A positive displacement pump that triggers with the beating of a mammalian heart, through the monitoring of an ECG signal is disclosed. A programmable delay from the detection of the forthcoming contraction of the heart enables the pump to syncopate the ejection of the fluid with the events occurring in the cardiovascular system. This delayed ejection could be used to overlay the ejected fluid from the pump with a pressure wave in the artery of systemic circulation through a catheter connection between the pump and a physiological model (e.g., cow, dog, human). The outcome of this use could be to raise the pulse pressure in the system to take advantage of physiological pathways that respond to this transient change in blood pressure. The novelty of this system stems from the adaptable control architecture designed to augment the pulsatile characteristics of the cardiovascular system. This inventive concept could be expanded to encompass the augmentation (dampen or enhance) of pulsatile characteristics in any oscillating flow system.

A positive displacement pump that triggers with the beating of a mammalian heart, through the monitoring of an ECG signal is disclosed. A programmable delay from the detection of the forthcoming contraction of the heart enables the pump to syncopate the ejection of the fluid with the events occurring in the cardiovascular system. This delayed ejection could be used to overlay the ejected fluid from the pump with a pressure wave in the artery of systemic circulation through a catheter connection between the pump and a physiological model (e.g., cow, dog, human). The outcome of this use could be to raise the pulse pressure in the system to take advantage of physiological pathways that respond to this transient change in blood pressure. The novelty of this system stems from the adaptable control architecture designed to augment the pulsatile characteristics of the cardiovascular system. This inventive concept could be expanded to encompass the augmentation (dampen or enhance) of pulsatile characteristics in any oscillating flow system.

A pump system is provided for pumping a fluid and a method is provided for operating the pump system. The pump system comprises a first diaphragm fluid pump, a first inlet cannula connected to the first diaphragm fluid pump for supplying a fluid to the first diaphragm fluid pump, a first outlet cannula connected to the first diaphragm fluid pump for discharging the fluid out of the first diaphragm fluid pump, and a first service pump, which is connected via a first pressure line to the first diaphragm fluid pump and is confirmed to drive the first diaphragm fluid pump via the first pressure line. The pump system further comprises a first inlet flow sensor for detecting a first inlet flow of the fluid in the first inlet cannula and/or a first outlet flow sensor for detecting a first outlet flow of the fluid in the first outlet cannula.

A pump system is provided for pumping a fluid and a method is provided for operating the pump system. The pump system comprises a first diaphragm fluid pump, a first inlet cannula connected to the first diaphragm fluid pump for supplying a fluid to the first diaphragm fluid pump, a first outlet cannula connected to the first diaphragm fluid pump for discharging the fluid out of the first diaphragm fluid pump, and a first service pump, which is connected via a first pressure line to the first diaphragm fluid pump and is confirmed to drive the first diaphragm fluid pump via the first pressure line. The pump system further comprises a first inlet flow sensor for detecting a first inlet flow of the fluid in the first inlet cannula and/or a first outlet flow sensor for detecting a first outlet flow of the fluid in the first outlet cannula.

A device may include a frame including an inflow end and an outflow end. The frame defines a lumen between the inflow end and the outflow end. A device may include a first expandable member coupled to at least one portion of an internal surface of the frame and including a first inflation port. The first expandable member defines a first volume configured to receive an inflation fluid therein through the first inflation port. The first expandable member is configured to be reversibly inflatable to a first plurality of inflation states to partially or fully occlude the lumen. The devices described herein may be used to alleviate symptoms from congestive heart failure or chronic kidney disease.

A device may include a frame including an inflow end and an outflow end. The frame defines a lumen between the inflow end and the outflow end. A device may include a first expandable member coupled to at least one portion of an internal surface of the frame and including a first inflation port. The first expandable member defines a first volume configured to receive an inflation fluid therein through the first inflation port. The first expandable member is configured to be reversibly inflatable to a first plurality of inflation states to partially or fully occlude the lumen. The devices described herein may be used to alleviate symptoms from congestive heart failure or chronic kidney disease.

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusion line (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusion line (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

A device for the temporary circulatory assistance or back-up of the heart of a patient including: a linear actuator configured to move a membrane in a chamber so as to cause a pulsating fluid flow adapted to support the activity of the heart of the patient, which flow is characterised by a succession of phases of aspiration and phases of ejection of the fluid, a control unit configured to pilot the actuator and control the movement of the membrane, which piloting is carried out while taking into account input data originating from an ECG signal of the patient, the control unit is configured to determine a time offset between the instant at which the QRS complex of the ECG signal is detected and the instant at which an ejection phase is initiated.

A device for the temporary circulatory assistance or back-up of the heart of a patient including: a linear actuator configured to move a membrane in a chamber so as to cause a pulsating fluid flow adapted to support the activity of the heart of the patient, which flow is characterised by a succession of phases of aspiration and phases of ejection of the fluid, a control unit configured to pilot the actuator and control the movement of the membrane, which piloting is carried out while taking into account input data originating from an ECG signal of the patient, the control unit is configured to determine a time offset between the instant at which the QRS complex of the ECG signal is detected and the instant at which an ejection phase is initiated.