The present invention is directed to a system and method for photoeradication of microorganisms from a target. The method includes the step of obtaining test data for a plurality of experiments each of which comprises irradiating test microorganisms with a plurality of light pulses having a wavelength that ranges from 380 nm to 500 nm. The light pulses have a plurality of pulse parameters (peak irradiance, pulse duration, and off time between adjacent light pulses) and are provided at a radiant exposure that ranges from 0.5 J/cm.sup.2 to 60 J/cm.sup.2 during each of a plurality of irradiation sessions. The test data comprises a survival rate for the test microorganisms after irradiation with the light pulses. The method also includes the step of analyzing the test data to identify the pulse parameters for the light pulses and the radiant exposure for each of the irradiation sessions that result in a desired survival rate for the test microorganisms. The method further includes the step of irradiating the microorganisms of the target with light pulses having the identified pulse parameters at the identified radiant exposure for each of the irradiation sessions so as to photoeradicate all or a portion of the microorganisms.

A device includes an angiography module, a phototherapy module, a carrier including an optical filter and accommodating the angiography module and the phototherapy module, and a control unit controlling operation of the angiography module and the phototherapy module. The angiography module includes infrared LEDs emitting infrared light through the optical filter to irradiate a limb of a subject, and an infrared sensor sensing a part of the infrared light reflected off the limb to generate a result, based on which the control unit generates an angiogram. The phototherapy module emits infrared light through the optical filter to irradiate the limb for phototherapy.

A pneumatic compression assembly that includes a sleeve having an outer layer and an inner layer that defines a sleeve interior configured to receive a body part of a user, and at least a first vibration assembly configured to provide vibration to the body part of the user. A plurality of inflatable compartments are arranged longitudinally along the sleeve between the inner layer and the outer layer. The first vibration assembly includes a plurality of vibration motors positioned between the inner layer and the outer layer of the sleeve.

A prosthetic liner for use with a prosthetic socket that has a thermoplastic elastomeric (TPE) layer that is in contact with the amputee's residual limb. The TPE layer is not uniform in thickness but has ridges to extend circumferentially around the TPE layer. A fabric exterior layer covers the outer surface of the TPE layer conforming to the ridges and is used as a substrate to form a mechanical bond to an elastomeric material. Impregnating the elastomeric material within the fabric exterior occurs by applying an uncured material to the fabric exterior layer and onto at least the apex surfaces located within the sealing regions thereby creating an air tight boundary layer when inserted into a socket. When a vacuum is applied the air is evacuated from the volume below the seal layer.

A method and device for treating an infection of the nail or nail bed and adjacent tissues through non-thermal means is described. The device illuminates an area with light in the near-infrared region of the electromagnetic spectrum. Preferably, light having wavelengths of from about 870 nm to about 930 nm will be used. Further, the device includes light emitting diodes that are capable of emitting ultraviolet light. These lights are intended to provide a sterile environment for a user using the device.

A wearable ultraviolet light phototherapy device is disclosed. The wearable ultraviolet light phototherapy device can have a substrate or a housing that is to be worn on a body part of a patient. At least one ultraviolet light emitting source located about the substrate or housing can deliver ultraviolet radiation into the body part of the patient. A control module can control operation of the at least one ultraviolet light emitting source. To this extent, the control module can direct the at least one ultraviolet light emitting source to deliver a predetermined amount of ultraviolet radiation at a peak wavelength into the body part of a patient. The control module can determine the predetermined amount of ultraviolet radiation as a function of the patient's susceptibility to ultraviolet radiation.

A wound dressing and method of use is provided that increases healing of tissues by targeting damaged tissue at a predetermined wavelength. The device includes the use of a negative pressure bandage, a flexible light sheet, and one or more bioactive marine extracts. Light emitted from the flexible light sheet penetrates through the bandage to target damaged tissue, which accelerates the wound healing process and works synergistically with the negative pressure bandage and bioactive marine extracts such as collagen fibers, alginate, chitosan and fucoidan, or any combination thereof to accelerate healing.

An osseointegrated fixture of a percutaneous osseointegrated prosthesis (POPs) anchors directly into a bone of a residual limb within an amputation stump. By anchoring directly into the bone, the POPs provides improved mobility, comfort, and function for an amputee, but an interface between an opening in the skin and the osseointegrated fixture, which allows the anchoring directly into the bone, is prone to infection by microbes. An anti-microbial device can be attached to and/or embedded within an extracorporeal portion of the osseointegrated fixture to irradiate at least a portion on the interface with at least one wavelength of light selected for its antimicrobial effects.

Intraoral phototherapy devices receive light from an associated light source and propagate the light into an oral cavity of a patient. The device comprises a light guide that receives light from an external light source. The light guide comprises a main body portion made of an optically transparent soft flexible biocompatible polymeric material sized and shaped to conform to contours of the oral cavity when inserted therein to direct the light to targeted regions of the oral cavity. The main body portion comprises a pair of spaced apart side wings sized and shaped to be received between a patient's teeth and cheeks on opposite sides of the oral cavity and a center flap intermediate the side wings for transmitting and directing the light to targeted regions of the oral cavity. A controller delivers light to the light guide in a controlled manner.

A phototherapy device includes a clothing item. Illuminators are secured to the clothing item and arranged to illuminate at least a portion of a patient wearing the clothing item. The illuminators include light emitting diodes (LEDs) mounted on at least one flexible printed circuit board (PCB). A temperature sensor is secured to the clothing item and positioned to measure a temperature proximate to the patient wearing the clothing item. A control circuit is connected to receive the temperature from the temperature sensor and operative to turn off the illuminators responsive to the temperature exceeding a maximum permitted temperature.