The disclosure pertains to improvements in a gamma radiation source, typically containing low-density alloys or compounds or composites of iridium in mechanically deformable and compressible configurations, within a sealed encapsulation, and methods of manufacture thereof.

Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.

A radiation system may include a treatment assembly including a first radiation source, a second radiation source, and a first radiation detector. The first radiation source may be configured to deliver a treatment beam covering a treatment region of the radiation system, and the treatment region may be located in a bore of the radiation system. The second radiation source may be configured to deliver a first imaging beam covering a first imaging region of the radiation system, and may be mounted rotatably on a first side of the treatment assembly. The first radiation detector may be configured to detect at least a portion of the first imaging beam, and may be mounted rotatably on a second side of the treatment assembly. The treatment assembly, the second radiation source, and the first radiation detector may be positioned such that the treatment region is addressable for the radiation system.

A radiation source that simultaneously produces two radiation frequencies of combined radiation, in order to break apart a mutated DNA base pair. The radiation source produces combined radiation, the combined radiation being for a thymine base and a cytosine base in a thymine and cytosine base pair. The radiation source produces combined radiation, the combined radiation being for a guanine base and a thymine base in a guanine and thymine base pair. The radiation source produces combined radiation, the combined radiation being for an adonine base and a guanine base in an adonine and guanine base pair. The radiation source produces combined radiation, the combined radiation being for an adonine base and a cytosine base in an adonine and cytosine base pair.

A balloon applicator for an intraoperative radiation therapy system includes an x-ray beam shaping component for emitting x-rays in a plurality of possible directions in three dimensions. The balloon applicator includes connecting structure for connecting to the intraoperative radiation therapy system and an inflatable balloon contactor having an outer surface. The balloon applicator has a beam hardening system including a beam hardening compound disposed between the x-ray beam shaping component and the outer surface of the balloon. The beam hardening system is capable of hardening the beam in beam directions in three dimensions. An intraoperative radiation therapy system and a method for conducting intraoperative radiation therapy are also disclosed.

A radiation source that simultaneously produces two radiation frequencies of combined radiation, in order to break apart a mutated DNA base pair. The radiation source produces combined radiation, the combined radiation being for a thymine base and a cytosine base in a thymine and cytosine base pair. The radiation source produces combined radiation, the combined radiation being for a guanine base and a thymine base in a guanine and thymine base pair. The radiation source produces combined radiation, the combined radiation being for an adonine base and a guanine base in an adonine and guanine base pair. The radiation source produces combined radiation, the combined radiation being for an adonine base and a cytosine base in an adonine and cytosine base pair.

A medical device includes: a base; a positioner coupled to the base; an accelerator coupled to the positioner, wherein the positioner is operable to rotate the accelerator relative to the base about at least two axes; and a power source coupled to the accelerator, the power source configured to provide microwave power for the accelerator, wherein a position of the power source relative to the base remains fixed during movement of the accelerator. A medical device includes: a base; a positioner coupled to the base; an accelerator coupled to the positioner; a power source configured to provide microwave power for the accelerator, wherein a position of the source relative to the base remains fixed during movement of the accelerator; and a waveguide for coupling the power source and the accelerator; wherein the waveguide has a first segment with a first cross section, the first cross section being a circular cross-section.

The disclosure pertains to improvements in a gamma radiation source, typically containing low-density alloys or compounds or composites of iridium in mechanically deformable and compressible configurations, within a sealed encapsulation, and methods of manufacture thereof.

The present disclosure discloses a boron neutron capture therapy system comprising: a boron neutron capture therapy device and an -amino acid-like boron trifluoride compound having a structure shown as formula (I) below:

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Wherein: R is selected from hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, hydroxymethyl, 1-hydroxyethyl, benzyl or hydroxybenzyl; M is H or metal atom. The energy generated from the action of the neutron beam generated by the boron neutron capture therapy device on the -amino acid-like boron trifluoride compound destroys tumor cell DNA. In another aspect, the present disclosure discloses a use of an -amino acid-like boron trifluoride compound in the preparation of a medicament for tumor therapy.

A system for selecting a calibration includes a data structure (138) including non-transitory computer readable storage media having a plurality of calibration entries stored therein and indexed to position and/or orientation criteria for a field generator. The field generator is configured for placement in an environment for sensor tracking. A calibration selection module (140) is configured to determine a position and/or orientation of the field generator and, based on the position and/or orientation, determine, using the data structure, corresponding calibration information stored in the data structure. The calibration information is optimized based upon the position and/or orientation of the field generator.