Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.

An end effector for a surgical fastening device is provided. The end effector includes a body defining a longitudinal axis, one or more fasteners, an anvil, and a pusher. Each fastener has an unformed configuration and a formed configuration. Each fastener includes first and second arms that extend in opposite directions. The first arm has first and second elbow segments. The first elbow segment is configured to bend as the fastener is formed. The second elbow segment is configured to remain unbent as the fastener is formed. The pusher is configured to advance the fastener distally through the body and into engagement with the anvil to form the fastener against the anvil.

A seed dispensing unit including an applicator handle holder configured to grasp a handle of an elongate applicator, wherein the elongate applicator includes a plurality of radiotherapy seeds at its distal end and a stylet handle grasper configured to grasp a handle of a stylet, wherein the stylet is within the elongate applicator. The seed dispensing unit further includes a casing allowing motion of the applicator handle holder relative to the stylet handle grasper, such that the stylet pushes a seed out of the distal end of the elongate applicator; and a slidable holder configured to couple with the applicator handle and slide relative to the casing.

A method of stapling tissue includes clamping tissue between a cartridge assembly and an anvil assembly of a loading unit, firing the loading unit such that the fasteners secured in the cartridge assembly pass through a body portion of a first buttress that is positioned between the clamped tissue and one of the cartridge assembly or the anvil assembly, trimming a first portion of the first buttress that is adjacent a first edge of the tissue, and removing the first portion of the first buttress from a surgical site. The first buttress capturing fasteners that are fired from a portion of the cartridge assembly which extends beyond the tissue. The first portion of the first buttress including at least one remnant fastener.

A surgical implant is provided comprising a biocompatible member configured for securement to an underlying target surgical site and a radiation source integrated into or onto the biocompatible member. The surgical implant may be one of a clip, pin, or coil and the radiation source includes at least one brachytherapy capsule, or other radioactive material incorporated therein or provided thereon. The radioactive material provides a dose of radiation to the target surgical site. The surgical implant may also be formed from titanium, stainless steel or polymers. A surgical applier is provided for allowing a surgeon to apply the implant to a patient's tissue.

A device for implanting radiotherapy seeds in a tumor. The device includes a delivery tube having a distal end designed to enter the tumor, and defining an internal channel and an elongate applicator carrying one or more radiotherapy seeds each having a length of at least 1 millimeter, the applicator passing through the internal channel of the delivery tube. When a distal end of the elongate applicator is near a distal end of the delivery tube, it assumes an angle relative to an axis of the delivery tube, such that seeds ejected from the elongate applicator enter the tumor at an angle relative to the axis of the delivery tube.

A system for loading a surgical buttress with a radioactive material includes a surgical buttress, a radioactive material delivery instrument, and a radioactive material. The surgical buttress includes a body portion defining a first width when in a pre-loaded configuration and a second width when in a loaded configuration. The radioactive material delivery instrument includes an elongate body extending from a handle assembly. The elongate body defines a lumen therethrough and has an open distal end. The radioactive material is disposed within the lumen of the elongate body of the radioactive material delivery instrument.

A casing holding one or more brachytherapy seeds for implanting in a patient, which in turn carry atoms of a radioactive element for radiotherapy treatment is filled with a viscous liquid in a manner preventing radiation from the one or more brachytherapy seeds from exiting the casing. The casing may include a metallic or non-metallic elongated tube configured for insertion into tissue or a vial for delivering a seed to a physician for insertion into a needle.

The present invention discloses a radioactive source delivery system and its method of use. The radioactive source delivery system comprise a radioactive source delivery mechanism connecting to the needle trocar via a flexible delivery tube, through which the radioactive source is implanted into a target body; and a needle pulling driver driving the flexible delivery tube which connects to the needle trocar inserted into the target body and controls the needle trocar to be pulled partly out of the target body, thereby adjusting the implantation position of the radioactive source.

Devices and techniques for permanent application of radioactive sources in the field of brachytherapy are described. In an embodiment, an implantable device for radiation therapy of pathological tissues directed toward the administration of radiation to tissue adjacent a cavity wall or surgical excision. The device may include an insertable member, such as a substantially cylindrical member, having at least two ends, a central section positioned between the ends, and a fixation element to retain the implantable device implanted in tissue at a desired position. The device may further include a radioactive source at least partially positioned within the insertable member and that is disposed to deliver radiation to a desired area.