Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device may comprise a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member and a substrate that supports the tissue penetrating members, wherein the substrate is optionally a flexible substrate.

An optical stimulation system includes a light source configured to produce light for optical stimulation; a light monitor; an optical lead coupled, or coupleable, to the light source and the light monitor; and a control module coupled, or coupleable, to the light source and the light monitor. The control module includes a memory, and a processor coupled to the memory and configured for receiving a request for verification or measurement of a light output value; in response to the request, receiving, from the light monitor, a measurement of light generated by the light source; and, based on the measurement, reporting a response to the request.

Methods and apparatus for dermatological laser treatment, e.g. for the removal of unwanted tattoos or other skin pigmentation. Removal of multiple colors with a single pulsed laser beam may be achieved using intensities in excess of about 50 GB/cm.sup.2. Methods for reducing the pain and tissue damage associated with laser tattoo removal include using a spot size of less than 2 mm with a fluence in the range of 0.5-10 J/cm.sup.2. Scanning the laser beam over an area of skin to be treated allows such areas to be treated accurately with scanning patterns calculated to promote rapid dissipation of heat away from treated portions of the skin. Multiple treatment rooms may be served by a single pulsed treatment laser by beam toggling, splitting or pulse-picking to minimise downtime of the laser.

The present application discloses a LED therapeutic device comprising a top case, a light assembly, a controller, a switch assembly, a bottom case and a power supply. The light assembly comprises a lens and a LED assembly, wherein the lens is coupled to the top case and the LED assembly comprises three visible light LEDs and two infrared LEDs. Wavelengths of the three visible light LEDs are 470 nm, 630 nm and 660 nm. Wavelengths of the two infrared LEDs are 850 nm and 940 nm. The controller is coupled to the light assembly. The switch assembly is coupled to the controller. The bottom case is removably coupled to the top case. The power supply is electrically coupled to the controller.

The device includes a laser source (7) adapted to emit a laser radiation at a wavelength between around 620 nm and around 750 nm, and a handpiece (5). The handpiece in turn includes an applicator (11) with a contact surface with the epidermis defining a window (11.1) for the passage of a laser beam (F) toward the epidermis (E) of a subject to be treated. A waveguide (10) conveys the laser radiation from the laser source (7) to a scanning system (17) of the handpiece.

A method and system for of treating type 1 includes implanting genetically modified islet cells under a capsule of or within an organ, implanting a microsystem adjacent the islet cells, said microsystem, comprising a light emitting diode stimulator comprising a plurality of light emitting diodes, determining a glucose level in a body and controlling the microsystem to selectively illuminate the islet cells to secrete insulin or glucagon or both based on the glucose level.

Dermal neurofibroma, in particular Neurofibromatosis Type I (NF1) leads to progressive tumor proliferation with no known mechanism to inhibit growth. The present invention relates to the use of photodynamic therapy (PDT) for attenuating tumor growth in NF1 patients. More particularly the invention provides a method of treating dermal neurofibroma comprising topically applying a pharmaceutical composition comprising a photosensitizer to the affected area of a patient, incubating the affected area, and irradiating the affected area with a light of suitable wavelength as per the photosensitizer used, wherein the treatment is characterized by inhibiting the progression of tumor growth and/or reduction in tumor size and/or increased mortality rate of the neurofibroma cell.

The invention provides an IPG and lead configuration which boasts both a novel optical folding assembly and an optical processor assembly which offers the advantages of low heat generation and compact package size. The surgical leads provided offer additional advantages over the prior art including integral formation of optical and electrical components in a compact size. The invention further provides processing advantages which measure and compensate for degradation in the optical system over time.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

A kit includes a multi-phase oral composition for whitening teeth and an electromagnetic radiation source. The multi-phase oral composition for whitening teeth includes from about 0.002% to about 30%, by weight of the multi-phase oral composition, of a discontinuous aqueous phase having a bleaching agent, where a concentration of the bleaching agent is up to 10%, by weight of the multi-phase oral composition, and at least about 50%, by weight of the multi-phase oral composition, of a continuous hydrophobic phase of petrolatum. The electromagnetic radiation source is capable of directing electromagnetic radiation with one or more wavelength in the range from about 200 nm to about 1700 nm toward at least one tooth. The electromagnetic radiation source emits electromagnetic radiation in a range from about 100 mW/cm.sup.2 to about 250 mW/cm.sup.2.