Methods and devices for minimally-invasive delivery of radiation to the eye (such as the posterior portion of the eye) including cannula systems with multiple treatment positions and/or multiple channels in the distal tip of the cannula systems. The channels can accommodate emanating sources and exposing a target at various treatment positions. The emanating sources may be annulus-shaped.

A method for treating, preventing and/or reducing neurodegeneration in subjects with neurodegenerative disease, such as those neurodegenerative diseases that affect the eye, including glaucoma, using radiation, such as gamma radiation or X-ray radiation, either alone or together with a bone marrow transfer treatment. The method includes irradiating a targeted area of an animal, such as the eye region, with radiation, either alone or followed by injection with T-cell depleted bone marrow cells. Also a method for screening and/or selecting agents and/or treatment methods for inhibiting, treating and/or reducing neurodegeneration, particularly the neurodegeneration of the eye that occurs as a consequence of glaucoma.

Provided herein is technology relating to analysis of images and particularly, but not exclusively, to methods and systems for determining the area and/or volume of a region of interest using optical coherence tomography data. Some embodiments provide for determining the area and/or volume of a lesion in retinal tissue using three-dimensional optical coherence tomography data and a two-dimensional optical coherence tomography fundus image.

A radiotherapy device includes an electron source, a first beam corrector, a drift tube, a target with target material that when impacted by an electron beam generates Bremsstrahlung x-ray photons, and a radiosurgical needle. The radiosurgical needle has an elongated radiopaque needle body with a lumen and a pointed tip for piercing a tissue of a patient. The target is positioned within the lumen of the radiosurgical needle. A first beam steering device steers a focused electron beam within the micro drift tube to the target. A radiotherapy system and a method for conducting radiotherapy are also disclosed.

A control circuit automatically models a multi-field treatment arrangement as a single composite trajectory that includes a plurality of treatment fields to provide a single composite/multi-field treatment arrangement, and then optimizes the multi-field radiation treatment plan as a function of the single composite/multi-field treatment arrangement.

Provided herein is a neoadjuvant therapy and/or adjuvant therapy for the treatment of uveal melanoma, inter alia, ocular tumors in uveal melanoma to reduce the incidence of metastasis and/or enucleation and/or preserving eye function.