A method for aspirating thrombus in a subject, the method including providing an aspiration catheter having a supply lumen, an aspiration lumen, and a first connector hydraulically coupled to the aspiration lumen. The method further includes providing a pressure sensor having an internal passageway and having a distal connector configured to hydraulically couple to the first connector, a proximal connector configured to couple to a vacuum source, and a valve disposed between the distal connector and the proximal connector, the valve having an open state and a closed state. Following inserting at least a distal portion of the aspiration catheter into the vasculature of a subject, changing the valve from one of the open state and closed state to the other of the open state and closed state such that a change in pressure may be detected by the control circuitry.

A medical device may include a catheter, an expandable member, a cover, and an actuator. The catheter may include a longitudinal axis, proximal and distal ends, and a cover lumen extending from the proximal to the distal end. The expandable member may include proximal and distal ends and may be disposed on a distal section of the catheter. The cover may include a first region that may be disposed along the expandable member, and a second region that may extend along a length of the catheter beyond the proximal end of the expandable member towards the proximal end of the catheter. A first end of the cover may invert into the cover lumen. The actuator may be coupled to the first end of the cover and configured to move the first end of the cover towards the proximal end of the catheter along the longitudinal axis of the catheter.

The present invention provides a bi-directional perfusion cannula for use in peripheral veno-arterial extracorporeal membrane oxygenation of a patient, the cannula comprising a cannula main body having a primary lumen, the primary lumen leading to a distal end of the cannula main body for providing retrograde blood perfusion, characterized in that the main body further comprises a passage for passing a second cannula therethrough, the passage being oriented such that when a second cannula is inserted into the passage the second cannula is arranged for providing anterograde blood perfusion.

An endovascular apparatus including a stabilizing element and a rod that may be detachably coupled to the stabilizing element. The rod may be elongated along a longitudinal axis. The rod may have at least one therapeutic agent thereon. The therapeutic agent may be an enzyme, an antibody, a biomarker, or a bioreceptor for neutralizing components of a bodily fluid of a patient. The rod may be inserted into the patient's body to place the therapeutic agent into fluid communication with the patient's bodily fluid. The rod may be formed from silicone and an outer surface of the rod may be etched prior to coating the rod with the therapeutic agent.

Disclosed is an angioplasty balloon catheter and method of use, said angioplasty balloon catheter includes an elongated tip end with physical characteristics nearly identical to a standard angiographic diagnostic catheter. The elongated tip end extends approximately between 2 cm to 75 cm beyond a distal end of a balloon, depending upon embodiments. The tip of the elongated tip end may be angled or straight depending upon embodiments and may or may not have a plurality of side holes in addition to an end hole depending on embodiments. The elongated tip end permits the angioplasty balloon catheter to tract more easily across tortuous or markedly angulated segments of a dialysis graft or fistula, minimizing complications that can result with currently available devices. If angulated, the elongated tip end also enables a user to selectively catheterize an artery without needing a separate diagnostic catheter to do so, and enable tracking and cornering across sharply angulated vessel segments. Whether with an angled or straight distal catheter portion, the angioplasty balloon catheter disclosed herein allows the user to perform angioplasty of an inflow segment of a dialysis graft or fistula and then perform post angioplasty angiographic imaging without the need to exchange the angioplasty balloon catheter for a diagnostic catheter, advance the balloon catheter into the native artery, or perform a blowback angiographic run, thereby improving safety and reducing procedure time.

A multi-lumen implantable device configured to deliver a therapeutic agent to a selected portion of a blood vessel is disclosed. As one example, an implantable device includes a first lumen configured to flow blood from an upstream end to a downstream end of the device when implanted in a blood vessel; a second lumen fluidly separated from the first lumen and configured for introducing a therapeutic agent to a selected, first portion of a wall of the blood vessel, between the upstream end and the downstream end of the device; and at least one sealing member configured to block the therapeutic agent from entering a second portion of the wall of the blood vessel, between the upstream end and the downstream end of the device.

A delivery device may comprise a sheath configured to be inserted into a body lumen of a patient. The sheath may have a proximal end, a distal end, a first channel extending within the sheath from the proximal end to the distal end, and a second channel extending within the sheath from the proximal end to the distal end. A collective cross-sectional area of the first channel and the second channel may be more than 50% of a total cross sectional area of the sheath. The device may also be comprised of a handle at the proximal end of the sheath, wherein the handle is configured to provide fluid communication between a first port and the first channel and a second port and the second channel.

Disclosed herein is a drug-coated balloon catheter including: a hub; a soft tip; a tube which connects the hub and the soft tip and is formed of a material having higher rigidity than the soft tip; and a balloon which is mounted on the tube and coated with a drug on the surface, wherein the tube includes: a guide lumen which allows a guide wire to be movable, the guide wire being inserted into a blood vessel via the hub; and an injection lumen into which a contrast medium is injected, the contrast medium being injected into the balloon through the hub or discharged therefrom, wherein the injection lumen includes: a flow center which is a portion corresponding to a width of the guide lumen; and a pair of bend supports which is extended beyond both end portions of the guide lumen on both sides of the flow center and deformed in response to bending of the tube, and the injection lumen has a cross-sectional area more than a half of a cross-sectional area of the guide lumen.

A system for delivering a fluid to a Eustachian tube (ET) of a patient includes a guide member and a tubular member. The guide member includes a shaft having a proximal portion, a distal portion, and a bend at the distal portion. The bend is configured to provide access to an opening in the ET. The system further includes a tubular member comprising a proximal end, a distal end, and a lumen extending therebetween. The tubular member is sized to fit within the ET. One or both of the tubular member and the guide member comprises a first stop member configured to engage the other of the tubular member or the guide member. The first stop member is configured to restrict a distal advancement of the tubular member relative to the guide member.

Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes inserting an intramural crossing device into the vascular lumen, positioning at least the distal tip of the crossing device in the vascular wall, advancing an orienting device over the crossing device such that an orienting element of the orienting device resides in the vascular wall, inserting a reentry device, and re-entering the true vascular lumen.