Provided is a light delivery device for delivering light to a tissue of a patient comprising a microarray of tissue penetrating members, each tissue penetrating member having a distal end and a proximal end and configured to be inserted into the tissue, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member; a transparent substrate having a top surface and a bottom surface, wherein the bottom surface supports the tissue penetrating members; a plurality of optical sources supported by the top surface of the substrate and in optical communication with the microarray of tissue penetrating members; the plurality of optical sources is configured to operably emit light; and an encapsulation layer disposed over the microarray of tissue penetrating members.

Methods and kits for delivering pharmaceutical agents to the adventitia and other regions outside the external elastic lamina (EEL) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the EEL and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally and radially along the blood vessel. Confirmation that a delivery aperture of the needle lies beyond the EEL may be required before delivering the pharmaceutical agent. In one example, the catheters are used to deliver dexamethasone and other anti-inflammatory agents to the peripheral and other vasculature to treat peripheral vascular disease and other conditions.

A fluid delivery catheter that uses micro-needles for fluid delivery though a vessel wall. The catheter may provide fluid delivery therapy for various procedures, such as, for example, delivery of tumescent fluid or renal denervation. The catheter includes an elongate member with deployable and retractable needles disposed about a distal end of the elongate member. The needles may be disposed radially about the distal end and/or along a length of the distal end.

The present disclosure provides an inventive method of treating deteriorated skin tissue in the face or selected areas of the body, wherein the skin tissue has deteriorated due to aging and/or other factors, by injecting mesenchymal stem cells (MSCs) into these areas, resulting in improving and/or restoring the affected areas. In one aspect, the MSCs are obtained autogenously. In another aspect, the MSCs are minimally manipulated. In yet another aspect, treatment of the skin tissue is carried out using bone marrow concentrate that contains the MSCs. A platelet rich plasma (PRP) may be added to a bone marrow concentrate containing MSCs.

An exemplary neural electrode device as disclosed includes a storage in which fluid is stored; an electrode array which delivers the fluid to a subject, acquires bio-signals from the subject, or provides stimulus to the subject; an electronic circuit unit which allows the fluid to flow from the storage to the electrode array, processes the bio-signals acquired from the electrode array, or provides stimulus signals to the electrode array; and a connection portion which includes a cable extending from the storage to the electrode array and provided with a leading wire electrically connecting the electrode array to the electronic circuit unit, and a fluidic channel through which fluid flows between the storage and the electrode array.

Microarray applicator (10000) including a microarray carrier (8000), which is retained within a housing (2000) by virtue of microarray carrier (8100) being engaged withholder (2400). Microarray patch (8200) and flexible backing (8220) are positioned such that the central portion (8210) has microneedles (8211) protrude in the direction opposite from the bottom (7200) of plunger (7000). Plunger (7000) is in a first position, having first notch (7310) engaged with ridge (2320). After activation, wherein plunger (7000) is in a second position such that second notch (7320) is engaged with ridge (2320). Here, bottom (7200) of plunger (7000) extends below first major surface (2100) of housing (2000) and has ejected microarray patch (8200).

Microarray applicator comprising housing and plunger and method of using the same.

Proposed is a drug-eluting expandable urethral balloon catheter. The drug-eluting expandable urethral balloon catheter includes a tube part inserted into the urethra, a separation prevention part including a first balloon that expands in the bladder according to the inflow of fluid to prevent separation the of tube part and maintain airtightness of the bladder, a drug injection part having a plurality of pores formed so that a drug is injected into the stricture site of the urethra, a urethra expansion part including a second balloon which is positioned on a front end of the drug injection part and inflates or contracts according to the inflow and outflow of fluid, and a branched connection part branched from one side of the tube part to be connected thereto so as to enable fluid to flow in and out of the tube part.

Disclosed herein are drug delivery devices including catheter assemblies, infusion systems, pre-filled syringes, methods of use, combination products, kits of parts, and drug products with parts lists for independent sourcing, for use in the otic administration of a drug product to a subject in need thereof.