Atrial appendage occlusion systems and methods of using the same. In an exemplary embodiment of a system for occluding an atrial appendage of a heart, the system comprises a first device and a second device, wherein the first device comprises a first tube sized and shaped for insertion into the heart and a balloon coupled to the first tube, wherein the balloon is capable of inflation and deflation, wherein the second device comprises a second tube sized and shaped for insertion into a pericardial space surrounding the heart, the second tube comprising a lumen extending at least partially from a second tube distal end to a second tube proximal end and a loop sized and shaped to fit at least partially within the lumen of the second tube, wherein the loop is capable of protraction from the second tube distal end, and wherein the loop of the second device is configured for placement around the atrial appendage and to be secured around the atrial appendage.

Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.

The present invention relates to a medical interventional catheter, which includes a catheter body with both diagnostic and therapeutic capabilities. The catheter body includes a distal functional member configured for image-based monitoring of a tubular lumen of interest and for release of a therapeutic source to a target location in the tubular lumen of interest. The therapeutic source includes therapeutic energy and/or a therapeutic substance. This interventional catheter with both diagnostic and therapeutic capabilities provides real-time image-based monitoring in a therapeutic procedure, making the procedure more accurate and effective.

The present invention discloses a drug injection device for heart failure, and key technical solutions thereof are as follows: The device includes a delivery catheter and an abutting component disposed at one end of the delivery catheter. Multiple guide holes are formed in the abutting component. A reservoir tube is slidably connected in the delivery catheter. Multiple injection needles in communication with the reservoir tube are disposed at one end of the reservoir tube close to the abutting component. The multiple injection needles are slidably inserted in the multiple guide holes respectively in one-to-one correspondence. A sealing plate is rotatably connected in an inner wall of one end of the reservoir tube close to the injection needle. The present invention has the following technical effects: By providing the reservoir tube, the present invention enables adjustment of the movable tube's extension length from the injection tube during operation. This controls the distance between the injection piston and the sealing plate, where a space volume between the injection piston and the sealing plate is a total dosage of the single-dose medication. In this way, accurate dose control is achieved for each injection.