A drug-delivery cannula assembly includes a cannula housing adapted for receiving at least one obturator shaft of an obturator assembly therethrough, one or more cannulae, and a supply line coupled to the cannula housing. The cannula housing is adapted for receiving one or more obturator shafts of an obturator assembly therethrough. The one or more cannulae define a longitudinal axis and a passageway aligned with the longitudinal axis. The one or more cannulae each include a proximal end coupled to the cannula housing. The cannula housing is configured to fluidly-couple the one or more cannulae to a source of a drug delivery supply for supplying drugs via the supply line to the one or more cannulae.

A biologics delivery device and method of use for promoting angiogenesis in occluded vessels and ischemic tissue of a patient are provided, wherein the biologics delivery device includes a catheter having a proximal end, a distal region having a distal end, a lumen extending there between, and a plurality of through-wall apertures distributed along the distal region, the plurality of through-wall apertures in fluid communication with the proximal end and the lumen, and an expandable member disposed in the distal region, the expandable member configured to transition between a collapsed state and an expanded state. Methods of using the inventive biologics delivery device also are provided to achieve substantially uniform distribution of the biologic into a subintimal space.

A urinary catheter is readily removed and replaced with a second urinary catheter without introducing foreign matter or contaminants into the bladder. The first urinary catheter includes an extra lumen that houses a sheath, which sheath seals the extra lumen from introduction of fluids. The sheath seals an opening or third hole at or near the tip of the catheter. After the sheath seal is broken and the sheath is extracted from the catheter, a guidewire is threaded through the extra (third) lumen and into the patient's bladder. The first urinary catheter is withdrawn from the patient, leaving the guidewire in the patient. A second urinary catheter is inserted into the patient over the guidewire, with the guidewire present in the urine lumen of the second urinary catheter. The guidewire then is extracted from the patient. The second urinary catheter may also have an extra or third lumen and a sheath with a break-away seal so that the second urinary catheter may be removed and replaced in like manner.

Disclosed are rapidly insertable central catheters (“RICCs”) including assemblies and methods thereof. In some embodiments, a RICC assembly includes a RICC and an introducer. The RICC includes a soft catheter tube having an introducing aperture that opens into a primary lumen of the RICC. The introducer includes an introducer catheter including a hard catheter tube having an introducing hole that opens into a single lumen of the introducer catheter. When the RICC assembly is in a ready-to-deploy state thereof, the introducer catheter is disposed in the primary lumen of the RICC such that a distal end of the introducer catheter extends past a distal end of the RICC. In addition, an introducer needle of the introducer is disposed in the introducer catheter through both the introducing aperture and the introducing hole such that a beveled tip of the introducer needle extends past the distal end of the introducer catheter.

Disclosed herein are two-piece catheters and methods thereof. For example, a two-piece catheter can include a proximal catheter piece and a distal catheter piece. The proximal catheter piece includes a proximal catheter-hub piece and one or more extension legs respectively including one or more extension-leg lumens. Each extension leg of the one-or-more extension legs is coupled to the proximal catheter-hub piece by a distal-end portion of the extension leg. The distal catheter piece includes a distal catheter-hub piece and a catheter tube including one or more catheter-tube lumens. The catheter tube is coupled to the distal catheter-hub piece by a proximal-end portion of the catheter tube. The two-piece catheter has a connected state in which the proximal catheter-hub piece is connected to the distal catheter-hub piece such that the one-or-more catheter-tube lumens are respectively fluidly connected to the one-or-more extension-leg lumens across a two-piece catheter hub.

Clot removal from a patient's vessel, such as an artery, are described using aspiration and hydraulic forces supporting the removal process. Hydraulic forces can be generated by occluding the vessel distal to the clot and delivering liquid between the clot and the occlusive device. The aspiration catheter is positioned proximal to the clot. Catheters designed to facilitate the delivery of hydraulic forces can be based on single lumen designs or dual lumen designs. The catheters may have a fixed internal wire, or in some embodiments the catheters can ride over a wire with a valve/seal positioned to restrict flow into or out from the guide lumen such that the guide lumen can further function for balloon inflation and/or for infusion of liquid.

A venous catheter assembly includes a hub with opposing suture wings, an extension leg coupled to the hub, and an elongate catheter tube designed for insertion into a blood vessel of a patient. The elongate catheter tube is coupled to the hub and includes at least one fluid-carrying lumen within the outer wall extending between a proximal end and a distal end of the elongate catheter tube. The fluid-carrying lumen is in fluid communication with the extension leg and an opening in the outer wall at the distal end of the elongate catheter tube. The elongate catheter tube also includes at least one terminating lumen within the outer wall extending to a closed termination point.

A split-tip catheter for placement within the vasculature of a patient and for use in hemodialysis or other suitable procedures, and methods of use. The split-tip catheter can include a catheter body defining a first lumen and a second lumen, and a split distal region extending from a distal end of the catheter body. The split distal region can include an arterial segment defined by an outer wall enclosing an arterial segment lumen, the arterial segment lumen in fluid communication with the catheter body first lumen, and a venous segment defined by an outer wall enclosing a venous segment lumen, the venous segment lumen in fluid communication with the catheter body second lumen, the venous segment outer wall extending from the catheter body distal end to a distal nose portion. The distal nose portion can taper from a first outer perimeter to a second smaller outer perimeter.

A treatment system includes a dual lumen catheter system. The first lumen is open to systemic circulation. The second lumen is open to a target delivery location. In an embodiment, a pressure-control element is provided that includes an expanded configuration adapted to constrain delivery through the second lumen to the target delivery location. Methods for treating tissues and organs via vascular pathways are provided.

Central catheters, central catheter assemblies, and methods thereof. A central catheter includes a catheter tube coupled with a number of the extension legs, a needle hub coupled with the catheter tube, where the needle hub is configured to receive a needle therethrough so that the needle is disposed within a primary catheter tube lumen. The central catheter includes a manifold hub for coupling the extension legs with the catheter tube. The manifold hub may be integral to the needle hub. The needle hub includes a septum within a needle hub lumen, where the septum is configured to define a fluid tight seal with a needle and to prevent fluid flow through the proximal portion of the needle-hub lumen when the needle is withdrawn from the needle-hub lumen. A method for introducing a central catheter into a blood vessel.