An energy stimulation device having at least one stimulation generator provided with at least one first metal body and at least one the second metal body in contact with the first metal body. The first metal body and the second metal body are different metals. The device also includes at least one stimulation transmitter, the stimulation transmitter having a rigid support separate from the stimulation generator, and the stimulation generator being fixed on the rigid support. The energy stimulation device is applicable to bio-stimulation for therapeutic and non-therapeutic purposes.

A method of altering corneal tissue includes creating an electrochemical reaction in the tissue, wherein the electrochemical reaction occurs in the presence of an electrolytic solution in or on the tissue.

A device for transport of ions and/or charged molecules between a source and a target electrolyte, comprising: a first electrode provided at or in said source electrolyte, and a second electrode provided at or in said target electrolyte; and wherein said first and second electrodes provides an electrical control of an ion flow, and further comprising means for limiting an electronic current between said source and said target electrodes, such that at least after a voltage is applied a potential difference between said source and target electrodes is maintained, which effects ion transport from said source to said target electrode; wherein the device further comprises an ion- and/or permselective polyelectrolyte for transport ions and/or charged molecules via electrophoresis and functions as an ion-selective membrane; and wherein said polyelectrolyte comprises a cross-linked hyperbranched polymer.

A hydrogel ionic circuit (HIC) electrode configured for electrical stimulation and/or drug therapy (e.g., iontophoresis) is disclosed. The HIC electrode includes a chamber containing a salt solution. The chamber is at least partially bound by a hydrogel membrane that defines a barrier for the salt solution. The HIC electrode further includes an electrode configured to apply an electrical current to the chamber to induce an ion current in the salt solution, wherein the hydrogel membrane is ionically conductive and configured to transmit the ion current.

A method, system, and device for electroporation. A system may include a medical device with a plurality of electrodes borne on an expandable element and an energy generator in communication with the electrodes. The energy generator may have processing circuitry configured to selectively deliver electroporation energy to at least one of the electrodes. The processing circuitry may determine whether an alert condition is present and, if so, cease the delivery of electroporation energy to one or more electrodes identified as the cause of the alert condition and/or prevent the delivery of electroporation energy to the one or more electrodes identified as the cause of the alert condition. The energy generator may also be configured to deliver electroporation energy in a sequence of a plurality of energy delivery patterns to enhance lesion formation.

In order to achieve the above or other aims, according to one aspect of the present disclosure, a skin care device is provided which comprises: a body comprising a grip section for a user to hold, and a head section positioned at the end of the grip section; a plurality of skin-contacting plates positioned at the end of the head section; a plurality of oscillators for providing oscillations to each of the skin-contacting plates; and a control unit which supplies an electrical current to the skin-contacting plates and controls the oscillators, wherein the positive electrode and the negative electrode of the control unit are respectively connected to different skin-contacting plates.

A skin treatment device includes a substrate and a plurality of discrete galvanic couples provided on the substrate, each discrete galvanic couple including a first conductive electrode that is an anode and a second conductive electrode that is a cathode, wherein the anode of each galvanic couple includes a first metal and the cathode of each discrete galvanic couple includes a second metal, different from the first metal, the first and second metal having a different standard potential.

The present disclosure relates to a bioelectric hydrogel. In one embodiment, a hydrogel comprises a hydrophilic polymer base and one or more biocompatible electrodes configured to generate at least one of a low level electric field (LLEF) or low level electric current (LLEC). The hydrogel is configured to provide a three-dimensional energy source within the hydrogel or to devises proximate to the hydrogel.

This application is drawn to a method of using an isoform NELL-1 peptide, and compositions thereof for bone formation or for treating, preventing, or ameliorating osteoporosis.

In one embodiment of the present invention, a method and system for the safe use of a tap-water iontophoresis machine is provided. The method is based on the specific treated zone by establishing several different treatment safety parameters according to which treated body zone is selected, such as the hands, feet, or armpits. The system includes a microcontroller, a voltage measuring module, current measuring module, polarity inversion module, and an optional resistance measuring module. The microcontroller adjusts the treatment based on the following: (a) the profile selected; (b) the values embedded in the microcontroller that is associated to the profile selected; and, (c) the values measured by the different modules and the time kept by the microcontroller. By simply choosing the treated zone, the device automatically adjusts these parameters to better reflect the specific particularities of that zone and establish often narrower ranges of values and increase safety and comfort for the patient.