A blood pump-oxygenator system comprises at least one blood pump, an oxygenator, inflow and outflow cannulas, connected to form a closed series circuit operable as a cardiopulmonary bypass system for extracorporeal processing of the patient's blood. The blood pump conveys blood through the circuit from the patient into the inflow cannula, through the oxygenator and out of the outflow cannula back into the patient. A manifold is connected between the inflow and outflow cannulas so blood passes through the manifold, wherein the manifold accommodates the blood pump and the oxygenator to form a recirculation loop configured to recirculate at least part of the blood in the circuit so the blood passes over the oxygenator multiple times. An extra blood pump is positioned at the outflow cannula to deliver a set volume to the patient, controllable independently from the blood pump that circulates the blood in the manifold including the oxygenator.

A blood pump-oxygenator system comprises at least one blood pump, an oxygenator, inflow and outflow cannulas, connected to form a closed series circuit operable as a cardiopulmonary bypass system for extracorporeal processing of the patient's blood. The blood pump conveys blood through the circuit from the patient into the inflow cannula, through the oxygenator and out of the outflow cannula back into the patient. A manifold is connected between the inflow and outflow cannulas so blood passes through the manifold, wherein the manifold accommodates the blood pump and the oxygenator to form a recirculation loop configured to recirculate at least part of the blood in the circuit so the blood passes over the oxygenator multiple times. An extra blood pump is positioned at the outflow cannula to deliver a set volume to the patient, controllable independently from the blood pump that circulates the blood in the manifold including the oxygenator.

Intravascular inflatable medical devices and their methods of manufacture and use. The inflatable medical devices may include a conduit that includes an inflatable wall, with the inflatable wall defining a lumen therein. The inflatable wall may include an outer layer and an inner layer, and optionally an intermediate layer between the inner and layers. Intermediate layers may include one or more couplings between the outer and inner layers, and may include radial connectors extending between the outer layer and the inner layer.

A percutaneous circulatory support device includes a housing and an impeller disposed within the housing. The impeller is rotatable relative to the housing to cause blood to flow through the housing. A cannula is coupled to the housing, and a distal tip portion is coupled to the cannula opposite the housing. The distal tip portion includes an inner shaping core configured to maintain a predetermined shape of the distal tip portion and an outer layer disposed outwardly from the inner shaping core or the distal tip portion includes an atraumatic, sphere-shaped distal end.

A rotor for a pump has a housing and a rotor, and has at least one blade. The rotor is able to be actuated to rotate about an axis of rotation in order to convey a fluid in the axial or radial direction, and the rotor is able to be deformed in the radial direction between a first, radially compressed state and a second, radially expanded state. At a maximum speed of rotation of the rotor at which the power of the pump is at a maximum, the blade is essentially radially oriented, and/or the rotor has its maximum diameter.

A rotor for a pump has a housing and a rotor, and has at least one blade. The rotor is able to be actuated to rotate about an axis of rotation in order to convey a fluid in the axial or radial direction, and the rotor is able to be deformed in the radial direction between a first, radially compressed state and a second, radially expanded state. At a maximum speed of rotation of the rotor at which the power of the pump is at a maximum, the blade is essentially radially oriented, and/or the rotor has its maximum diameter.

In a pump housing having an interior for accommodating a pump rotor, which may be transferred from a radially compressed state into a radially expanded state, and comprises a housing skin revolving in circumferential direction, as well as at least one reinforcement element, a stretch-resistant element revolving in circumferential direction is provided, which is stretched less than 5% in the expanded state as opposed to the force-free state in circumferential direction, and which limits any further expansion of the pump housing in radial direction.

In a pump housing having an interior for accommodating a pump rotor, which may be transferred from a radially compressed state into a radially expanded state, and comprises a housing skin revolving in circumferential direction, as well as at least one reinforcement element, a stretch-resistant element revolving in circumferential direction is provided, which is stretched less than 5% in the expanded state as opposed to the force-free state in circumferential direction, and which limits any further expansion of the pump housing in radial direction.

Disclosed are systems, devices, and methods that employ a pump to assist or support blood flow. An apparatus for pumping blood may include a pump housing having an outer wall disposed about a longitudinal pump axis, and having an upstream end and a downstream end; a blood flow straightener having a plurality of fins and positioned in the upstream end of the pump housing and secured to the pump housing by the plurality of fins; a diffuser having a plurality of diffuser fins and positioned in the downstream end of the pump housing and secured to the pump housing by the plurality of diffuser fins; and an impeller positioned between the blood flow straightener and the diffuser, and including a plurality of impeller blades. The apparatus may further include a pump drive configured to impart a rotational motion to the impeller by applying a magnetic field.

Apparatus and methods are described for manufacturing a housing for an impeller of a blood pump. A mandrel is placed inside an inner lining, with a central cylindrical portion of a frame disposed around the inner lining, the mandrel being shorter than a length of the inner lining. A portion of an elongate tube is placed around at least a portion of the frame. The inner lining, the frame and the portion of the elongate tube are heated, via the mandrel, and, while heating the inner lining, the frame, and the portion of the elongate tube, pressure is applied from outside the portion of the elongate tube, such as to cause the portion of the elongate tube to become coupled to the frame. Other applications are also described.