Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting. Ultimately this leads to reduced complications, enhanced therapy, and the elimination of the need for awake surgery. The method and system provides the capability heretofore not possible to visualize the small, often indistinct regions, which will greatly improve clinical outcomes with therapeutic interventions.

An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve. For example, such a device may be used to measure fractional flow reserve (FFR) across a stenotic lesion in order to assess the severity of the lesion. The sensor delivery device has a distal sleeve configured to pass or slide over a standard medical guidewire. Some distance back from the sensor and distal sleeve, the device separates from the guidewire to permit independent control of the sensor delivery device and the guidewire. The sensor delivery device can be sized to pass over different sizes of guidewires to enable usage in coronary and peripheral arteries, for example.

Embodiments of the invention provide apparatus, systems and method for introducing fluids into a body cavity for treatment. One embodiment provides an apparatus for treating a patient including an access device for insertion into the peritoneal cavity of the patient including an infusion member in a lumen of the access device. An oxygenated solution may be infused and removed into and out of the cavity via the infusion member.

Disclosed is a balloon catheter that can prevent or reduce axial rotation and circumferential shift of the elongate body while ensuring good passage of the balloon in the blood vessel. The balloon catheter (100) has a shaft (110); a balloon (120); an elongate body (180) extending along the shaft (110) and having a body tissue contacting part at its distal end part; and an elongate body lumen (130), the elongate body lumen (130) having a first engagement part (131) so that axial rotation angle of the elongate body (180) is 0° to 60°, and the first engagement part (131) being located between the distal end (130d) of the elongate body lumen (130) and a position 30 cm from the distal end of the elongate body lumen (130) toward the proximal side.

An apparatus and methods tissue restoration are provided. The apparatus may include a catheter shaft extending from a proximal end to a distal tip and a translucent first distal balloon positioned on a translucent distal segment of the catheter shaft inside of and concentric with a second distal balloon proximal to the distal tip in fluid communication with a drug source via a first lumen, the first distal balloon may include first and second outer surfaces, and longitudinal and circumferential channels. A first light fiber and a second light fiber each positioned in the catheter shaft and extending through the translucent distal segment. The drug source provides at least one drug to the first distal balloon via the first lumen.

A valve connector for a tunable valve is disclosed, with tunable features to allow for optimization. The tunable valve can include slits, which may be preferentially placed, angled and sized to optimize the crack pressure, maintenance pressures, and clearance characteristics of the connector. The tunable valve may also include a recess in the area of an exemplary center slit, which may be sized further modify the characteristics of the connector valve. The valve may be preferentially curved along either a lateral axis or a transverse axis. The tunable valve may be a proximal valve that is capable of being secured between proximal housing and distal housing. The proximal housing opening may be preferentially shaped.

A multi-lumen catheter including an elliptical cross-sectional profile configuration that enhances fluid flow rate while minimizing the average diameter of the catheter body is disclosed. In one embodiment the catheter includes an elongate catheter tube defining a plurality of lumens. At least a portion of the longitudinal length of the catheter tube may define an elliptical cross section, in turn defined by a major axis and a minor axis. In one embodiment, a ratio of the major axis to the minor axis of the elliptical cross section is between about 1.3 and about 1.4. The catheter body can define two, three, or more lumens. In one embodiment, a dual-lumen catheter tube includes an aspect ratio of about 1.1:1, and each lumen thereof includes an inner surface defined by a plurality of radii and an hourglass-shaped septum.

A method of making a multi-lumen catheter may include disposing an outer surface of a mandrel against an outer surface of a first catheter; disposing a first heat shrink material around the first catheter and the mandrel; heating the first catheter and the mandrel to form a U-shaped channel along the outer surface of the first catheter; removing the first heat shrink material and the mandrel from the first catheter; placing a second catheter into the U-shaped channel; disposing a second heat shrink material around the first catheter and the second catheter such that the second catheter is retained within the U-shaped channel; and heating the first catheter and the second catheter to cause reflow between the first catheter and the second catheter to form the multi-lumen catheter.

A catheter assembly including an elongate catheter tube is disclosed. The number of lumens defined by the catheter tube can vary as a function of longitudinal length along the catheter tube. For instance, the catheter tube can define three lumens from the proximal end of the catheter tube and terminate one of the lumens at an intermediate termination point such that only two lumens are defined further distally along the catheter tube. A sensor can be placed in the terminating lumen so as to isolate it from the other lumens and from blood or other body fluids while still enabling the sensor to reside within the patient body when the catheter tube is positioned in the patient for use. In addition to this, various other lumen transition and sensor configurations are disclosed.

Embodiments of the invention are directed towards a rapid exchange catheter configured for insertion into a subintimal space and crossing an occlusion in a subintimal space. The catheter includes a proximal end, a distal end, a first lumen configured to receive a first wire, the first lumen extending longitudinally through a least a lateral port of the catheter, and a second lumen having at least a portion distal of the lateral port and extending through at least the distal end of the catheter. The catheter also includes an exchange port arranged on a exterior portion of the catheter configured to the receive a second wire and second rapid exchange port in communication with the second lumen. Moreover, other embodiments of the invention are directed towards methods for using the rapid exchange catheter to cross an obstruction in a vessel, e.g., a total or partial occlusion, in a subintimal space.