A therapeutic device, therapeutic system and therapeutic method for myocardium repair, wherein the therapeutic device comprises a treatment needle for piercing the heart to release a therapeutant. The treatment needle includes a needle body (5a), the interior of the needle body (5) has a therapeutant conveying cavity, an end of the needle body (5a) is a needle (5b) which can pierce the myocardium and guide the needle body (5a) to pass through the myocardium, and the needle (5b) has a therapeutant output port which is connected to the therapeutant conveying cavity. The therapeutic device enters into the myocardium in a minimally invasive manner to release the therapeutant to the vicinity of the lesion to improve myocardial function or activity and prevent further deterioration of the disease.

Devices for transferring fluid to or from a subject include an extension tube assembly with an axially extending inner tube configured to couple to an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen and an axially extending inner tube. The inner tube extending through the tubular cannula defines an exposed needle tip and is in fluid communication with the inner tube of the extension tube assembly. The needle tip extends out of a distal end of the tubular cannula a suitable distance.

Disclosed embodiments relate to devices and related methods for delivering a composition to a subject. In some embodiments, a device may include a catheter coupled to a handle. The handle may include proximal and distal handle portions that are moveable relative to one another to selectively expose a needle at a distal end of the catheter. The proximal handle portion may include a container coupling and a grip extending proximally from the container coupling.

Devices and methods for assisting cardiac function. In an exemplary embodiment of a device for assisting heart function of the present disclosure, the device includes a first plate and an opposing second plate, each plate having an inner surface, a cardiac processor coupled to at least one of the first plate and the second plate, a bladder having an inner chamber and disposed between the inner surfaces, and a first catheter having a proximal end in communication with the inner chamber of the bladder and a distal end having a first pericardial balloon coupled thereto, wherein a gas and/or a liquid within the inner chamber of the bladder can be injected into the first pericardial balloon upon compression of the first plate relative to the second plate, and wherein the gas and/or the liquid can be removed from the first pericardial balloon upon retraction of the first plate relative to the second plate.

Needle assemblies and related methods are disclosed having a needle hub with a needle, a catheter tube with a catheter hub and having the needle extending through the catheter tube; and a valve positioned in an interior cavity of the catheter hub, the valve having a first section with a first chord, a second chord, and a plurality of slits defining a plurality of flaps, a second section attached to the first section, and a third section attached to the first section; an inside edge formed on the second section and pressed against the first section; an inside edge formed on the third section and pressed against the first section; and wherein a first flow path is provided adjacent the first chord and a second flow path is provided adjacent the second chord.

An insertion and retraction device is described for delivery and removal of a microparticle from target tissue. The device comprises a magnetic or magnetizable needle or cannula having a distal end, a proximal end and a lumen adapted to convey microparticles; a tubular catheter receiving the needle or cannula; a pressure device adapted for delivery of microparticles through the needle or cannula lumen by pressure; a magnetic field modulator adapted to move the needle or cannula by modulation of a magnetic field; and a magnetic sensor positioned toward the distal end of the tubular catheter responsive to a magnetic moment of the microparticle.

An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

A device may comprise a shaft comprising a hollow body, an anchor disposed adjacent an end of the shaft, wherein the anchor is configured to engage a surface to releasably secure the shaft to the surface, and a needle at least partially disposed within the shaft and is configured to be advanced toward the surface and outside of the shaft.

An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

A method of making a barbed microcatheter having fluid egress openings includes obtaining a barbed microcatheter blank having a hollow tube with a proximal end, a distal end, and an elongated lumen that extends between the proximal and distal ends of the hollow tube, and first and second flattened regions that extend along opposite sides of the hollow tube. The method includes removing material from the first and second flattened regions of the barbed microcatheter blank to form barbs projecting outwardly from the opposite sides of the hollow tube, and using cutting elements for forming fluid egress openings in a wall of the hollow tube that are in fluid communication with the elongated lumen of the hollow tube. The method includes forming a tissue anchor that is connected with the proximal end of the hollow tube, and securing a surgical needle with the distal end of the hollow tube.