The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

A present idea relates to a device to kill micro-organisms inside the patient's respiratory tract using UV light, specifically UV-C. It is particularly used to treat patients with Coronaviruses family such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The device consists of a triple-lumen catheter and UV control unit. The distal end of one of the catheter's lumen has a curved UV chamber while the proximal end has a cable with a socket to be connected to the UV control unit. The second lumen of the catheter is used for oxygen supply, and the third lumen of the catheter is used for suction.

A process that provides protective therapy for biological tissues or fluids includes applying a pulsed energy source to a target tissue or a target fluid having a chronic progressive disease or a risk of having a chronic progressive disease to therapeutically or prophylactically treat the target tissue or target fluid. The pulsed energy source has energy parameters selected so as to raise the target tissue or bodily target fluid temperature up to a predetermined temperature for a short period of time to achieve a therapeutic or prophylactic effect, while the average temperature rise of the target tissue or target fluid over a longer period of time is maintained at or below a predetermined level so as not to permanently damage the target tissue or target fluid.

A process for preventing or treating myopia includes applying a pulsed energy, such as a pulsed laser beam, to tissue of an eye having myopia or a risk of having myopia. The source of pulsed energy has energy parameters including wavelength or frequency, duty cycle and pulse train duration, which are selected so as to raise an eye tissue temperature up to eleven degrees Celsius to achieve therapeutic or prophylactic effect, such as stimulating heat shock protein activation in the eye tissue. The average temperature rise of the eye tissue over several minutes is maintained at or below a predetermined level so as not to permanently damage the eye tissue.

A treatment method and a treatment system for irradiating the antibody-photosensitive substance bound to the tumor cell membrane in the tumor cell with the near-infrared ray includes: intravenously administering the antibody-photosensitive substance; inserting an endoscope from a mouth, a nose, or an anal and allowing the endoscope to reach a vicinity of a tumor; making a tubular elongated tube, in which a lumen is formed, protrude from the endoscope; bringing the elongated tube into contact with the tumor while checking an image obtained by the endoscope; allowing an optical fiber inserted into the lumen of the elongated tube to reach an inside or the vicinity of the tumor; and irradiating the antibody-photosensitive substance bound to the tumor cell membrane with the near-infrared ray from the optical fiber after 12 hours to 36 hours from the intravenous administration.

A treatment method and a treatment system capable of effectively irradiating an antibody-photosensitive substance bound to a tumor cell with a near-infrared ray. The treatment method for irradiating the antibody-photosensitive substance bound to the tumor cell membrane in the tumor cell with the near-infrared ray includes: intravenously administering the antibody-photosensitive substance; percutaneously puncturing a tumor or a vicinity of the tumor with a hollow outer needle, while percutaneously acquiring and checking an ultrasound image; making an inner needle having a plurality of sharp inner needle tips protrude from the outer needle, and puncturing the tumor or the vicinity of the tumor with the inner needle tips; and irradiating the antibody-photosensitive substance bound to the tumor cell membrane with the near-infrared ray from an optical fiber inserted into the inner needle after 12 hours to 36 hours from the intravenous administration.

Systems and method relate to administering phototherapy. A device includes a hollow structure having at least a first open end. The hollow structure includes a rotatable member, one or more coherent light generators, and, for each coherent light generator, one or more lenses or mirrors optically connected to the coherent light generator and configured to alter at least one aspect of a beam of coherent light. The device further includes a processing circuit including a processor and a memory storing instructions. The instructions, when executed by the processor, cause the processor to accept an input from an operator and generate one or more beams of coherent light according to a plurality of settings configured to produce a therapeutic effect at a targeted treatment site. Additionally, the rotatable member is configured to be rotated to direct the one or more beams of coherent light to the targeted treatment site.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

A system and method can be used to denervate at least a portion of a bronchial tree. An energy emitter of an instrument is percutaneously delivered to a treatment site and outputs energy to damage nerve tissue of the bronchial tree. The denervation procedure can be performed without damaging non-targeted tissue. Minimally invasive methods can be used to open airways to improve lung function in subjects with COPD, asthma, or the like. Different sections of the bronchial tree can be denervated while leaving airways intact to reduce recovery times.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.