A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

A drug solution injection device includes: a catheter that has a hollow shaft, a hollow needle portion disposed on a distal end of the hollow shaft, and a lumen formed inside each of the hollow shaft and the needle portion and containing a drug solution; and a wire that is inserted into the lumen and is advanced from a proximal end of the lumen toward a distal end side so as to discharge the drug solution in the lumen from a distal end of the needle portion.

Intravascular devices and methods for intramural delivery of dissection fluids and infusates are disclosed herein. In some embodiments, the systems include an infusion assembly that can access a vessel wall at a depth within a layer of the vessel wall and advance a tissue manipulation component at approximately the same depth within the vessel wall to create an intramural space within the vessel layer. The infusion assembly can further deliver an infusate that includes a therapeutic drug or other agent into the intramural space.

An endoscopic treatment instrument including a dual tube inserted into a channel of an endoscope, the dual tube including an outer tube and an inner tube being inserted into the outer tube and moving forward and backward relative to the outer tube. The outer tube and the inner tube are made of a plastic material composed of a mixture of an organic polymer and a silicone compound, the organic polymer is polypropylene and the silicone compound is polydimethylsiloxane, and the polypropylene is 90 to 99.5 wt % and the polydimethylsiloxane is 0.5 to 10 wt %.

Tissue puncture devices, and systems and methods for accessing tissue (e.g., cardiovascular tissue) according to the present disclosure may include a tubular sheath extending along a longitudinal axis, the tubular sheath having a proximal end and a distal end, a needle disposed coaxially in the sheath, the needle having a proximal end and a distal end and being movable along the longitudinal axis of sheath, and a needle control mechanism disposed at the proximal end of the needle, the needle control mechanism being configured to lock the distal end of the needle in a first position retracted within the distal end of the sheath, and release the needle to an unlocked second position such that the distal end of the needle is extendable beyond the distal end of the sheath.

A medicine injection catheter includes: a catheter main body formed with a medicine supply lumen; a tubular body connected to the distal end of the catheter main body and having a lumen communicating with the medicine supply lumen; an injection needle connected to the tubular body; a tubular cover member that accommodates the tubular body and that is configured to be advanced and retracted in the axial direction of the catheter main body between a first position where a distal end of the injection needle is accommodated in the tubular cover and a second position where the distal end of the injection needle protrudes forward from the inside space; a closing member to close and open the lumen of the tubular body, a motion conversion mechanism which converts advancing/retracting motion of the cover member into movement of the closing member to close the lumen of the tubular body.

Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.

An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

The deflectable tip catheters can be used with a primary delivery system (e.g., a bronchoscope, endoscope, or other surgical access device) to access a certain target tissue, such as a tumor (e.g., a lung tumor). The primary access device provides initial access and the deflectable tip catheter can be passed through the primary access device to reach the target tissue which is not otherwise accessible by the primary access device. The deflectable tip catheters have an internal bore free of obstructions such that a drug delivery device (e.g., a needle) or a diagnostic tool can be passed therethrough to directly access the target tissue.

Devices for transferring fluid to or from a subject include an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen. The devices also include an elongate needle having opposing proximal and distal ends. The elongate needle is configured so that the distal end of the needle extends out of the distal end of the cannula a suitable adjustable distance. The devices also include a housing with a length adjustment mechanism that adjusts a length between the tip of the needle and the distal end of the tubular cannula.