The disclosure pertains to a strontium-90 sealed radiological or radioactive source, such as may be used with treatment of the eye or other medical or industrial processes. The sealed radiological source includes a radiological insert within an encapsulation. The encapsulation may include increased shielding in the center thereof.

Aspects herein are directed to an anchorable brachytherapy device configured to be permanently implanted in a tumor bed at the time of operative removal of the tumor. In exemplary aspects, the brachytherapy device may comprise a plurality of hollow tubes that form a spherical or ellipsoid shape. Protrusions or grooves may be formed on an outer surface of the tubes to help anchor the brachytherapy device in the tumor bed. Radioactive seeds or strands may be positioned within the tube channels to provide radiation to the tumor bed.

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.

Systems and devices for applying radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g., to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The systems and devices of the present invention provide for the application of beta radiation to the target area, wherein the beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that may occur after insertion of an implant into the eye or introduction of a hole for the purpose of draining aqueous humor to maintain a healthy intraocular pressure. By reducing inflammation and/or fibrogenesis, the implant, the hole, the blebs, or other related structures or tissues can remain functioning appropriately.

A carrier having one or more non-planar surfaces may be embedded with one or more radioactive seeds. A spherical carrier may be substantially radially symmetrical around an axis or a spherical carrier may include a non-spherical portion, such as a tapered portion that extends from a spherical portion.

Custom radioactive seed carriers are fabricated pre-operatively and/or intra-operatively to more precisely match carrier specification of a radiation treatment plan for a particular patient. One or more carrier specification component, such as a 3D printer, injection molding system, machining component, or bioprinter, may be utilized to create the custom carrier.

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.

Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.

[Summary] [Problem] The therapy method and the therapy apparatus for difficult cancer such as ductal cancer and other diseases. [Solution to problem] The therapy and the apparatus to beat cancer and other diseases by injecting the material which is energy receptive from outside and emissive heat to cancer cells in the body of a patient, and giving energy from outside.

A device for loading brachytherapy seeds and spacers into a sleeve. The device holds two or more seed or spacer cartridges of different radioactive species and dosage. The user rotates a selector for selecting a desired cartridge and, with each depression of a spring-biased plunger, pushes a seed or spacer into a channel in an inspection area. The process is repeated for the desired number and order of seeds and spacers in sequence to form a strand. The strand can be seen in the channel with the unaided eye through a transparent window. Once the strand is arranged as desired, it is pushed into a sleeve that is held in a removable sleeve holder. If desired, the end portions of the filled sleeve may be cut off using a sleeve cutter to shorten the filled sleeve. The filled sleeve is implanted into patient using a needle.