The present invention relates to an endoscopic treatment instrument. The endoscopic treatment instrument of the present invention includes a dual tube inserted into a channel of an endoscope, the dual tube including an outer tube and an inner tube being inserted into the outer tube and moving forward and backward relative to the outer tube, wherein since the outer tube of the dual tube is made of a plastic material having a silicone compound added to an organic polymer, when the inner tube moves forward and backward along the channel relative to the outer tube while the dual tube is bent, frictional resistance between an outer circumferential surface of the inner tube and an inner circumferential surface of the outer tube, is lower than frictional resistance therebetween when the outer tube and the inner tube of the dual tube are all made of an organic polymer alone.

Devices and methods for assisting cardiac function. In an exemplary embodiment of a device for assisting heart function of the present disclosure, the device comprises a first plate and an opposing second plate, each plate having an inner surface, a cardiac processor coupled to at least one of the first plate and the second plate, a bladder having an inner chamber and disposed between the inner surfaces, and a first catheter having a proximal end in communication with the inner chamber of the bladder and a distal end having a first pericardial balloon coupled thereto, wherein a gas and/or a liquid within the inner chamber of the bladder can be injected into the first pericardial balloon upon compression of the first plate relative to the second plate, and wherein the gas and/or the liquid can be removed from the first pericardial balloon upon retraction of the first plate relative to the second plate.

In a transseptal crossing needle device for inserting an outer sheath through a septum, an inner dilator sheath is received within the outer sheath and a needle having a curved end portion adjacent a tip of a tip portion of the needle is provided, the needle being received in the inner dilator sheath. The needle tip portion comprises an angled transverse end surface terminating at said tip and slanting away from an inner concave curved wall of said inner sheath curved by the needle curved end portion, the needle tip being spaced not only away from said inner concave curved wall of said inner sheath but also away from an inner convex curved wall of said inner sheath opposite said concave wall to reduce or eliminate skiving of material from the concave and convex inner walls of the inner sheath.

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases.

A method for enhancing a surgical procedure includes providing a three-dimensional model of a patient's organ of a patient based on pre-operative image data of the patient's organ; identifying positional data corresponding to a first position of at least one target treatment anatomy of the patient relative to a second position of an ancillary target anatomy of the patient based on an analysis of the three-dimensional model of the patient's organ of the patient; selecting a puncture location based on the identified positional data; and displaying, by an augmented reality device, a virtual organ object via an augmented reality display system overlaying a real-world environment, the virtual organ object corresponding to the three-dimensional model and visually indicating the selected puncture location.

A therapeutic device, therapeutic system and therapeutic method for myocardium repair, wherein the therapeutic device comprises a treatment needle for piercing the heart to release a therapeutant. The treatment needle includes a needle body (5a), the interior of the needle body (5) has a therapeutant conveying cavity, an end of the needle body (5a) is a needle (5b) which can pierce the myocardium and guide the needle body (5a) to pass through the myocardium, and the needle (5b) has a therapeutant output port which is connected to the therapeutant conveying cavity. The therapeutic device enters into the myocardium in a minimally invasive manner to release the therapeutant to the vicinity of the lesion to improve myocardial function or activity and prevent further deterioration of the disease.

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases.

A medical puncture needle comprising includes: a rod-shaped body portion; and a blade surface formed at a distal end portion of the rod-shaped body portion. The blade surface includes: a first blade surface portion that is inclined with respect to a central axis of the body portion and extends to a tip, and a second blade surface portion that is formed on a back side of the first blade surface portion. A blade edge extending to the tip is formed by a ridgeline at which the first blade surface portion intersects the second blade surface portion. The second blade surface portion comprises a first plane and a second plane having different angles with respect to a virtual plane including the central axis passing through the tip at an orthogonal cross-section that is orthogonal to the central axis.

Methods of modifying the luminal profile of a body vessel are described. An example method comprises advancing a cannula out of the distal end of a catheter disposed within the lumen of a body vessel of an animal and toward a target site on the wall of the body vessel; passing contrast dye through the cannula toward the target site; simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of the body vessel at the target site; and passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site. Medical devices, medical device assemblies, and kits are also described.

A system for treating a patient comprises a delivery device and injectate. The delivery device comprises an elongate shaft with a distal portion and at least one delivery element positioned on the elongate shaft distal portion. The delivery device is constructed and arranged to deliver the injectate through the at least one delivery element and into tissue to create a therapeutic restriction in the gastrointestinal tract. Methods of creating a therapeutic restriction are also provided.