A pumping device includes a single-use device and a reusable device. The single-use device is to be inserted into the reusable device and includes two pump units in series, one behind the other. Each pump unit includes a rotor for a bearingless motor, and can be magnetically levitated and driven without contact for rotation about an axial direction. The reusable device includes a stator for each rotor which form an electromagnetic rotary drive for rotating the rotor about the axial direction. Each stator is a bearing and drive stator with which the rotor can be magnetically driven and levitated without contact with respect to the stator. An independent control device is provided for each stator, and can independently activate a respective stator.

An exemplary apparatus, can include, for example, a circulating tumor cell (CTC) treatment arrangement, a pump arrangement configured to circulate a fluid through the CTC treatment arrangement, and an electric field generator electrically connected to the CTC treatment arrangement, and configured to apply an electric field to the fluid circulating through the CTC treatment arrangement. The pump arrangement can be a peristaltic pump, which can be configured to continuously circulate the fluid through the CTC treatment arrangement. According to another exemplary embodiment of the present disclosure, method, system and computer-accessible medium can be provided for killing at least one circulating tumor cell (CTC). Using such exemplary embodiment, blood can be pumped from a body of a patient to an electroporation chamber inside of a CTC treatment arrangement. An electric field can be applied to the blood located in the electroporation chamber in order to kill the CTC. The electric field-applied blood can be pumped back into the body.

An exemplary apparatus, can include, for example, a circulating tumor cell (CTC) treatment arrangement, a pump arrangement configured to circulate a fluid through the CTC treatment arrangement, and an electric field generator electrically connected to the CTC treatment arrangement, and configured to apply an electric field to the fluid circulating through the CTC treatment arrangement. The pump arrangement can be a peristaltic pump, which can be configured to continuously circulate the fluid through the CTC treatment arrangement. According to another exemplary embodiment of the present disclosure, method, system and computer-accessible medium can be provided for killing at least one circulating tumor cell (CTC). Using such exemplary embodiment, blood can be pumped from a body of a patient to an electroporation chamber inside of a CTC treatment arrangement. An electric field can be applied to the blood located in the electroporation chamber in order to kill the CTC. The electric field-applied blood can be pumped back into the body.

A method is provided for the real time calibration of a pump that is part of a reusable hardware component having a programmable controller during a blood separation procedure where fluid is flowed through a tubing in a tubing set by action of the pump. The method comprises programming the controller with a continuous function defining a relationship between pump inlet pressure and pump stroke volume; commencing the fluid processing procedure to operate the pump to draw fluid through the tubing; measuring fluid pressure in the tubing at the inlet of the pump; calculating a current pump stroke volume with the controller based on the continuous function and the pump rotational rate; and adjusting the pump rotational rate utilized by the controller to control the procedure to achieve a target fluid flow rate. The continuous function defining the relationship between pump inlet pressure and the pump stroke volume may be empirically determined over a predetermined range of inlet pressures.

A pump device (10) includes a housing (30) including a blood inflow port (38) through which blood flows in, and having a fixed-side repulsive magnet (44) disposed in an annular manner; and an impeller (14) that is rotatably housed inside the housing (30), and having a movable-side repulsive magnet (56) disposed in an annular manner. The fixed-side repulsive magnet (44) is disposed in a position offset toward the blood inflow port (38) side relative to the movable-side repulsive magnet (56). In the fixed-side repulsive magnet (44) and the movable-side repulsive magnet (56), a fixed-side repulsive surface (44a) and a movable-side repulsive surface (56a) adjacent to each other have the same polarity.

The invention relates to an apparatus for exchanging material between blood and a gas/gas mixture, comprising a chamber (1) through which blood can flow and in which a plurality of material-permeable fiber tubes is provided, the gas/gas mixture being flowable through the fiber tubes, blood being flowable around the fiber tubes. At least one deformable element (9) is provided in the chamber (1) in addition to the fiber tubes, through which the gas/gas mixture can flow, this deformable element being deformable and restorable, in particular compressible out of a relaxed shape and restorable to a relaxed shape by pressure fluctuations acting on the at least one element (9) externally, in particular pressure fluctuations transmitted by the blood in the chamber (1).

Extracorporeal circuit devices can be used for on-pump open-heart surgery to support surgical procedures such as coronary artery bypass grafting. In some cases, a centrifugal pump is used as part of an extracorporeal circuit. Centrifugal pump heads are described herein that induce flow on two sides of an impeller plate, and that can be conveniently mechanically assembled.

Extracorporeal circuit devices can be used for on-pump open-heart surgery to support surgical procedures such as coronary artery bypass grafting. In some cases, a centrifugal pump is used as part of an extracorporeal circuit. Centrifugal pump heads are described herein that induce flow on two sides of an impeller plate, and that can be conveniently mechanically assembled.

A device and method are provided for monitoring access to a patient by a device that withdraws liquid from the patient and/or supplies liquid to the patient, via a flexible line. A vessel access can be monitored during an extracorporeal blood treatment for which the blood of a patient is withdrawn via a flexible arterial line having an arterial puncture cannula, and supplied to the patient via a flexible venous line having a venous puncture cannula. The monitoring device has a line guide for loosely guiding a line segment of the flexible line. By detecting a change in situation of the loosely guided line segment, a conclusion is made as to whether an incorrect vessel access has occurred.

A device and method are provided for monitoring access to a patient by a device that withdraws liquid from the patient and/or supplies liquid to the patient, via a flexible line. A vessel access can be monitored during an extracorporeal blood treatment for which the blood of a patient is withdrawn via a flexible arterial line having an arterial puncture cannula, and supplied to the patient via a flexible venous line having a venous puncture cannula. The monitoring device has a line guide for loosely guiding a line segment of the flexible line. By detecting a change in situation of the loosely guided line segment, a conclusion is made as to whether an incorrect vessel access has occurred.