A device is presented for use in treatment of tissues inside a body cavity. The device comprises a probe member having at least a portion thereof carrying a plurality of light sources, at least said portion of the probe member having dimensions and shape suitable for insertion into a certain body cavity and for arranging within the surface thereof a three-dimensional array of said light sources, the light sources being configured and operable to irradiate optical energy outwardly from said probe member.

A treatment method for non-ablative tissue regeneration includes directing at least one laser pulse having a wavelength onto a tissue surface of a human or animal body, and controlling an energy delivery time t.sub.ed of the at least one laser pulse, during which the second half of the pulse energy is delivered, to be sufficiently short, so that, given the wavelength and thus a corresponding penetration depth δ of the at least one laser pulse, a thermal exposure time texp of the tissue surface is smaller than 900 microseconds. The thermal exposure time t.sub.exp of the tissue surface is defined as a time interval in which the temperature of the tissue surface is above T.sub.o + (T.sub.max - T.sub.o)/.sub.2, wherein T.sub.o defines the initial temperature of the tissue surface, before the laser pulse arrives, and T.sub.max is a maximal temperature of the tissue surface.

A device for providing fractional treatment of a body orifice includes a source of fractionated energy and a source of electrical muscle (EMS) energy. A programmed controller controls the application of fractionated and/or EMS energy. A probe is inserted by its distal end into the body orifice. The source of fractionated energy is positioned for transmitting fractionated energy from the source of fractionated energy through the probe to tissue in the vicinity around the body orifice; and, the source of EMS is positioned for transmitting EMS energy from the source of EMS energy through the probe to tissue in the vicinity around the body orifice. The programmed controller is configured to control the activation of fractionated energy and EMS energy one of simultaneously or sequentially.

A treatment method for non-ablative tissue regeneration includes directing at least one laser pulse having a wavelength onto a tissue surface of a human or animal body, and controlling an energy delivery time t.sub.ed of the at least one laser pulse, during which the second half of the pulse energy is delivered, to be sufficiently short, so that, given the wavelength and thus a corresponding penetration depth δ of the at least one laser pulse, a thermal exposure time t.sub.exp of the tissue surface is smaller than 900 microseconds. The thermal exposure time t.sub.exp of the tissue surface is defined as a time interval in which the temperature of the tissue surface is above T.sub.o+(T.sub.max−T.sub.o)/2, wherein T.sub.o defines the initial temperature of the tissue surface, before the laser pulse arrives, and T.sub.max is a maximal temperature of the tissue surface.

A photodynamic therapy apparatus for local targeting in cancer treatment capable of treating various types of cancers or tumors. An endoscope is placed in the center of an end portion of a probe used in photodynamic therapy and a plurality of optical fibers are arranged along the edge thereof, so that a lesion site is irradiated with a plurality of lights while the plurality of optical fibers of the probe receive lights from individual light sources, respectively, to perform light irradiation individually. An apparatus is disclosed, wherein unnecessary damage to normal tissues is minimized by controlling light irradiation regions, for instance, by defining light irradiation regions encompassing a lesion site from an image provided in real time through an endoscope disposed at an end portion of a probe and allowing only individual light sources irradiating the defined light irradiation regions to emit lights to achieve local light irradiation.

An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivering of multiple energies to enhance a visual appearance.

Devices and methods for treating central nervous system disorders by administering light to a user are disclosed. In some embodiments, the devices are positioned away from the user, and in other embodiments, the devices are attached to the user. In some embodiments, the light is applied through the users skin, and in other embodiments, through an implanted or percutaneous device. Representative central nervous system disorders include cognitive, motor, and behavioral disorders. Where these disorders include an inflammatory component, light is administered at wavelengths which decrease inflammation in the brain. Where these disorders are caused by poor vascularization, light is administered at wavelengths which improve vascularization in the brain. The methods also include repairing damage to the blood brain barrier, and can be used to more effectively administer drugs, such as anticancer drugs, to the brain.

The invention described herein provides devices, compositions and methods to treat atrophic vaginitis and other conditions of the vagina using combinations of vaginally applied topical therapies with light emitting devices to relieve symptoms and causations of atrophic vaginitis.

An irradiation device and a treatment method capable of effectively irradiating an antibody-photosensitive substance bound to a cell membrane of cervical cancer with near-infrared light. The treatment method for cervical cancer includes: intravenously administering an antibody-light-absorbing substance; inserting a second irradiation device including a second optical fiber from a vagina into a cervix 12 hours to 36 hours after the intravenous administration; performing irradiation by using the second optical fiber included in the second irradiation device in a direction substantially perpendicular to the second optical fiber; drawing at least a part of a deformation portion included in the second irradiation device to an external uterine ostium and inflating the deformation portion so as to follow a shape of an organ; emitting near-infrared light by using the second optical fiber in a substantially distal direction and/or the direction substantially perpendicular to the second optical fiber; and contracting the deformation portion.

An unattended approach can increase the reproducibility and safety of the treatment as the chance of over/under treating of a certain area is significantly decreased. On the other hand, unattended treatment of uneven or rugged areas can be challenging in terms of maintaining proper distance or contact with the treated tissue, mostly on areas which tend to differ from patient to patient (e.g. facial area). Delivering energy via a system of active elements embedded in a flexible pad adhesively attached to the skin offers a possible solution. The unattended approach may include delivery of multiple energies to enhance a visual appearance.