The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool. Providing cardiac parameters in real-time, along with warnings about adverse effects and recommendations to support cardiac function, such as increasing or decreasing the volumetric flow rate of blood pumped by the device, administering pharmaceutical therapies, and/or repositioning the blood pump allow clinicians to better support and treat cardiovascular disease.

A blood pump system includes a catheter, a pump housing disposed distal of a distal end of the catheter, a rotor positioned at least partially in the pump housing, a controller, and an electrode coupled a distal region of the blood pump. The electrode can be used to sense electrocardiogram (EKG) signals and transmit the signals to a controller of the blood pump. The operation of the blood pump can be adjusted based on the EKG signal and on cardiac parameters derived from the EKG signal. Further, the controller can determine a need for defibrillation or pacing of the patient's heart based on the signal and can administer treatment with electrical shocks to the heart via the electrode coupled to the blood pump. The use of an electrode with a blood pump already in place in the heart allows for more efficient and safer treatment of serious cardiac conditions.

A blood pump system includes a catheter, a pump housing disposed distal of a distal end of the catheter, a rotor positioned at least partially in the pump housing, a controller, and an electrode coupled a distal region of the blood pump. The electrode can be used to sense electrocardiogram (EKG) signals and transmit the signals to a controller of the blood pump. The operation of the blood pump can be adjusted based on the EKG signal and on cardiac parameters derived from the EKG signal. Further, the controller can determine a need for defibrillation or pacing of the patient's heart based on the signal and can administer treatment with electrical shocks to the heart via the electrode coupled to the blood pump. The use of an electrode with a blood pump already in place in the heart allows for more efficient and safer treatment of serious cardiac conditions.

The invention relates to a pressure sensor (100) comprising: a biocompatible housing (110), a biocompatible flexible membrane (120) covering an open portion in the housing (110), a pressure transferring medium, an attachment portion (130), an electrical connection (140), and a pressure sensitive sensor (150).

A system that includes a cannula and a flexible hypotube attached to the cannula configured to slidably receive an optical fiber. The system may be configured to have a ratio R1 of a diameter of the outer surface of the hypotube to a diameter of the inner surface of the cannula is 1:5>R1>1:25, and/or where the flexible hypotube comprises a tubular portion containing at least one cut extending from the outer surface at least partially through the sidewall of the flexible hypotube, each cut having a maximum width of between 0.01 and 0.1 mm.

A system that includes a cannula and a flexible hypotube attached to the cannula configured to slidably receive an optical fiber. The system may be configured to have a ratio R1 of a diameter of the outer surface of the hypotube to a diameter of the inner surface of the cannula is 1:5>R1>1:25, and/or where the flexible hypotube comprises a tubular portion containing at least one cut extending from the outer surface at least partially through the sidewall of the flexible hypotube, each cut having a maximum width of between 0.01 and 0.1 mm.

Neuromodulation is used to enhance left ventricular relaxation and/or left ventricular contractility, during contemporaneous use of a mechanical circulatory support device to increase cardiac output or aid in unloading the heart. An exemplary neuromodulation system includes a therapy element positionable in proximity to at least one nerve fiber, and a stimulator configured to energize the therapy element to delivery therapy to the at least one nerve fiber such that left ventricular relaxation and left ventricular contractility are contemporaneously enhanced.

Neuromodulation is used to enhance left ventricular relaxation and/or left ventricular contractility, during contemporaneous use of a mechanical circulatory support device to increase cardiac output or aid in unloading the heart. An exemplary neuromodulation system includes a therapy element positionable in proximity to at least one nerve fiber, and a stimulator configured to energize the therapy element to delivery therapy to the at least one nerve fiber such that left ventricular relaxation and left ventricular contractility are contemporaneously enhanced.

Temporary vascular occlusion devices and methods for use thereof are described which provide temporary vascular occlusion while maintaining distal perfusion. The temporary vascular occlusion device may include a multiple layer scaffold covering having proximal and distal attachment zones separated by an unattached scaffold covering zone where the scaffold covering is adjacent to but not attached directly to the scaffold frame.

The present disclosure pertains to control units for non-occlusive blood pumps of an extracorporeal circulatory support as well as systems comprising such a control unit and corresponding methods. Accordingly, a control unit for a non-occlusive blood pump of an extracorporeal circulatory support is configured to receive a flow value of the extracorporeal circulatory support, to receive a measurement of an arterial pressure and an ECG signal of a supported patient over a predetermined period of time, to determine a mean arterial pressure of the extracorporeal circulatory support or of the supported patient from the measurement of the arterial pressure and an energy equivalent pressure from the flow value and the arterial pressure.