Apparatus and techniques are described herein for nuclear magnetic resonance (MR) projection imaging. Such projection imaging may be used to control radiation therapy delivery to a subject, such as including receiving reference imaging information, generating a two-dimensional (2D) projection image using imaging information obtained via nuclear magnetic resonance (MR) imaging, the 2D projection image corresponding to a specified projection direction, the specified projection direction including a path traversing at least a portion of an imaging subject, determining a change between the generated 2D projection image and the reference imaging information, and controlling delivery of the radiation therapy at least in part using the determined change between the obtained 2D projection image and the reference imaging information.

Removable marker implants having fiducial markers disposed on multiple elongate members extend and splay laterally outward when deployed thereby providing improved 3D localization and tracking of a portion of the patient's body for stereotactic radiosurgery. Such an approach is particularly useful for tracking of the uterus during radiosurgery treatment of uterine fibroids. Such implants can include an outer sheath that contains the multiple elongate members during delivery into the portion of the body. The elongate members can be slidably disposed within the shaft and advanced into an expanded deployed position by advancement of an applicator shaft or rod within the sheath. Marker implant can also be integrally formed implants with flexible arms having fiducial markers thereon that can be constrained in a sheath for delivery and resiliently splay laterally outward when released from the shaft. Methods of delivery and deployment are also provided.

A method may include obtaining a first acquisition time period related to a scan of a first modality performed on an object. The method may also include obtaining one or more second acquisition time periods related to a scan of a second modality performed on the object. The method may also include obtaining, based on the first acquisition time period and the one or more second acquisition time periods, target data of the object acquired in the scan of the first modality. The method may also include generating one or more target images of the object based on the target data.

During a focused-ultrasound or other non-invasive treatment procedure, the motion of the treatment target or other object(s) of interest can be tracked in real time based on (i) the comparison of treatment images against a reference library of images that have been acquired prior to treatment for the anticipated range of motion and have been processed to identify the location of the target or other object(s) therein and (ii) complementary information associated with the stage of the target motion during treatment.

Systems and methods are disclosed for monitoring anatomic position of a human subject and modifying a radiotherapy treatment based on anatomic position changes, as determined with a regression model trained to estimate movement of a region of interest. Example operations for movement monitoring and therapy control include: obtaining 3D image data for a subject, which provides a reference volume and at least one defined region of interest; obtaining real-time 2D image data corresponding to the subject, captured during the radiotherapy treatment session; extracting features from the 2D image data; producing a relative motion estimation of a region of interest with a machine learning regression model, the model trained to estimate a spatial transformation from the 2D image data based on training from the reference volume; and controlling a radiotherapy beam of a radiotherapy machine used in the radiotherapy session, based on the relative motion estimation.

A radiation delivery system that includes a gantry to extend along one or more axes. The gantry is to provide a continuous rotation. The radiation delivery system includes a linear accelerator (LINAC) coupled to the gantry. The LINAC is to generate a treatment beam. The radiation delivery system includes a rotary joint coupled to the gantry. The rotary joint provides a physical connection from the LINAC to an external system that is positioned off the gantry. The physical connection is to transport radio frequency (RF) power.

A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.

The present disclosure provides a method for imaging of moving subjects. The method may include determining a motion range of a region of interest (ROI) of a subject in an axial direction. The method may also include causing a radiation source to emit, at each of a plurality of axial positions relative to the subject, radiation beams to the ROI to generate an image frame of the ROI. The radiation beams corresponding to the plurality of axial positions may jointly cover the motion range of the ROI in the axial direction. The method may further include determining a position of the ROI in the axial direction based on the image frames of the ROI, and determining, based on the positions of the ROI in the axial directions, at least one time bin in which therapeutic beams are to be emitted to the ROI.

Systems and methods are disclosed for detecting Cherenkov radiation produced during radiotherapy. A radiotherapy system comprises a patient receiving space for receiving a patient, a therapeutic radiation source, and a light detector configured to detect Cherenkov radiation subsequent to the emission of therapeutic radiation. Optionally, the system may make use of a optically transmissive dielectric to produce Cherenkov radiation.

Systems and methods are provided for radiation delivery. An exemplary method includes receiving an image depicting anatomical data of a target region of patient tissue and determining an initial prescribed dose of radiotherapeutic radiation to be delivered to the target region. The method also includes discretizing the arc for VMAT into a plurality of arc segments and performing an iteration process for determining an arc dose according to radiation delivered in the arc segments. The method further includes determining whether a condition for terminating the iteration process is met and terminating the iteration process based on a result of the determination that the condition for terminating the iteration process is met.