Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separating a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space and a cooling tube. In some examples, the UV light source is configured to emit light with wavelengths with a desired intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

System for treatment by photodynamic therapy comprising: —an illuminating device (10) including a light emitting surface for illuminating an internal surface to be treated with a light adapted to activate a photosensitizer compound, the light emitting surface emitting light with a distribution of light power comprising fractions of light power decreasing from a maximum at the light emitting surface, the light emitting surface having a determined illumination profile that provides respective illuminated areas for a plurality of the fractions of light power, —a positioning system (40) adapted to position in real-time the light emitting surface within a reference frame, —an electronic unit (45) connected to the positioning system (40) and adapted to monitor in real-time a dose of light energy delivered to the internal surface based on the illumination profile and the position of the light emitting surface.

An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivering of multiple energies to enhance a visual appearance.

A light-emitting diode (LED) therapy device and method of use is provided that increases healing of tissues by targeting damaged tissue at a predetermined wavelength and pulsed at a predetermined frequency. The device includes a housing and a light radiation module enclosed within the housing. The light radiation module includes an LED, a controller unit connected to the LED to control wavelength and pulsed frequency of the LED, and a rechargeable power source. The device also includes a light-diffusing member connected to the housing designed to diffuse light emitted from the LED to damaged tissue in a human cavity. Light in the red or near infrared range and pulsed at a Nogier frequency increases the effectiveness of the LED device to stimulate healing of damaged tissues. Particular devices include incorporation into a pacifier for healing an infant's gums, or nasal, auditory, vaginal, or anal cavities and adults or children.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivering of multiple energies to enhance a visual appearance.

A laminated laser window having an inner layer transparent to light having wavelengths between 3.5 micrometers and 12 micrometers and having as an outer surface a nanometric-thick outer layer of SiO2. The window allows the passage of light within this wavelength range, for example from a CO2 laser. In The SiO2 outer layer maintains biocompatibility when used in laser devices for insertion into externally accessible bodily cavities.

An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivering of multiple energies to enhance a visual appearance.

The embodiments herein provide an LED based vaginal light therapy device for a plurality of bacterial and fungal infections. The device comprises an LED body, a cervix support, a single or a plurality of LEDs, a switch, a tether, microchip and a battery. One end of the device comprises a cervix support to place the device smoothly against the cervix. A plurality of LEDs is provided over the LED body. The LED body comprises one or more LEDs and each LED emits a light having a wavelength in a therapeutic zone of light. The light emitted are in a range of blue light and/or red light. The microchip is housed within the LED body. The microchip connects a battery to the single or plurality of LED's and is further connected to the switch.