply lumen, an aspiration lumen, an opening at or adjacent a distal end of the supply lumen, in fluid communication with an interior of the aspiration lumen, the opening located proximally of an open distal end of the aspiration lumen. The opening is configured to create a jet when pressurized fluid is pumped through the supply lumen. A connector is hydraulically coupled to the aspiration lumen, the connector having an interior cavity having an inner surface, a proximal end and a distal end, wherein the connector includes a first sideport communicating with the interior cavity of the connector and in fluid communication with the aspiration lumen, and wherein the first sideport includes the nearest significant interruption of the inner surface to the distal end of the connector.

A first connector configured for removable connection proximal to an aspiration catheter, the first connector comprising a body having an interior, a distal end comprising a connection configured to sealably couple to a aspiration lumen of the aspiration catheter, a proximal end comprising an openable and closable seal configured for sealing over a guidewire, an aspiration port in fluid communication with an interior of the body and configured to couple to a vacuum source, and a pressure sensor in fluid communication with the interior of the body.

A method for removing thrombus from a patient that includes providing an aspiration catheter including a supply lumen and an aspiration lumen, with a connector hydraulically coupled to the proximal end of the aspiration lumen, the connector having an interior cavity, a proximal end and a distal end. The method further includes coupling or causing to couple the supply lumen of the aspiration catheter to a fluid source, coupling or causing to couple the aspiration lumen of the aspiration catheter to a vacuum source, and coupling or causing to couple a pump for injecting fluid from the fluid source through the supply lumen and through the opening into the aspiration lumen. The method includes setting a pump with a control unit such that an input pressure of the supply lumen is between about 650 pounds per square inch and about 1200 pounds per square inch.

In vivo positionable filtration devices are provided that filter one or more therapeutic agents in blood flowing in a blood vessel. The filtration devices include an elongated member and a filtering component coupled to the elongated member. The elongated member and the filtering component are dimensioned for positioning within a blood vessel of a human or non-human animal. Further, the filtering component includes a filtration material to filter the one or more therapeutic agents from blood. Methods of in vivo filtration of one or more therapeutic agents are also provided. The methods include positioning a filtration device in a blood vessel of a body of a human or non-human animal, and administering a therapeutic agent upstream from the target tissue site to direct flow of the therapeutic agent to the target tissue site and then to the filtration device. The filtration device is positioned downstream from a target tissue site.

A minimally invasive system for monitoring and treating high intracranial pressure levels resulting from traumatic brain injury comprises an intravenous access device, an elongate member, a console, and an aspiration and injection catheter. The system is capable of monitoring pressure levels and relocating fluid from the brain to another part of the patient's body to sustain overall constant fluid volume. The method of using the minimally invasive system is also described.

A subcutaneous tunneling device includes a shaft having a bend, a catheter connector extending from a distal end of the shaft distal of the bend, and a sleeve. The catheter connector can include a body having a gripping portion, and a barbed extension distal of the body configured for insertion into a lumen of a catheter. The sleeve is slidably mounted on the shaft, and has a retracted position exposing the catheter connector to permit a distal end of a catheter to be coupled thereto, and an extended position covering the catheter connector and the distal end of the catheter.

A catheter includes: a catheter body defining: a first lumen communicating with a first distal opening, and a second lumen communicating with a second distal opening. The second distal opening is positioned proximal of the first distal opening. A flow path cross-sectional area of the first lumen in at least a part of a distal region of the catheter body that is distal of the second distal opening is larger than a flow path cross-sectional area of the first lumen in a proximal region of the catheter body that is proximal of the second distal opening.