A novel photobiomodulation (PBM) system and method that comprehensively directs therapeutic light energy into the brain from a combination of transcranial (through the skull) and intranasal (via the nasal channels) locations. In a preferred embodiment, the PBM device works in combination with a diagnostic tool to provide enhanced treatment of abnormal brain function intelligently, automatically, and unrestricted by geographical distances.

A system that provides neuroprotection or neuroregeneration to biological tissue includes a pulsed energy having energy parameters including a wavelength or frequency, a duty cycle and a pulse train duration. A delivery device applies the pulsed energy to neural elements of the target tissue having a chronic progressive disease or at risk of having a chronic progressive disease. The delivery device applies the pulsed energy for a predetermined total pulse train duration such that the target tissue temperature is raised sufficiently to provide neuroprotection or neuroregeneration to the neural elements of the target tissue, while maintaining the average temperature rise of the target tissue at or below a predetermined level so as not to permanently damage the target tissue.

The present invention provides a nasal disease treatment aid device, comprising: a nose cover which forms a dome so as to cover the nose of a user and covers the nose while being positioned on the nose of the user; a fixing member which is connected to the left and right sides of the nose cover and fixed to the head of the user so that the nose cover is fixed to the nose of the user; insertion members having, interposed therebetween, a support body provided in the inner space of the nose cover and extending outward from the left and right sides of the support body and are formed in tubular shapes each having a hollow inside that communicates back and forth so as to allow the user to breathe through the nostrils; LED light sources which are provided on one side of each of the insertion members and irradiate therapeutic light into the inside of the nose; and low-frequency stimulation units which are provided on each of the left and right sides of the nose cover and physically stimulate paranasal sinuses while in contact with the paranasal sinuses that are around the nose. Therefore, it is possible to provide necessary help for the treatment of rhinitis and paranasal sinusitis at the same time, and infrared treatment light of a corresponding wavelength using the LED light sources and heat treatment by radiation heat from the infrared light are carried out in parallel such that the resulting light and heat is propagated deep into a nasal cavity so as to be able to effectively improve blood circulation, thereby requiring a shorter treatment time and minimizing side effects such as skin rashes and so on caused by prolonged exposure to light and heat.

A diffuser tip assembly is disclosed for generation of uniform cylindrical illumination from a fiber delivered source. Light propagating into the diffuser tip is initially mixed by a spatial overlap of reflections within a waveguide, reducing the sensitivity of illumination uniformity to the modal structure of fiber delivered light. The waveguide output propagates at least two passes through a reflective cavity having transmissive, light-diffusive walls, enabling highly uniform output. The diffuser tip can be configured to use low-absorbing materials for high power applications. In addition, the method of using visible light as an indicator for diffuser output is described. The combination of uniformity, low heat generation, and a visual indicator are intended to promote safety in a phototherapy procedure.

A light-emitting diode (LED) therapy device and method of use is provided that increases healing of tissues by targeting damaged tissue at a predetermined wavelength and pulsed at a predetermined frequency. The device includes a housing and a light radiation module enclosed within the housing. The light radiation module includes an LED, a controller unit connected to the LED to control wavelength and pulsed frequency of the LED, and a rechargeable power source. The device also includes a light-diffusing member connected to the housing designed to diffuse light emitted from the LED to damaged tissue in a human cavity. Light in the red or near infrared range and pulsed at a Nogier frequency increases the effectiveness of the LED device to stimulate healing of damaged tissues. Particular devices include incorporation into a pacifier for healing an infant's gums, or nasal, auditory, vaginal, or anal cavities and adults or children.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

Apparatus and methods are disclosed for treating allergic rhinitis (seasonal and perennial hay fever), by application of flash lamp radiation. The nasal cavity can be illuminated in a safe and effective manner, with non-coherent light from a flash-lamp or other suitable source. This illumination can be accomplished in any suitable manner, including by use of a handheld device. Such handheld embodiments may contain a power source (battery or AC), control circuitry, light source (flash-lamp or diode laser), lens (focusing or non-focusing), light filter, and/or fiber-optic for delivering light to the nasal cavity. Embodiments include using any suitable light energy, such as visible light in the red wavelengths with a power output of 1 to 10 Joules per cm.sup.2. The device can be pre-programmed to deliver a specified amount of light in a specified amount of time using multiple pulses (in the case of a flash lamp) or a continuous wave (in the case of a diode laser). In many useful embodiments, a rigid fiber-optic extends from the lens/light filter a length of 10 to 20 mm, although it can be any convenient and useful size and shape. Contact sensors can be arrayed on the device for various purposes, such as to restrict illumination to times when the fiber optic is inserted into the nasal cavity. This and/or other safety features can prevent the high-intensity light from being fired into open space, a person's eyes, and/or otherwise causing a potential vision or other hazard. Preferably, the device can be easily and comfortably inserted into a nostril. The fiber-optic can be angled (either in its own shape or by the user manipulating it to a convenient angle/position) so as to allow the user to easily grip the device and insert the fiber-optic without having to use a mirror or other aid. Light from the device can be emitted at a specified light frequency that causes a desired immunosuppressive response in the cellular system.

A process that provides protective therapy for biological tissues or fluids includes applying a pulsed energy source to a target tissue or a target fluid having a chronic progressive disease or a risk of having a chronic progressive disease to therapeutically or prophylactically treat the target tissue or target fluid. The pulsed energy source has energy parameters selected so as to raise the target tissue or bodily target fluid temperature up to a predetermined temperature for a short period of time to achieve a therapeutic or prophylactic effect, while the average temperature rise of the target tissue or target fluid over a longer period of time is maintained at or below a predetermined level so as not to permanently damage the target tissue or target fluid.

A system and method of illuminating tissue, particularly within the cranial cavity, through the mouth or nose. The system includes a light source and a power source for powering the light source. Optics are included for directing light from the light source towards the cranial cavity when the apparatus is inserted into a cavity of the head. Light from the light source and output from the optic provides cellular interaction treatment toward a specified area of the head region. Providing illumination where there are already holes in the skull results in more efficient coupling of light to the cells.

A cap for a nasal spray apparatus, the cap including a spray dispensing mechanism and further including a base sealingly mountable on a container of liquid substance to be dispensed; an intermediate section arranged for reciprocating movement relative to the base the intermediate section including the spray dispensing mechanism and having a spray dispensing passage; a cover-section having a depressible flexible portion, coupled to the intermediate-section; and a Light Emitting Diode (LED) connected to a power source through an electric circuit, the LED mounted adjacent the spray dispensing passage so as to be inserted into a nostril therewith; wherein the depressible flexible portion is arranged and configured to cause closure of the electric circuit for activating the LED and to actuate the spray dispensing mechanism, to provide both illumination and spray of liquid substance into the nostril.