Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer includes pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

This invention relates to MEMS X-ray sources based on carbon nanotube coated with metal oxides and metal oxide crystals and insulated with parylene for parallel microbeam intraoperative 100 to 1,000 Gy radiation therapies with minimal toxicity to normal tissue. It sterilizes cancer stem cells that cause tumor recurrence and metastasis. It generates high brightness, 10,000 to 20,000 Gy/s radiations that is closer to synchrotron radiation's dose rate. The parallel microbeam generating X-ray sources are microfabricated with CNT and its variant herringbone, stacked carbon nanotube. They are implantable or contact therapy X-ray sources. Each microfocus carbon nanotube based X-ray source is capable of switching a series of parallel microbeam simultaneously or in sequence. The 100-1,000 Gy single fraction radiosurgery exposes tumor antigens that induce local and systemic tumor immunity. It avoids adaptive resistance to radiation therapy as with 2 Gy daily fractionated radiation therapies that lasts several weeks.

The present invention relates in particular to methods and apparatuses for generating and/or providing X-ray radiation with specific radiation characteristics, in particular with a specific radiation dose rate curve (10). In order to provide simple and cost efficient solution, it is provided according to the invention, that the X-ray radiation is generated and/or provided, by composing and/or adapting the X-ray radiation with the specific radiation characteristics, in particular with the specific radiation dose rate curve (10), proportionally from a first specification X-ray radiation with a defined first radiation characteristics, in particular with a predetermined first radiation dose rate curve (11) and a second specification X-ray radiation, which is different from the first specification X-ray radiation, with defined second radiation characteristics, in particular with a predetermined second radiation dose rate curve (12).

A radiotherapy device includes an electron source, a first beam corrector, a drift tube, a target with target material that when impacted by an electron beam generates Bremsstrahlung x-ray photons, and a radiosurgical needle. The radiosurgical needle has an elongated radiopaque needle body with a lumen and a pointed tip for piercing a tissue of a patient. The target is positioned within the lumen of the radiosurgical needle. A first beam steering device steers a focused electron beam within the micro drift tube to the target. A radiotherapy system and a method for conducting radiotherapy are also disclosed.

A radiotherapy system has at least one radiation source with a particle accelerator and a control unit for configuring the at least one radiation source. The system is configured in a first configuration to irradiate one or more sub-volumes and/or adjacent volumes of a target using at least one monoenergetic proton ultra-high dose rate beam and a second configuration to irradiate a remaining volume of the target using a non-ultra-high dose rate beam, wherein the radiation is delivered using a range of energies. A computer-implemented method of operating a radiotherapy system is also disclosed.

A fluid injector system includes at least one fluid reservoir having a first fluid reservoir configured for injecting a radiopharmaceutical and a radiation filter in fluid communication with the at least one fluid reservoir. The radiation filter is configured for retaining radioactive particles from the radiopharmaceutical passing though the radiation filter. The system further includes at least one sensor configured to detect radioactivity in at least one of the first fluid reservoir, the radiation filter, and a fluid path element in fluid communication with the radiation filter; and a controller in operative communication with the at least one sensor. The controller is programmed or configured to receive a radioactivity measurement from the at least one sensor and determine, based on the radioactivity measurement, that an amount of radioactive particles in at least one of the first fluid reservoir, the radiation filter, and the fluid path set satisfies a predetermined threshold.

A neutron capture therapy system. The neutron capture therapy system includes: a charged particle generation device used for generating charged particles; an accelerator used for accelerating the charged particles; a neutron generation device including a particle transmission part and a neutron generation part provided in a first end part of the particle transmission part, wherein the charged particles can pass through the particle transmission part and interact with the neutron generation part to generate neutrons; a beam shaping body having an accommodating cavity, wherein the accommodating cavity includes a first surface and a second surface intersecting with the first surface, and the first end part is provided in the accommodating cavity; and a first fitting part provided between the first surface of the accommodating cavity and the outer surface of the particle transmission part. The first fitting part is configured to at least surround part of the particle transmission part.

A fluid injector system includes at least one fluid reservoir having a first fluid reservoir configured for injecting a radiopharmaceutical and a radiation filter in fluid communication with the at least one fluid reservoir. The radiation filter is configured for retaining radioactive particles from the radiopharmaceutical passing though the radiation filter. The system further includes at least one sensor configured to detect radioactivity in at least one of the first fluid reservoir, the radiation filter, and a fluid path element in fluid communication with the radiation filter; and a controller in operative communication with the at least one sensor. The controller is programmed or configured to receive a radioactivity measurement from the at least one sensor and determine, based on the radioactivity measurement, that an amount of radioactive particles in at least one of the first fluid reservoir, the radiation filter, and the fluid path set satisfies a predetermined threshold.

A fluid injector system includes at least one fluid reservoir having a first fluid reservoir configured for injecting a radiopharmaceutical and a radiation filter in fluid communication with the at least one fluid reservoir. The radiation filter is configured for retaining radioactive particles from the radiopharmaceutical passing though the radiation filter. The system further includes at least one sensor configured to detect radioactivity in at least one of the first fluid reservoir, the radiation filter, and a fluid path element in fluid communication with the radiation filter; and a controller in operative communication with the at least one sensor. The controller is programmed or configured to receive a radioactivity measurement from the at least one sensor and determine, based on the radioactivity measurement, that an amount of radioactive particles in at least one of the first fluid reservoir, the radiation filter, and the fluid path set satisfies a predetermined threshold.

Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.