A computer-implemented method of performing a radiation therapy process includes: while a patient is disposed in a first position and maintains a first inspiration level, acquiring a set of projection images of a target volume associated with the patient; based on a treatment planning digital volume associated with the radiation therapy process and the set of projection images, generating a synthetic digital volume that includes the target volume; based on a treatment plan associated with the treatment planning digital volume and on the synthetic digital volume, generating a modified treatment fraction; and while the patient remains in the first position and maintains at least the first inspiration level, performing the modified treatment fraction.

Systems and methods are disclosed for monitoring anatomic position of a human subject for a radiotherapy treatment session, based on use of a regression model trained to estimate movement of a region of interest based on 2D image data input. Example operations for movement estimation include: obtaining 3D image data for a subject, which provides a reference volume and at least one defined region of interest; obtaining 2D image data corresponding to the subject, captured in real time (during the radiotherapy treatment session); extracting features from the 2D image data; analyzing the extracted features with a machine learning regression model, trained to estimate a spatial transformation in the three dimensions of the reference volume; and outputting and using a relative motion estimation of the at least one region of interest, produced from the machine learning regression model, the relative motion estimation being estimated from the extracted features.

A sterilizable device comprising electromagnetic transponders separated from one another by a flexible spacer material enclosed within radiofrequency-transparent sterilizable tubing for target tracking during prostate treatments, and method of use thereof.

A radiation medical device, including a main support, and a radiation assembly (30) and an imaging assembly (20) respectively located at both ends of the main support. After an imaging scan is completed and pathological tissue positioning pictures are taken, a patient is directly moved to the other end of the main support to allow the radiation assembly (30) to perform radiation therapy to improve the efficiency of the radiation therapy after the completion of pathological tissue positioning, and effectively reduce movement of the patient when the patient is being moved for radiation therapy after the imaging assembly (20) completes pathological tissue positioning, thus reducing pathological tissue positioning error caused by too much movement.

A radiation system is provided. The radiation system may include a bore accommodating an object, a rotary ring, a first radiation source and a second radiation source mounted on the rotary ring and a processor. The first radiation source may be configured to emit a first cone beam toward a first region of the object. The second radiation source may be configured to emit a second beam toward a second region of the object, the second region including at least a part of the first region. The processor may be configured to obtain a treatment plan of the object, the treatment plan including parameters associated with radiation segments. The processor may be further configured to control an emission of the first cone beam and/or the second beam based on the parameters associated with the radiation segments to perform a treatment and a 3-D imaging simultaneously.

A radiotherapy apparatus for the delivery of an energetic beam to a target tissue in a treatment zone, including: a rotatable gantry for rotating the end of a beam delivery system about a circle centered on an isocentre and normal to an axis of rotation Z1 of the gantry, the path between the end of the beam delivery system and the isocentre defining a central beam axis Z2 at every rotation angle of the gantry about the axis of rotation Z1; an imaging ring having a central bore and an imaging system for acquiring images of a patient in an imaging zone of the imaging system, wherein the imaging ring is located in the radiotherapy apparatus such that its imaging zone intersects the axis of rotation Z1 of the gantry, and wherein the imaging ring is mechanically coupled to the rotatable gantry through a mechanical structure.

A computer-implemented method for calibrating a multi-leaf collimator of a radiotherapy device. The multi-leaf collimator comprises a plurality of leaves, each leaf comprising an imaging marker, wherein the radiotherapy device includes an imaging device configured to image the leaves. The method comprises: receiving, from the imaging device, an image of the multi-leaf collimator in a calibration position, wherein in the calibration position the tips of the leaves abut an edge of a rigid calibration block, the edge having a known calibration profile; calculating for each leaf, from the calibration profile and the location of the marker in the image, a minor offset of the marker relative to a reference point; and outputting calibration values based on the calculated minor offsets, wherein at least one leaf of the multi-leaf collimator is controlled based on the calibration values.

A multi-axis imaging system comprising an imaging gantry with an imaging axis extending through a bore of the imaging gantry, a support column that supports the imaging gantry on one side of the gantry in a cantilevered manner, and a base that supports the imaging gantry and the support column. The imaging system including a first drive mechanism that translates the gantry in a vertical direction relative to the support column and the base, a second drive mechanism that rotates the gantry with respect to the support column between a first orientation where the imaging axis of the imaging gantry extends in a vertical direction parallel to the support column and a second orientation where the imaging axis of the gantry extends in a horizontal direction parallel with the base, and a third drive mechanism that translates the support column and the gantry in a horizontal direction along the base.

Systems and methods relate to multi-modal imaging of tissue combined with highly focused radiation interventions. The system is a portable multimodal imaging unit that integrates imaging and image analysis. The system can be retrofitted to use with any commercial radiation therapy machine. In one aspect, a system integrates various imaging modalities into a single, coordinated structure. The system integrates X-ray and cone beam computed tomography (CBCT), optical imaging (such as bioluminescent imaging (BLI), fluorescence tomography (FT)), and positron emission tomography (PET) imaging in a single, self-contained structure.

An imager includes: an array of imager elements configured to generate image signals based on radiation received by the imager; and circuit configured to perform readout of image signals, wherein the circuit is configured to be radiation hard. An imager includes: an array of imager elements configured to generate image signals based on the radiation received by the imager; and readout and control circuit coupled to the array of imager elements, wherein the readout and control circuit is configured to perform signal readout in synchronization with an operation of a treatment beam source.