A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that the first internal pressure becomes equal to the second internal pressure in a state in which operation of a collection and returning pump (100) is stopped during at least one of a collection operation and a returning operation of a first cycle.

A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that, during a blood returning operation, the first internal pressure calculated by the first internal pressure calculation unit (110) becomes equal to the second internal pressure calculated by the second internal pressure calculation unit (112).

Systems and methods for preparing enriched biological samples, and methods of use thereof are described herein. The systems can include a containment device connected to a first insert to collect tissue fragments in the containment device or to a second insert to incubate tissue fragments with a blood sample in the containment device. The methods can include methods for preparing a cytokine or growth factor-enriched biological sample, such as IL-1 Ra-enriched serum, methods of treating inflammation, inflammatory joint, or rheumatoid arthritis, and methods of preventing inflammation of a joint following arthroscopic surgery.

A tray for processing platelet rich fibrin includes a base having at least one alignment structure, a screen attachment having at least one alignment structure for engagement with the base, and a lid having at least one alignment structure for engagement with the base and the screen attachment. The screen attachment includes a screen offset between the top and bottom surface of the screen. When the screen attachment is placed on the base with the top surface facing upward, the lid is configured to compress a fibrin clot placed on the screen to a first thickness, and when the screen attachment is placed on the base with the bottom surface facing upward the lid is configured to compress a fibrin clot placed on the screen to a second thickness different from the first thickness.

Device for the recovery of cell-free serum from whole blood, comprising a blood bag for the reception and the coagulation of the whole blood into a solid fraction and into a fluid containing a serum, wherein the blood bag has an outlet and a barrier in the area of the outlet which is suitable for retaining at least a major portion of the solid fraction and for the passage of said fluid, a filter module which is fluidically connected to the blood bag via the outlet, comprising an interior in which a semi-permeable membrane is arranged which subdivides the interior into a retentate space and a permeate space and allows the separation of the fluid into a serum as a permeate and into a retentate in which possible particulate components contained in the fluid remain, wherein the filter module has an inlet device for introducing the fluid into the retentate space and a permeate outlet for discharging the serum from the permeate space, and at least one receiving container for serum, comprising an inlet opening which is connected to the permeate outlet of the filter module via a connecting line.

Method for the recovery of cell-free serum from whole blood, wherein the method can be carried out by means of the described device.

A system for wound treatment using a serum, comprising a device for recovering serum from whole blood, comprising: a blood bag for the reception and coagulation of whole blood, which has an outlet for discharging the serum-containing fluid from the blood bag and a barrier in the region of the outlet for retaining the coagulum, a filter module which is fluidically connected to the blood bag and comprises a housing and an interior, in which a semi-permeable membrane is arranged, said membrane dividing the interior into a retentate space and a permeate space and separating the fluid discharged from the blood bag into a permeate comprising the serum and into a retentate in which any particulate components contained in the fluid remain.

The system for wound treatment further comprises a wound care system with a capillary membrane system for dispensing the serum to a wound. The capillary membrane system is connected to at least one supply line, which for its part is connected to the permeate outlet of the filter module.

A system for separating and transferring phases of a fluid through centrifugation including a centrifuge having a rotating axis, a platform that is rotatable around the rotating axis; and a device for separating and transferring the phases of the fluid. The device includes a separating container and a receiving container connected to the separating container through a connecting channel. A passive valve system is provided in the connecting channel. The device is mounted in the centrifuge platform such that in use at a first predefined range of centrifugal force a fluid provided within the separating container is separated into phases and at a second predefined range of centrifugal force the valve system opens, thereby transferring a phase of the fluid from the separating container to the receiving container.

Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 to 40,000 with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 to 40,000 with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

The present disclosure relates to a drug-device combination comprising a liquid solution (26) containing a biologic; and a nebulizer (10) for aerosolization of the liquid solution (26), the nebulizer (10) comprising a reservoir (24) for holding the liquid solution (26), the reservoir (24) having a vent (48) for maintaining atmospheric pressure in the reservoir (24), a vibratable membrane (60) having an active area (62) with apertures (110), wherein the liquid solution (26) is feedable to the active area (62) at a liquid side (64) of the membrane (60), a piezoelectric actuator for vibrating the membrane (60), whereby an aerosol of the liquid solution (26) is generated at the active area (62) at an aerosol side (66) of the membrane (60), the aerosol side (66) of the membrane (60) being opposite to the liquid side (64) of the membrane (60) and a plenum chamber (23) having an inlet (76) at an inlet side at the aerosol side (66) of the membrane (60) and an outlet (94) at an outlet side for administering the aerosol, the outlet (94) of the plenum chamber being opposite to the inlet (76) of the plenum chamber (23).