A blood pump is disclosed. The blood pump apparatus is arranged to provide pulsatile flow, and comprises a flexible inner cylindrical duct providing a blood flow region, and an outer cylindrical duct arranged to surround the inner cylindrical duct and arranged to accommodate a pumping fluid. In the pump the inner cylindrical duct is described as comprising a blood inlet for receiving blood into the region, a blood outlet for passing blood out from the blood flow region and a passageway therebetween. There is also described the feature of the inner duct comprising a non return valve at the blood inlet and a non return valve at the blood outlet, the outer cylindrical duct having a fluid port for a pumping fluid, and a pump device arranged to cyclically deliver and withdraw pumping fluid to the fluid port thereby cyclically compressing and expanding the flexible inner cylindrical duct urging blood through the blood flow region and delivering a pulsating blood flow through the blood outlet.

A breath actuated metered dose inhaler may comprise a canister fire system configured to fire a medicament containing canister in response to patient inhalation. The canister fire system may comprise a pneumatic force holding unit and having a rest configuration in which a metering valve of the canister is in a refill configuration; a prepared configuration in which a canister actuation force is retained by the pneumatic force holding unit and the canister fire system is actuatable by patient inhalation induced airflow; and a fire configuration in which the metering valve is in a dose delivery position. When in the prepared configuration, the force retained by the pneumatic force holding unit may be reduced by less than about 6% over a period of 5 minutes, preferably less than about 3% over a period of 5 minutes.

An injection system includes an injection system body defining a proximal opening at a proximal end thereof and a distal needle interface at a distal end thereof. The system also includes proximal and distal stopper members disposed in the injection system body, forming a proximal drug and a distal drug chamber. The system further includes a plunger member configured to insert the proximal stopper member relative to the injection system body. Moreover, the system includes a valve forming an openable barrier between the distal needle interface and the distal drug chamber. The valve includes an outer member including a distal diaphragm, and an inner member. The distal diaphragm is configured to elastically deform distally away from the inner member with increased pressure in the distal drug chamber to allow flow from the distal drug chamber to the distal needle interface.

A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.

A breath actuated metered dose inhaler may comprise a canister fire system configured to fire a medicament containing canister in response to patient inhalation. The canister fire system may comprise a pneumatic force holding unit and having a rest configuration in which a metering valve of the canister is in a refill configuration; a prepared configuration in which a canister actuation force is retained by the pneumatic force holding unit and the canister fire system is actuatable by patient inhalation induced airflow; and a fire configuration in which the metering valve is in a dose delivery position. When in the prepared configuration, the force retained by the pneumatic force holding unit may be reduced by less than about 6% over a period of 5 minutes, preferably less than about 3% over a period of 5 minutes.

A tubing assembly for use with a fluid delivery system has a first fluid line having a distal end and a proximal end for connecting to a first fluid source, and a second fluid line having a distal end and a proximal end for connecting to a second fluid source. The tubing assembly further has a third fluid line having a distal end and a proximal end, and a connector assembly for connecting the distal end of the first fluid line and the distal end of the second fluid line to the proximal end of the third fluid line. A tubing holder receives at least a portion of the third fluid line. The tubing holder has a first portion and a second portion movable relative to the first portion to selectively block fluid flow through the third fluid line.

A medical connector can include a body having a fluid path with an inlet port, an outlet port, a luer portion, and a post extending through a fluid path. An arm having a latch member is coupled to the body to engage a ridge or thread on an exterior surface of a reciprocal connector. The arm may also include an extension. When the connector is in an open position, the latch member restricts retraction of the reciprocal connector from the outlet port. A seal is coupled to the body and includes a flap extending across the outlet port or a bellows to compress along an axis. In a closed position, the post restricts flow through the luer portion. In an open position, the post permits flow through the luer portion.

A membrane valve for controlling flow and pressure relief has a format following the anatomy and the action mechanism of a sphincter, in order not to have restriction points to the fluid flow. The valve includes a body provided with terminal sections provided with ends and, internally, a folded membrane which opens and closes according to the flow and/or pressure exerted therein, directly or indirectly, locally or remotely.

Disclosed is a conduit that is adapted to be positioned in the myocardium to provide a passage for blood to flow from a heart chamber to a coronary artery. The conduit has a sphincter to open or close the passage in response to an electric current applied from a control unit and a one-way valve positioned therein to prevent the backflow of blood from the coronary artery into the heart chamber. Also disclosed is an implantable system or device comprising the conduit, a sensor unit to measure at least one physiological condition and a control unit to analyze signals form the sensor unit and open the sphincter for improving coronary blood flow in order to increase myocardial oxygen delivery during periods of high myocardial demand.

A mounting element defining a bore, the mounting element being configured to mount to an exterior surface of an organ of a patient. A one way valve sized to be received and retained within the bore of the mounting element is included, the one way valve having an open position and a closed position. The one way valve substantially occludes the bore when the valve is in the closed position. The one way valve is biased in the closed position. A plug having a lumen extending there through is included, the plug being configured to be releasably inserted through at least a portion of the one way valve. The plug is configured to transition the one way valve from the closed position to the open position and to maintain the one way valve in the open position when the plug is inserted within the bore.