An adjustable illuminator for photodynamically diagnosing or treating a surface includes a plurality of first panels and at least one second panel. The plurality of first panels have wider widths and the at least one second panel has a narrower width. The narrower width is less than the wider widths. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of first panels or the at least one second panel and configured to irradiate the surface with substantially uniform intensity visible light. The plurality of first panels and the at least one second panel are rotatably connected. The at least one second panel is connected on each side to one of the plurality of first panels. The second panel acts as a “lighted hinge” to reduce or eliminate optical dead spaces between adjacent panels when the illuminator is bent into a certain configuration.

An illuminated bassinet including a light source for delivering therapeutic light and anti-bacterial light, where an interlock prevents the anti-bacterial light from being emitted while an infant is located in the bassinet. Also, a surgical illuminator configured to concurrently or alternately emit different wavelengths of light for treating a physiological condition and for affecting perception of the surgical opening.

In alternative embodiments, provided are compositions, including recombinant expression systems and vectors, products of manufacture and kits, and methods, for remotely-controlled and non-invasive manipulation of intracellular nucleic acid expression, genetic processes, function and activity in live cells such as T cells in vivo, for example, activating, adding functions or changing or adding specificities for immune cells, for monitoring physiologic processes, for the correction of pathological processes and for the control of therapeutic outcomes. In alternative embodiments, provided are blue-light-mediated light-inducible nuclear translocation and dimerization (LINTAD) systems for gene regulation to control cell activation based on the integration of light-sensitive LOV2-based nuclear localization, light-induced active transportation via the biLINuS motif, and CRY2-CIB1 dimerization that feature high spatiotemporal control to control or alter cell activities in vivo, for example, to limit CAR T cell activity to the tumor site for immunotherapy applications.

The invention is broadly directed to a skin care apparatus comprising: a camera; a light device for emitting at least one of a blue, a green, a yellow and a red light; a vibration pad; a heating element; a heat sensor; a skin moisture sensor; an iontophoresis module; and a control processor configured to: operate the camera and the skin moisture sensor to perform a skin quality assessment of a user's skin, and operate any one or more of: the light device, the vibration pad, the heating element, the heat sensor, and the iontophoresis module to provide a bespoke skin treatment for the user's skin based on the skin quality assessment.

Photobiomodulation can be used to treat disorders of the gastrointestinal system. The photobiomodulation can be delivered by an intraluminal device (which can be within the gastrointestinal system) that includes at least one light delivery device configured to provide photobiomodulation; at least one photodetector device to measure reflectance based on the photobiomodulation; a processor to receive a reflectance signal from the at least one photodetector device based on the reflectance measured by the at least one photodetector device and process the reflectance signal; and a wireless transceiver coupled to the processor to transmit at least a portion of the processed reflectance signal. The wireless transceiver can communicate with an external device that includes a wireless transceiver to receive the at least the portion of the processed reflectance signal.

A skin care device according to an embodiment of the present disclosure includes a substrate; a case for covering surface of the substrate; and at least one galvanic current application device electrically connected to the substrate, in which each of the at least one galvanic current application device includes a contact head that forms a contact surface with respect to a user's skin and is electrically connected to the substrate; and a holder provided between the substrate or the case and the contact head, and in which the holder includes an elastic fixing body elastically fixing the contact surface of the contact head to a position spaced apart from the case by a predetermined length.

A therapeutic lighting apparatus includes two white light sources each with a different color temperature and a controller. The controller operates the lighting apparatus in either a color temperature fusion mode or a color temperature flickering mode or both simultaneously such that the color temperature flickering mode can be used for treating a patient with Alzheimer's disease. The lighting apparatus can be enhanced with a green light source for supporting a green light mode for treating migraine headache. Similarly, the lighting apparatus can be enhanced with a red light source for supporting a red light mode for tissue repairing. Alternatively, the lighting apparatus can be enhanced with a near-infrared (IR) radiation source for supporting a near-IR mode for lowering the heartbeat, uplifting the mood, and improving the immunization system of a subject.

This disclosure pertains to a system configured to control light exposure for circadian phase management and/or light deficient disorders of a subject. The system comprises a user interface, physiological sensors configured to generate output signals conveying physiological data of the subject, and a light control valve configured to block or reduce blue light ambient radiation reaching eyes of the subject. Processors are in communication with the user interface, the physiological sensors, the light control valve, and radiation generators. The processors cause the system to receive physiological goals of the subject, determine a light control plan based on the physiological goals, the physiological data, environmental data, and time data. The system operates the light control valve to block or reduce blue light ambient radiation based on the light control plan, and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan.

A method of using blue light for inducing angiogenesis for treatment of wounds, burns, and other injuries, or to treat ischemic conditions, is provided. The method comprises irradiating a target with a visible light, wherein the visible light has a dominant emission wavelength ranging from 435 nm to 520 nm, and effective fluence of the visible light ranges from about 0.15 J/cm2 to about 17 J/cm.sup.2.

A facial beautifying and care apparatus includes a beauty bar (1) having an air supply passage (A), a negative pressure connecting hole (132), a conductive suction nozzle (15) and a first connection port (134); an EMS generation module (20) inside the beauty bar (1) electrically connected to the first connection port (134); an external negative pressure unit (6) separated from the beauty bar (1) and having a negative pressure driving control module (62) and a second connection port (637); the negative pressure driving control module (62) having an air supply tube assembly (66) with a negative pressure communicating hole (661); a communicating tube (7) communicating with the negative pressure connecting hole (132) and the negative pressure communicating hole (661); a conductive wire (8) connected to the first connecting port (134) and the second connecting port (637). Accordingly, the effects of facial skin firming, cleaning, beautifying and caring are achieved.