A tube manufacturing system is provided that is capable of manufacturing tube structures that are on the nanoscale and larger. The system provides for control as to the structure and atomic makeup of the feed sheet material used and provides motive force to the sheet material being used to continuously advance the sheet material through the various system components. After the tube structures are formed, they may be used in providing a source material for manufacturing macroscopic objects thus increasing the level of performance and capabilities of such objects due to the engineered properties of the tube structures formed within this system and method of manufacturing. Processes for manufacturing of nanotubes are also disclosed, as are nanotubes manufactured by the processes and system of the invention.

The present invention provides a peripheral nerve growth conduit for peripheral nerve repair, in particular conduits through which peripheral nerves can grow. The conduit includes poly--caprolactone (PCL). Preferably, the inner (luminal) surface of the conduit comprises pits having a depth of 1-4m. Suitably, the conduit may also include poly-lactic acid (PLA). The inner surface of the conduit may have been treated with an alkaline composition. The present invention also provides a method for treating a peripheral nerve damage using a peripheral nerve growth conduit including poly--caprolactone (PCL). The present invention also provides a kit for treating a peripheral nerve damage having a peripheral nerve growth conduit including poly--caprolactone (PCL).

Implementations described herein include films with maintained or decreased light transmittance despite a reduction in gauge. In particular, one or more implementations include a multi-layer film with each layer having differing opacity agents. The combination of the two different opacity agents in two different layers can have a synergistic effect that provide decreased light transmittance. Indeed, in one or more embodiments a multi-layer film with differing opacity agents in each layer has a decreased light transmittance despite a reduction in gauge and opacity agents.

Graphene reinforced materials and related methods of manufacture are provided. The graphene reinforced materials include graphene sheet or scroll, graphene-polymer sheet or scroll, and graphene-carbon sheet or scroll, each having material properties that are attractive across a broad range of applications and industries. The graphene reinforced materials generally include monolayer or multilayer graphene that is synthesized by annealing a catalyst substrate within a CVD chamber, introducing a hydrocarbon gas as a carbon source with the CVD chamber to form a layer of graphene on the catalyst substrate, detaching the catalyst substrate from the layer of graphene, and rolling the layer of graphene onto itself to form a scroll, optionally with the addition of a polymer layer or carbonized layer on the graphene layer.

Implementations described herein include films with maintained or decreased light transmittance despite a reduction in gauge. In particular, one or more implementations include a multi-layer film with each layer having differing opacity agents. The combination of the two different opacity agents in two different layers can have a synergistic effect that provide decreased light transmittance. Indeed, in one or more embodiments a multi-layer film with differing opacity agents in each layer has a decreased light transmittance despite a reduction in gauge and opacity agents.

The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.

Graphene reinforced materials and related methods of manufacture are provided. The graphene reinforced materials include graphene sheet or scroll, graphene-polymer sheet or scroll, and graphene-carbon sheet or scroll, each having material properties that are attractive across a broad range of applications and industries. The graphene reinforced materials generally include monolayer or multilayer graphene that is synthesized by annealing a catalyst substrate within a CVD chamber, introducing a hydrocarbon gas as a carbon source with the CVD chamber to form a layer of graphene on the catalyst substrate, detaching the catalyst substrate from the layer of graphene, and rolling the layer of graphene onto itself to form a scroll, optionally with the addition of a polymer layer or carbonized layer on the graphene layer.

The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.

A catheter with a film composite structure. The catheter at least includes a polymer film that is shaped such that a first polymer film layer, which is arranged inwardly relative to the catheter, and a second polymer film layer, which is arranged outwardly relative to the catheter, are produced; one or more electrodes arranged at least partially on an outer surface of the film composite structure; and a conductor structure, which includes conductive tracks for the electrical connection of the electrodes and which is arranged at least in part between the first and second polymer film layers. An associated production method for the catheter is also contemplated herein.

A method of forming a centralizer where a flat plate is created into a tubular where the flat plate is typically rolled so that two sides of the plate contact one another and are then linked, typically by welding. Openings are then created in the tubular such that there are no corners or other points that stress cracks may originate. Once the openings are created the remaining material between adjacent openings forms ribs. The openings created in the tubular are generally aligned with the long axis of the tubular. The material at the upper and lower end of the flat plate where openings were not created serve as circumferential collars. The ribs may be radially outwardly expanded in order to provide adequate stand-off. In many instances the ribs will also be hardened by heat treating or other hardening processes.