A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.

In one aspect, an example handheld device for providing a spectrochrome output includes (a) an enclosed chamber containing one or more substances; (b) a light source; (c) an electromagnetic coil; (d) one or more magnets; and (e) a housing, wherein the housing is configured to: (i) secure the enclosed chamber; (ii) secure the light source such that an output of the light source is substantially aligned to pass through the enclosed chamber in one or more directions; and (iii) secure the electromagnetic coil around the enclosed chamber such that an electromagnetic field is created in a substantially same direction of the output of the light source through the enclosed chamber.

The present disclosure provides a combined Pulsed Electromagnetic Field (PEMF) therapy and Photobiomodulation (PBM) therapeutic device in the form of a flexible wearable that can be secured to a user's body part to apply targeted radiation to a desired area. The frequencies and pulse patterns of both types of radiation are controlled by a single controller of the device which can switch between a number of pre-set sequences and patterns. The device is wirelessly enabled to allow control via an external user device.

Certain examples involve controlling a circadian impact of a lighting system. For instance, a lighting system includes a first lighting fixture. The first lighting fixture includes at least one lighting element to illuminate a first space and a first controller to control a first light output of the at least one lighting element. Additionally, the lighting system includes a first background circadian system that provides a first modifying factor to the first controller of the first lighting fixture. The first modifying factor is associated with a first circadian impact profile that specifies a first circadian impact level in the first space. Further, the first controller of the first lighting fixture controls the first light output based on the first modifying factor.

A system to manage the sleep and/or the well-being of a passenger/user of an aircraft includes a chair to be installed in a cabin of the aircraft and interaction devices to interact with the user. The system further includes a user terminal configured to receive data relating to characteristics of a user profile of the user, and a control/command module connected to the user terminal, interaction devices and a database storing information relating to characteristics of a flight of the aircraft. The command/control module being configured to pilot the interaction devices according to the data relating to characteristics of the user profile and characteristics of the flight of the aircraft.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Provided herein are methods and systems for modulating temporal patterns of neuronal activity in the brain. A method of the present disclosure may include using optogenetics to stimulate a one or more of thalamocortical projections, thalamic relay neurons, cortical projection neurons, cell bodies in a thalamic submedial nucleus, and cell bodies in the VLO in the brain, in conjunction with fMRI of different regions of the brain to directly visualize the global influence of the VLO's afferent and efferent connections, and characterize how different temporal patterns of activity in the VLO circuit affect brain dynamics by driving its input and output at distinct frequencies.

A light source device, including a first light source, providing a first light beam in a first time period of a first period; and a second light source, providing a second light beam in a second time period of the first period, is provided. The first light beam and the second light beam have the same color temperature. The first light beam and the second light beam are emitted alternately in the first period, and a color rendering index of mixed light of the first light beam and the second light beam is greater than or equal to 85.

The present invention relates generally to a device for providing multi-modal energy therapy to treat neurogenerative disorders, and more particularly to a device providing multi-modal neuro-supportive energy therapy to a person via a daily session in a single facility. The device provides safe, well studied energy therapies in a controlled manner to stimulate neuronal mitochondrial activity which powers the brains neurons and is often defective in neurodegenerative disease states. Selected energy delivery mechanisms and frequencies are employed to stabilize microglial activity and promote microglial homeostasis and neuroprotective secretions, including mitochondrial melatonin and other neuroprotective factors. In addition to practicality, the combination of these proven therapeutic modalities into a single device may offer synergies not found when they are employed alone. This focused combination of these unique energy based therapies may offer new hope to slow, stop, reverse or mitigate neurogenerative disorders, such as Alzheimer's, ALS and Parkinson's diseases.

A device and method for disinfecting and/or enhancing healing of a wound or surgical site facilitates placing a light-emitting device with a frame having a central void, the central void adapted to surround the wound or surgical site; an illumination source disposed on the frame for directing safe, therapeutic light centrally towards the underlying wound or surgical site; and the transparent central void enabling visualization and clinical monitoring of the underlying wound or surgical site.