A delivery device for delivering an instrument through an intravenous catheter may include a housing, a rotary element disposed within the housing, and an instrument. In some embodiments, the rotary element may include a groove, which may extend around at least a portion of the circumference of the rotary element. In some embodiments, the instrument may be disposed within the groove and/or between the rotary element and the housing. In some embodiments, in response to rotation of the rotary element with respect to the housing, the instrument may be advanced distally through an port of the housing. In some embodiments, the instrument may include a guidewire, a probe, tubing, or a light tube.

An adductor canal block introducer for introducing a catheter and also administering an initial dose of local anesthetic. The adductor canal block introducer generally includes a cannula having an elongated body with a distal end, a proximal end, and a slot extending along the elongated body, the slot having two sides and a lower surface. It also includes a cannulated trocar positioned in the slot of the cannula, the cannulated trocar having a distal end and a proximal end, wherein the trocar includes a discharge proximate to the distal end, wherein an inlet and the discharge are in fluid communication with each other. The introducer also includes a catheter positioned in the slot, held in place by the cannulated trocar. The catheter may also be positioned by a grasper introducer that holds the catheter and also includes a discharge at its distal end through which an anesthetic can be administered.

A nerve block introducer for introducing a catheter and also administering an initial dose of local anesthetic, the introducer having an elongated body with a distal end and a proximal end, an inlet, and at least one discharge opening for the local anesthetic near the distal end. The introducer also includes a grasping member near the distal end of the elongated body, the grasping member operably coupled to a handle near the proximal end of the elongated body such that the grasping member can be used to releasably hold a catheter by operation of the handle. The catheter may thus be positioned and left in place following removal of the introducer.

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases.

An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

Systems, apparatuses and methods are provided for identifying the position of a catheter relative to internal tissue and controlling injection of a therapeutic substance(s) into the internal tissue. In one embodiment, a catheter includes one or more position sensing electrodes disposed at or near a distal end of the catheter that allow identifying the position of the catheter relative to the internal tissue. The catheter also includes one or more contact sensors that provide an indication of contact and/or contact forces between the catheter and internal tissue before and after a therapy delivery needle is extended from the catheter into the internal tissue. Outputs of the contact sensor(s) allows for confirming insertion of the therapy delivery needle into the internal tissue to a desired depth. Once inserted to the desired depth, a therapeutic substance may be injected into the internal tissue at the desired depth.

A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.

An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

Compositions and methods are described for the delivery of a fully human post-translationally modified (HuPTM) monoclonal antibody (mAb) or the antigen-binding fragment of a mAb against human vascular endothelial growth factor (hVEGF)such as, e.g., a fully human-glycosylated (HuGly) anti-hVEGF antigen-binding fragmentto the retina/vitreal humour in the eye(s) of human subjects diagnosed with ocular diseases caused by increased neovascularization, for example, neovascular age-related macular degeneration (nAMD), also known as wet age-related macular degeneration (WAMD), age-related macular degeneration (AMD), and diabetic retinopathy.

Systems and methods are provided for injecting one or more agents into tissue within a patient's body. In one embodiment, an injection device includes a substantially axially incompressible elongate member including a lumen extending between proximal and distal ends thereof. A distal stop is provided on the distal end and a needle tip extends distally beyond the distal stop, the needle tip having a cross-section smaller than the distal end. The needle tip includes a passage communicating between the lumen and an outlet in the distal tip that has having a cross-section smaller than the lumen. In an exemplary embodiment, the elongate member includes a coil extending between the proximal and distal ends, and a sleeve disposed within an interior region of the coil extending between the proximal and distal ends. The sleeve defines the lumen and may be free-floating within at least a portion of the coil.